Enantioselective Construction of Vicinal Sulfur‐containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich‐Type Addition of Rhodanines to Isatin Imines
Advanced Synthesis & CatalysisPublished 23 June 2018Open access
Qiuhong Huang, Lili Zhang, Yuyu Cheng, Pengfei Li, Wenjun Li
Citations33
SJR quartileQ1
SJR score0.93
SNIP0.92
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Abstract
Abstract The catalyzed enantioselective nucleophilic addition of rhodanines has been established by employing isatin‐derived imines as suitable partners under chiral squaramide catalysis. By using this strategy, the resulting 3‐substituted 3‐amino‐2‐oxindoles featuring both rhodanine and vicinal sulfur‐containing tetrasubstituted stereocenters structural motifs were obtained in high yields with excellent enantioselectivities and diastereoselectivities. magnified image
Keywords
Chemistry
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