The inhibition of catecholamine biosynthesis by apomorphine
Journal of Pharmacy and PharmacologyPublished 1 September 1970
Menek Goldstein, Lewis S. Freedman, Tony Backstrom
Citations93
SJR quartileQ2
SJR score0.72
SNIP0.73
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Striatal slices are more sensitive to the inhibition of [14C]dopamine biosynthesis by apomorphine than tyrosine hydroxylase preparations obtained either from bovine adrenal glands or from the striatum of rats, and the inhibition by apomorphicine is more effective.
Abstract
Menek Goldstein, Lewis S Freedman, Tony Backstrom; The inhibition of catecholamine biosynthesis by apomorphine, Journal of Pharmacy and Pharmacology, Volum
Keywords
ChemistryMedicine
Journal of Pharmacy and PharmacologyEvidence for dopamine receptor stimulation by apomorphine
913 Citations1967Nils‐Erik Andén, A. Rubenson +2 more
Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.
PsychopharmacologyMode of action of apomorphine and dexamphetamine on gnawing compulsion in rats
909 Citations1967A. M. Ernst
The action of apomorphine on gnaw compulsion is, just as that of dopamine, directly on effect receptors, and may act as a substitute for dopamine deficiency in Parkinson's disease.
Cellular and Molecular Life SciencesSite of action of dopamine and apomorphine on compulsive gnawing behaviour in rats
331 Citations1966A. M. Ernst, P. G. Smelik
Es wird die Relation von Struktur und Wirkung zwischen Dopamin und Apomorphin beim Zwangsnagen der Ratte, nach stereotaktischer Implantation der beiden Substanzen besprochen.
New England Journal of MedicineSimilarities between Neurologic Effects of L-Dopa and of Apomorphine
272 Citations1970George C. Cotzias, Paul S. Papavasiliou +3 more
L-DOPA is a precursor for the biosynthesis of both melanins and catecholamines and both groups of substances are diminished within the Parkinsonian brain.
European Journal of PharmacologyEffects of apomorphine and amphetamine on schedule-controlled behavior: Reversal of tetrabenazine suppression and dopaminergic correlates
59 Citations1969Larry L. Butcher, Nils‐Erik Andén
Injection of 1.5 mg/kg tetrabenazine (TBZ) abolished lever-pressing in rats maintained on a variable-interval schedule of food reinforcement, correlated with a decrease in central dopamine, noradrenaline, and 5-hydroxytryptamine levels.
