Unveiling the longitudinal association between short sleep duration and the incidence of obesity: the Penn State Cohort
International Journal of ObesityPublished 12 September 2013Open access
Alexandros N. Vgontzas, Julio Fernández‐Mendoza, T Miksiewicz, Ilia Kritikou, Michele L. Shaffer, Duanping Liao
Citations133
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Self-reported short sleep duration in non-obese individuals at risk of developing obesity is a surrogate marker of emotional stress and subjective sleep disturbances, and is not associated with a significant increased risk of incident obesity.
Abstract
Self-reported short sleep duration in non-obese individuals at risk of developing obesity is a surrogate marker of emotional stress and subjective sleep disturbances. Objective short sleep duration is not associated with a significant increased risk of incident obesity. The detection and treatment of sleep disturbances and emotional stress should become a target of our preventive strategies against obesity.
Keywords
PsychologyMedicine
PubMedPrevalence of obesity in the United States, 2009-2010.
1,991 Citations2012Cynthia L. Ogden, Margaret D. Carroll +2 more
There has been a significant increase in obesity prevalence among men and boys but not among women and girls overall over the last decade, and among children and adolescents, the prevalence of obesity was higher among adolescents than among preschool-aged children.
American Journal of Respiratory and Critical Care MedicinePrevalence of Sleep-disordered Breathing in Women
1,590 Citations2001Edward O. Bixler, Alexandros N. Vgontzas +5 more
The data combined indicate that menopause is a significant risk factor for sleep apnea in women and that hormone replacement appears to be associated with reduced risk.
Journal of the American Statistical AssociationSampling Methods for Random Digit Dialing
1,376 Citations1978Joseph Waksberg
A method of sample selection for household telephone interviewing via random digit dialing is developed which significantly reduces the cost of such surveys as compared to dialing numbers completely at random.
Proceedings of the National Academy of SciencesChronic stress and obesity: A new view of “comfort food”
1,372 Citations2003Mary F. Dallman, Norman C. Pecoraro +8 more
It is proposed that people eat comfort food in an attempt to reduce the activity in the chronic stress-response network with its attendant anxiety, which may explain some of the epidemic of obesity occurring in the authors' society.
Molecular PsychiatryOrganization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
1,258 Citations2002P W Gold, George P. Chrousos
The mediators and circuitries of the stress system are reviewed to lay the groundwork for placing in context physiologic and structural alterations in depression that may occur as part of stress system dysfunction.
American Journal of Respiratory and Critical Care MedicineEffects of Age on Sleep Apnea in Men: I. Prevalence and Severity
1,235 Citations1998Edward O. Bixler, Alexandros N. Vgontzas +3 more
The study shows that the prevalence of sleep apnea tends to increase with age but that the clinical significance (severity) of apnea decreases, and that the sleep laboratory criteria used for diagnosis ofSleep apnea should be adjusted for age.
Sleep MedicineEpidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors
1,152 Citations2006Charles M. Morin, Mélanie LeBlanc +3 more
These findings confirm the high prevalence of insomnia in the general population, while few insomnia sufferers seek professional consultations, many individuals initiate self-help treatments, particularly when daytime impairments such as fatigue become more noticeable.
Sleep Medicine ReviewsHyperarousal and insomnia: State of the science
900 Citations2009Michael H. Bonnet, Donna L. Arand
An animal model that has used odor stress to produce poor sleep in rats has identified specific activated brain sites similar to those found in human brain metabolic studies to suggest that insomnia is a state in which sleep and arousal systems are both simultaneously active.
The Journal of Clinical Endocrinology & MetabolismChronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications
837 Citations2001Alexandros N. Vgontzas, Edward O. Bixler +6 more
It is concluded that insomnia is associated with an overall increase of ACTH and cortisol secretion, which, however, retains a normal circadian pattern, consistent with a disorder of central nervous system hyperarousal rather than one of sleep loss, which is usually associated with no change or decrease in cortisol secretion or a circadian disturbance.
Sleep Medicine ReviewsInsomnia with objective short sleep duration: The most biologically severe phenotype of the disorder
767 Citations2013Alexandros N. Vgontzas, Julio Fernández‐Mendoza +2 more
Evidence is presented that insomnia with objective short sleep duration is the most biologically severe phenotype of the disorder, as it is associated with cognitive-emotional and cortical arousal, activation of both limbs of the stress system, and a higher risk for hypertension, impaired heart rate variability, diabetes, neurocognitive impairment, and mortality.
The Journal of Clinical Endocrinology & MetabolismExcessive Daytime Sleepiness in a General Population Sample: The Role of Sleep Apnea, Age, Obesity, Diabetes, and Depression
715 Citations2005Edward O. Bixler, Alexandros N. Vgontzas +4 more
It appears that the presence of EDS is more strongly associated with depression and metabolic factors than with sleep-disordered breathing or sleep disruption per se, and patients with a complaint of E DS should be thoroughly assessed for depression and obesity/diabetes independent of whether sleep- disordered breathing is present.
Archives of Internal MedicineThe Natural History of Insomnia
483 Citations2009Charles M. Morin, Lynda Bélanger +7 more
Findings indicate that insomnia is often a persistent condition, in particular when it reaches the diagnostic threshold for an insomnia disorder.
