Chiral Brønsted Acid‐Mediated Enantioselective Organocatalytic Three‐Component Reaction for the Construction of Trifluoromethyl‐Containing Molecules
Advanced Synthesis & CatalysisPublished 23 June 2008
Guangwu Zhang, Lian Wang, Jing Nie, Jun‐An Ma
Citations121
SJR quartileQ1
SJR score0.93
SNIP0.92
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Abstract
Abstract In combination with the advantages of organocatalysis, we have developed a highly enantioselective Friedel–Crafts aminoalkylation of indoles with imines generated in situ from trifluoroacetaldehyde methyl hemiacetal and aniline. Novel chiral trifluoromethyl‐containing compounds were obtained in high yields with excellent enantioselectivities. This methodology was further extended to difluoroacetaldehyde methyl hemiacetal to demonstrate the broad scope of substrates.
Keywords
ChemistryBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and Pharmaceutics
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