Shortened survival in infants vertically infected with human immunodeficiency virus with elevated p24 antigenemia
The Journal of PediatricsPublished 1 October 1995
Nina Arlievsky, Henry Pollack, Mona Rigaud, Aditya Kaul, Keith Krasinski, William Borkowsky
Citations18
SJR quartileQ1
SJR score1.01
SNIP1.11
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TL;DR
Elevated p24 antigenemia in the first 6 months of life is associated with shorter survival and may be a useful predictor of outcome.
Abstract
Elevated p24 antigenemia in the first 6 months of life is associated with shorter survival and may be a useful predictor of outcome.
Keywords
Immunology and MicrobiologyMedicine
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The rapid and spontaneous decline in the viral load suggests an effective immune response in the host that, if understood, may be used to combat AIDS.
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A subgroup of patients expressed very early signs of severe immunodeficiency and encephalopathy, whereas the majority of patients had a longer survival and less severe clinical symptoms during their first years of life than previously thought.
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Improved detection and quantitation of p24 antigen of the human immunodeficiency virus (HIV) in sera was obtained by pH 2.5-3.0 pretreatment of samples before using a standard HIV p22 antigen ELISA, and direct comparison of the pretreatment with the conventional assay demonstrated substantial increase in both antigen positivity and level.
The LancetFeatures of children perinatally infected with HIV-1 surviving longer than 5 years
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The study shows that aCD4 cell decrease early in life can be predictive of outcome, and a substantial number of children do survive after early childhood; severe diseases; low CD4 cell numbers, and p24 antigenaemia do not necessarily preclude long-term survival.
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It is suggested that a direct relationship exists between HIV replication, the timing of transmission and onset and progression of HIV disease in vertically infected children.
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The persistent antigenemia in children indicates that their immune systems cannot restrict HIV expression as efficiently as those of adults.
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In a series of 97 infants born to mothers who were seropositive for human immunodeficiency virus type 1, 18 were identified as infected within the first 60 days of life on the basis of viral culture and polymerase chain reaction findings, and it was found that children with S/L isolates harbored mainly monocytotropic variants.
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The CD4-positive T-lymphocyte count increased at low ddl concentrations or exposures; the extent of this increase was directly proportional to the patient's CD4 count at the start of therapy, and therapeutic responses can probably be obtained with ddl.
Proceedings of the National Academy of SciencesOntogeny of anti-human immunodeficiency virus (HIV) antibody production in HIV-1-infected infants.
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M measuring HIV antibody produced in vitro by lymphocytes isolated from peripheral blood of infants and children of HIV-1-infected mothers has been able to study the natural acquisition of humoral immunity to perinatal HIV- 1 infection and of assessing the effect of early therapeutic interventions on the humoral response to HIV-2.
The Journal of Infectious DiseasesSerum p24 Antigen Level as an Intermediate End Point in Clinical Trials of Zidovudine in People Infected with Human Immunodeficiency Virus Type 1
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Pretreatment serum p24 antigen levels were predictive of clinical outcome in subjects from three clinical trials of zidovudine; subsequent measurements appear to be of limited use in evaluating zidvudine therapy.
The Journal of PediatricsEfficacy of primary chemoprophylaxis against Pneumocystis carinii pneumonia during the first year of life in infants infected with human immunodeficiency virus type 1
22 Citations1994Mona Rigaud, Henry Pollack +8 more
It is indicated that chemoprophylaxis is highly effective in preventing primary PCP and improving survival time in infants with human immunodeficiency virus-1 infection.
American journal of diseases of childrenCD4 Status and P24 Antigenemia
21 Citations1992Karina Butler
The association between low CD4 counts and death suggests that the age-adjusted CD4 count should be used as a marker to guide therapeutic intervention and the presence of a very low CD 4 count alone should not be considered a reason for therapeutic nihilism.
Sexually Transmitted InfectionsHIV-1 P24 antigenaemia does not predict time of survival in AIDS patients.
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HIV-1 p24 antigenaemia at the moment of diagnosis of AIDS (both in the period before and in theperiod after the introduction of zidovudine) is not a predictor for time of survival.