Journal of Psychosomatic ResearchChronic insomnia and activity of the stress system
395 Citations1998Alexandros N. Vgontzas, Constantine Tsigos +6 more
It is concluded that, in chronic insomnia, the activity of both limbs of the stress system (i.e., the HPA axis and the sympathetic system) relates positively to the degree of objective sleep disturbance.
Sleep Medicine ReviewsLongitudinal associations between sleep duration and subsequent weight gain: A systematic review
355 Citations2011Lorrie Magee, Lauren Hale
While shorter sleep duration consistently predicts subsequent weight gain in children, the relationship is not clear in adults, and studies with children more consistently reported a positive relationship between short sleep duration and weight gain.
Obesity ReviewsShort sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence
341 Citations2010Lunde Nielsen, Karen Vagner Danielsen +1 more
In conclusion, causal interpretation of the association between short sleep duration and obesity is hampered by fundamental conceptual and methodological problems and adequate coverage of the entire pathway from sleep curtailment through obesity development is not feasible.
Archives of Internal MedicineObesity Without Sleep Apnea Is Associated With Daytime Sleepiness
329 Citations1998Alexandros N. Vgontzas, Edward O. Bixler +4 more
It is suggested that daytime sleepiness in obese patients is a result of a circadian abnormality rather than just being secondary to nighttime sleep disturbance, which is a morbid characteristic of obese patients.
Sleep MedicineRisk factors for incident chronic insomnia: A general population prospective study
268 Citations2012Ravi Singareddy, Alexandros N. Vgontzas +5 more
Focusing on more vulnerable groups and addressing the modifiable risk factors may help reduce the incident of chronic insomnia, a common and chronic sleep disorder associated with significant medical and psychiatric morbidity and mortality.
American Journal of EpidemiologyCross-sectional and Longitudinal Associations Between Objectively Measured Sleep Duration and Body Mass Index: The CARDIA Sleep Study
234 Citations2009Diane S. Lauderdale, Kristen L. Knutson +4 more
A cross-sectional association between sleep duration and BMI was confirmed using objective sleep measures, but it was confirmed that sleep predicted change in BMI, but it was not found that sleep predicted change in BMI.
International Journal of ObesityShort sleep duration and obesity: the role of emotional stress and sleep disturbances
223 Citations2008Alexandros N. Vgontzas, H-M Lin +5 more
Self-reported short sleep duration in obese individuals may be a surrogate marker of emotional stress and subjective sleep disturbances, whose detection and management should be the focus of the preventive and therapeutic strategies for obesity.
Medical Clinics of North AmericaImpact of Obesity on Cardiovascular Disease
216 Citations2011Kerstyn C. Zalesin, Barry A. Franklin +3 more
Obesity promotes a cascade of secondary pathologies including diabetes, insulin resistance, dyslipidemia, inflammation, thrombosis, hypertension, the metabolic syndrome, and OSA which collectively heighten the risk for cardiovascular disease.
Journal of Psychosomatic ResearchInsomnia in Central Pennsylvania
203 Citations2002Edward O. Bixler, Alexandros N. Vgontzas +3 more
The findings support the conclusion that mental health variables have the primary independent association with a complaint of insomnia, and other factors including minorities and hypertension are also independently associated, though to a lesser degree.
SLEEPDaytime Sleepiness in Obesity: Mechanisms Beyond Obstructive Sleep Apnea—A Review
175 Citations2012Lori A. Panossian, Sigrid C. Veasey
This review critically examines the relationships between sleepiness, feeding, obesity, and sleep apnea and then discusses the hormonal, metabolic, and inflammatory mechanisms potentially contributing to hypersomnolence in obesity, independent of sleep Apnea and other established causes of excessive daytime sleepiness.
Sleep Medicine ReviewsThe reciprocal interaction between obesity and obstructive sleep apnoea
147 Citations2012Chong Weng Ong, Denise M. O’Driscoll +3 more
Current evidence does not confirm that treatment of OSA directly influences weight loss, but it does suggest that the potential role OSA plays in obesity and weight loss deserves further research.
SLEEPClinical and Polysomnographic Predictors of the Natural History of Poor Sleep in the General Population
119 Citations2012Julio Fernández‐Mendoza, Alexandros N. Vgontzas +7 more
It is suggested that objective short sleep duration in poor sleepers is a biologic marker of genetic predisposition to chronic insomnia.
SLEEPPersistent Insomnia: the Role of Objective Short Sleep Duration and Mental Health
112 Citations2011Alexandros N. Vgontzas, Julio Fernández‐Mendoza +7 more
Objective short sleep duration and mental health problems are the strongest predictors of persistent insomnia and further support the validity and clinical utility of objective shortSleep duration as a novel marker of the biological severity of insomnia.
Journal of Internal MedicineInsomnia, metabolic rate and sleep restoration
101 Citations2003Michael H. Bonnet, Donna L. Arand
Bonnet MH, Arand DL (Wright State University, Kettering Medical Center, and Wallace Kettering Neuroscience Institute, Dayton, OH, USA).
ObesitySleep duration and weight change in midlife women: The SWAN sleep study
73 Citations2013Bradley M. Appelhans, İmke Janssen +6 more
The associations of sleep duration with current BMI and BMI change were examined among 310 midlife women in the Study of Women's Health Across the Nation (SWAN) Sleep Study.