Cost-Benefit Analysis of the Detection of Prescribing Errors by Hospital Pharmacy Staff
Drug SafetyPublished 1 January 2002
Patricia M. L. A. van den Bemt, Maarten J. Postma, Eric N. van Roon, M Chow, Roel Fijn, J. R. B. J. Brouwers
Citations75
SJR quartileQ1
SJR score1.13
SNIP1.34
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It can be concluded that prevention of prescribing errors by hospital pharmacy staff results in higher benefits than the costs related to the net time investment, and was robust in sensitivity analysis.
Abstract
From this study it can be concluded that prevention of prescribing errors by hospital pharmacy staff results in higher benefits than the costs related to the net time investment.
Keywords
MedicineHealth Professions
New England Journal of MedicineThe Nature of Adverse Events in Hospitalized Patients
3,750 Citations1991Lucian L. Leape, Troyen A. Brennan +8 more
The high proportion that are due to management errors suggests that many others are potentially preventable now, and reducing the incidence of these events will require identifying their causes and developing methods to prevent error or reduce its effects.
JAMAIncidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group
2,509 Citations1995David W. Bates
Adverse drug events were common and often preventable; serious ADEs were more likely to be preventable and prevention strategies should target both stages of the drug delivery process.
JAMAEffect of Computerized Physician Order Entry and a Team Intervention on Prevention of Serious Medication Errors
2,091 Citations1998David W. Bates
Physician computer order entry decreased the rate of nonintercepted serious medication errors by more than half, although this decrease was larger for potential ADEs than for errors that actually resulted in an ADE.
JAMAPharmacist Participation on Physician Rounds and Adverse Drug Events in the Intensive Care Unit
1,575 Citations1999Lucian L. Leape
The presence of a pharmacist on rounds as a full member of the patient care team in a medical ICU was associated with a substantially lower rate of ADEs caused by prescribing errors.
PubMedIncidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group.
1,109 Citations1995D W Bates, Cullen Dj +8 more
BMJVariability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis
827 Citations1996David Henry, L. Lim +10 more
The low risk of serious gastrointestinal complications with ibuprofen seems to be attributable mainly to the low doses of the drug used in clinical practice, and in higher doses ib uprofen is associated with a similar risk to other non-steroidal anti-inflammatory drugs.
Journal of Antimicrobial ChemotherapyFlucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
793 Citations2000András Vermes
5-FC is a synthetic antimycotic compound that has no intrinsic antifungal capacity, but after it has been taken up by susceptible fungal cells, it is converted into 5-fluorouracil (5-FU), which is further converted to metabolites that inhibit fungal RNA and DNA synthesis.
PubMedThe costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group.
658 Citations1997David W. Bates, N Spell +7 more
International Journal of Trauma NursingIncidence of adverse drug events and potential adverse drug events
538 Citations1995D. W. Bates, David J. Cullen +1 more
The LancetUnfractionated heparin and low-molecular-weight heparin in acute coronary syndrome without ST elevation: a meta-analysis
442 Citations2000John W. Eikelboom, Sonia S. Anand +4 more
In aspirin-treated patients with acute coronary syndrome without ST elevation, short-term unfractionated heparin or LMWH halves the risk of myocardial infarction or death and long-term LMWH has not been proven to confer benefit additional to aspirin and there is no evidence to support its use after the first 7 days.
PubMedAntifungal drug resistance in pathogenic fungi.
292 Citations1998H. Vanden Bossche, Françoise Dromer +4 more
In azole-resistant C. albicans isolates from AIDS patients with oropharyngeal candidiasis, multidrug efflux transporters of the ATP-binding cassette (ABC) superfamily and of the class of major facilitators (MF) have been shown to be responsible for the low level of accumulation of azole antifungal agents.
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyClinical Pharmacy Services and Hospital Mortality Rates
217 Citations1999Christopher Bond, Cynthia L. Raehl +1 more
BMJImplementation of rules based computerised bedside prescribing and administration: intervention study
201 Citations2000Peter Nightingale
The computerised prescribing system assists clinicians when they are writing a prescription by making available information on patients and has been well received by doctors, nurses, and pharmacists.
Drug SafetyDrug-Related Problems in Hospitalised Patients
200 Citations2000Patricia M. L. A. van den Bemt, Toine C. G. Egberts +2 more
An overview of studies on drug-related problems in hospitalised patients, with specific attention to the incidence of drug- related problems and their costs, to the possibilities of prevention and to the effect of these interventions, is performed.
