HEPATITIS‐ASSOCIATED ANTIGEN IN ABORIGINAL GROUPS IN NORTHERN AUSTRALIA
The Medical Journal of AustraliaPublished 1 August 1972
Eugene J. Barrett
Citations14
SJR quartileQ1
SJR score1.51
SNIP1.48
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TL;DR
Immunodiffusion tests detected hepatitis‐associated antigen in Australian Aboriginal adults and children and in Torres Strait Islander adults and adults, in a much higher proportion of the communities than has been found in Australian blood donors.
Abstract
Immunodiffusion tests detected hepatitis-associated antigen in Australian Aboriginal adults (13 of 160) and children (25 of 731), and in Torres Strait Islander adults (11 of 79), in a much higher proportion of the communities than has been found in Australian blood donors.
Keywords
Medicine
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The antigen was not an invariable serum antigen in patients who received blood transfusion and in patients with viral hepatitis, and the antibodies against Australia antigen were found not only in the recipients of Australia antigen positive but also of Australia antibody negative blood.
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Family studies involving 1797 different individuals residing on the island of Bougainville are consistent with the hypothesis that susceptibility to chronic infection with the "antigen" is controlled by an autosomal recessive gene (Au(1), which confirms the conclusions previously arrived at from similar (but less extensive) studies on the Island of Cebu.
BMJAustralia Antigen in Chronic Hepatitis in Australia
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It is suggested that active chronic hepatitis and lupoid hepatitis may follow infection of susceptible individuals with Au (1)-positive hepatitis virus, but persistence of the virus in high titre does not appear to be necessary for chronicity of the disease.
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This survey of health in Aboriginal children on 12 settlements and missions in Queensland suggests an infant mortality rate six times higher than the Queensland average, with diarrhoeal disease, respiratory infection, and diseases of the neonatal period accounting for 75% of infant deaths.
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Six blood donors at the Sydney Red Cross Blood Transfusion Service are being screened for the presence of Australia (Au) antigen; six had evidence of liver damage and at least two subsequently developed icteric hepatitis.
The Journal of Infectious DiseasesEpidemiologic Patterns of Viral Hepatitis in Eastern Europe in the Light of Recent Findings Concerning the Serum Hepatitis Antigen
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This rather exceptional situation warrants, within reasonable limits, an opportunity for assessment, comparison, and interpretation of epidemiologic patterns of viral hepatitis in the entire region.
The Journal of ImmunologyComplement Fixation and Immunodiffusion Tests for Assay of Hepatitis-Associated “Australia” Antigen and Antibodies
22 Citations1970Nathalie J. Schmidt, Edwin H. Lennette
Only a low proportion of sera from hepatitis patients in this study showed anti-complementary activity, and the activity was not reversed by an excess of Au antigen, although in some instances it was reduced by treatment with either antigen-containing or negative human sera.
PathologyAustralia antigen and viral hepatitis: a brief review and a preliminary australian report
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Australia antigen was detected in 5 of 10 patients with post‐transfusion hepatitis, in 3 of 93 patients with acute viral hepatitis unrelated to transfusion, in 2 of 17 patients with chronic hepatitis, In 8 of 32 institutionalized patients with Down's syndrome, and in 1 member on the staff of a dialysis unit when the recipient developed viral hepatitis.
The Medical Journal of AustraliaAUSTRALIA ANTIGEN AND VIRAL HEPATITIS IN SYDNEY: A HOSPITAL SERIES
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The Australia antigen was found to be associated with 19·8% of cases of acute viral hepatitis in a hospital series in Sydney and was found more frequently with transfusion‐associated hepatitis than with non‐ transfusions‐assoclated hepatitis.
The Medical Journal of AustraliaHIGH‐VOLTAGE IMMUNOELECTROOSMOPHORESIS IN AUSTRALIA ANTIGEN SCREENING OF BLOOD DONORS
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Immunoelectroosmophoresis screening of Queensland Red Cross blood donors for Australia antigen has revealed an incidence of 0.07%.
The Medical Journal of AustraliaAUSTRALIA ANTIGEN IN ACUTE HEPATITIS IN MELBOURNE
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Australia antigen was detected in 6·6% of 436 cases of acute viral hepatitis seen over an eight‐month period at Fairfield Hospital for Communicable Diseases, Melbourne, lower than has been found in some centres in the United States.
