Katalyse mit primären Cinchona‐Aminen zur asymmetrischen Funktionalisierung von Carbonylverbindungen
Angewandte ChemiePublished 15 August 2012
Paolo Melchiorre
Citations119
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Abstract
Abstract Die asymmetrische Aminokatalyse verwendet chirale primäre und sekundäre Amine, um asymmetrische Reaktionen zu katalysieren. Methoden dieser Art haben die Funktionalisierung von Carbonylverbindungen stark vereinfacht und bieten zudem hohe Enantioselektivitäten. Jüngste Fortschritte in der Katalyse mit primären Cinchona‐Aminen haben neue Synthesemöglichkeiten und konzeptionelle Perspektiven aufgezeigt, um die großen Herausforderungen in der Carbonylchemie, die mit bisherigen Ansätzen nicht gelöst werden konnten, anzugehen. Dieser Aufsatz fasst die wichtigsten Meilensteine bei der Entwicklung dieser Katalysatorklasse im historischen Kontext zusammen.
Keywords
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