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyClinical Pharmacy Services, Pharmacy Staffing, and the Total Cost of Care in United States Hospitals
152 Citations2000Christopher Bond, Cynthia L. Raehl +1 more
It is suggested that increased staffing levels of clinical pharmacists and pharmacy administrators, as well as some clinical pharmacy services, were associated with reduced total cost of care in United States hospitals.
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyHealth Care Professional Staffing, Hospital Characteristics, and Hospital Mortality Rates
145 Citations1999Christopher Bond, Cynthia L. Raehl +2 more
To the authors' knowledge, this is the first study to show that pharmacists were associated with lower mortality rates, and hospital characteristics associated withLower mortality were occupancy rate and private nonprofit and private for‐profit ownership.
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyClinical Pharmacy Services, Pharmacist Staffing, and Drug Costs in United States Hospitals
110 Citations1999Christopher Bond, Cynthia L. Raehl +1 more
Increased staff levels of clinical pharmacists and some clinical pharmacy services are associated with reduced hospital drug costs, and as staffing increased for hospital pharmacy administrators, drug costs increased and decreased.
Clinical Infectious DiseasesFlucytosine Monotherapy for Cryptococcosis
75 Citations1998Duane R. Hospenthal, John E. Bennett
Although the 57% failure rate associated with 5-FC alone precludes its use as monotherapy, this study did show that this treatment was well tolerated and that failure was not invariably associated with development of resistance.
Antimicrobial Agents and ChemotherapyEfficacies of High-Dose Fluconazole plus Amphotericin B and High-Dose Fluconazole plus 5-Fluorocytosine versus Amphotericin B, Fluconazole, and 5-Fluorocytosine Monotherapies in Treatment of Experimental Endocarditis, Endophthalmitis, and Pyelonephritis Due to <i>Candida albicans</i>
71 Citations1999Arnold Louie, Weiguo Liu +6 more
The efficacies of fluconazole, amphotericin B (AmB), and 5-fluorocytosine monotherapies with the combination of Flu plus 5FC and Flu plus AmB in a rabbit model of Candida albicans endocarditis, endophthalmitis, and pyelonephritis were compared.
Survey of AnesthesiologyThe Costs of Adverse Drug Events in Hospitalized Patients
67 Citations1998David W. Bates, Nathan O. Spell +7 more
The substantial costs of ADEs to hospitals justify investment in efforts to prevent these events, and conservative estimates suggest that the annual costs attributable to all ADEs and preventable ADEs for a 700-bed teaching hospital are $5.6 million and $2.8 million, respectively.
ThoraxComparison between irrigation and conventional treatment for empyema and pneumonectomy space infection.
65 Citations1981Franklin Rosenfeldt, D McGibney +2 more
Cyclical irrigation resulted in a shorter hospital stay and a shorter period of wound drainage than other methods, and was compared with the results of aspiration, open drainage, decortication, or thoracoplasty.
Journal of Cardiovascular PharmacologyRespiratory Tolerance of Bisoprolol and Metoprolol in Asthmatic Patients
23 Citations1985JW Lammers, H. Folgering +1 more
There were no differences between the responses of FEV1, VC, and PEFR to terbutaline with any of the &bgr;‐blockers, indicating a good degree of &bGr;1‐adrenoceptor selectivity of 10 and 20 mg bisoprolol and 100 mg metoprolols in humans.
PubMedEvaluating the potential effectiveness of using computerized information systems to prevent adverse drug events.
22 Citations1997James G. Anderson, S J Jay +2 more
It is suggested that system-wide changes to the drug-ordering and delivery system are required to significantly reduce adverse drug events in a hospital setting.
CHEST JournalAmikacin Concentrations in Uninfected Postthoracotomy Pleural Fluid and in Serum After Intravenous and Intrapleural Injection
15 Citations1984Jean-P. Thys, E. Serruys-Schoutens +4 more
The pharmacokinetics of amikacin after intravenous (IV) and intrapleural injection was compared in 25 patients with pleural drainage after lung resection and the pleural fluid concentrations were extremely high and well sustained during eight hours; however, serum concentrations reached maximal values of 14.1 +/- 4.7 micrograms/ml, indicating a substantial diffusion of amkacin from the Pleural space to the blood.
The Annals of Thoracic SurgeryA Method of Early Irrigation of the Contaminated Postpneumonectomy Space
6 Citations1981Nevin Katz, Richard B. McElvein
A modified balanced drainage system was used with other measures in a patient with an obstructing pulmonary carcinoma, infection, and necrosis, and the patient recovered without evidence of empyema and died of a cerebral metastasis five and a half months postoperatively.
