Rho kinase blockade prevents inflammation via nuclear factor κB inhibition: evidence in Crohn’s disease and experimental colitis
GastroenterologyPublished 1 May 2003Open access
Jean‐Pierre Segain, Diane Raingeard de la Blétière, Vincent Sauzeau, Arnaud Bourreille, Gréory Hilaret, Chrystelle Cario‐Toumaniantz
Citations187
SJR quartileQ1
SJR score7.20
SNIP5.04
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TL;DR
This study provides the first evidence that Rho kinase activates I-kappa B kinase and, thus, nuclear factor kappa B, suggesting a key role of Rho Kinase in inflammatory responses and intestinal inflammation.
Abstract
Our study provides the first evidence that Rho kinase activates I-kappa B kinase and, thus, nuclear factor kappa B, suggesting a key role of Rho kinase in inflammatory responses and intestinal inflammation. Specific inhibition of Rho kinase may be a promising approach for the treatment of patients with Crohn's disease.
Keywords
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