Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
NaturePublished 1 February 1990
Tatsuhiko Kodama, Mason W. Freeman, Lucia Rohrer, James R. Zabrecky, Paul Matsudaira, Monty Krieger
Citations1,044
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The trimeric structure of the bovine type I scavenger receptor contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk.
Abstract
The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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