A bibliometric analysis of the 100 most influential papers on COPD
International Journal of COPDPublished 1 March 2015Open access
Xiaoyan Jin, Wenchao Gu, Yaping Yuan, Hua Yang, Guang-sheng Qi, Yan Jin
Citations23
SJR quartileQ1
SJR score0.97
SNIP1.10
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TL;DR
Bibliometric analysis provides a historical perspective on the progress of scientific research on COPD research over the past decades and indicates articles originating from the United States and published in high-impact specialized respiratory journals are most likely to be cited in the field of COPDResearch.
Abstract
Our bibliometric analysis provides a historical perspective on the progress of scientific research on COPD. Articles originating from the United States and published in high-impact specialized respiratory journals are most likely to be cited in the field of COPD research.
Keywords
Social SciencesMedicine
American Journal of Respiratory and Critical Care MedicineGlobal Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
16,096 Citations2012Jørgen Vestbo, Suzanne S. Hurd +11 more
It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
American Journal of Respiratory and Critical Care MedicineGlobal Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
4,686 Citations2007Klaus F. Rabe, Suzanne S. Hurd +9 more
The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.
European Respiratory JournalStandards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
4,383 Citations2004Bartolomé R. Celli, William MacNee +24 more
The main goals of the updated document are to improve the quality of care provided to patients with COPD and to develop the project using a disease-oriented approach.
New England Journal of MedicineThe Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease
4,043 Citations2004Bartolomé R. Celli, Claudia Côté +6 more
The BODE index, a simple multidimensional grading system, is better than the FEV1 at predicting the risk of death from any cause and from respiratory causes among patients with COPD.
New England Journal of MedicineThe Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
3,754 Citations2004James C. Hogg, Fanny Chu +9 more
Progression of COPD is associated with the accumulation of inflammatory mucous exudates in the lumen and infiltration of the wall by innate and adaptive inflammatory immune cells that form lymphoid follicles, coupled to a repair or remodeling process that thickens the walls of these airways.
New England Journal of MedicineSalmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease
3,226 Citations2007Peter Calverley, Julie A. Anderson +6 more
The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
New England Journal of MedicineSusceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
2,899 Citations2010John R. Hurst, Jørgen Vestbo +12 more
Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype, which has implications for the targeting of exacerbation-prevention strategies across the spectrum of disease severity.
ThoraxUsefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease
2,830 Citations1999Janine Bestall, Elizabeth Paul +4 more
The MRC dyspnoea scale is a simple and valid method of categorising patients with COPD in terms of their disability that could be used to complement FEV1 in the classification of COPD severity.
Cambridge University Press eBooksChronic Obstructive Pulmonary Disease
2,699 Citations2018Kate Flavin, Clare Morkane +1 more
Several meetings of chest specialists were held in order to update basic knowledge on Chronic Obstructive Pulmonary Disease and to establish guidelines regarding its prevention and treatment and strategies directed to smoking cessation are described.
Annals of Internal MedicineAntibiotic Therapy in Exacerbations of Chronic Obstructive Pulmonary Disease
2,477 Citations1987N. R. Anthonisen, J. MANFREDA +4 more
There was a significant benefit associated with antibiotic and Peak flow recovered more rapidly with antibiotic treatment than with placebo, and side effects were uncommon and did not differ between antibiotic and placebo.
BMJWhy the impact factor of journals should not be used for evaluating research
2,448 Citations1997Per O. Seglen
The LancetInternational variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study
2,351 Citations2007A. Sonia Buist, Mary Ann McBurnie +12 more
This worldwide study showed higher levels and more advanced staging of spirometrically confirmed COPD than have typically been reported and variations in disease prevalence-other factors also seem to be important.
American Journal of Respiratory and Critical Care MedicineEffect of Exacerbation on Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
2,328 Citations1998TERENCE A. R. SEEMUNGAL, Gavin C. Donaldson +4 more
It is suggested that patient quality of life is related to COPD exacerbation frequency and factors predictive of frequent exacerbations were daily cough, daily wheeze, and daily cough and sputum.
ThoraxRelationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
2,253 Citations2002Gavin C. Donaldson
It is suggested that the frequency of exacerbations contributes to long term decline in lung function of patients with moderate to severe COPD.
New England Journal of MedicineA 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease
2,199 Citations2008Donald P. Tashkin, Bartolomé R. Celli +5 more
Therapy with tiotropium was associated with improvements in lung function, quality of life, and exacerbations during a 4-year period but did not significantly reduce the rate of decline in FEV(1).
The LancetGlobal burden of COPD: risk factors, prevalence, and future trends
2,085 Citations2007David M. Mannino, A. Sonia Buist
Advances in understanding of COPD are increased recognition of the importance of comorbid disease, identification of different COPD phenotypes, and understanding how factors other than lung function affect outcome in patients.
New England Journal of MedicineNoninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease
2,039 Citations1995Laurent Brochard, Jordi Mancebo +10 more
In selected patients with acute exacerbations of chronic obstructive pulmonary disease, noninvasive ventilation can reduce the need for endotracheal intubation, the length of the hospital stay, and the in-hospital mortality rate.
ThoraxSevere acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
1,922 Citations2005Juan José Soler‐Cataluña
ThoraxAssociation between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
1,803 Citations2004Wenqi Gan
Reduced lung function is associated with increased levels of systemic inflammatory markers which may have important pathophysiological and therapeutic implications for subjects with stable COPD.
European Respiratory JournalSystemic manifestations and comorbidities of COPD
1,800 Citations2009Peter J. Barnes, Bartolomé R. Celli
Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities, however, new broad-spectrum anti-inflammatory treatments, such as phosphodiesterase 4 inhibitors, have significant side-effects so it may be necessary to develop inhaled drugs in the future.
BMJRandomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial
1,684 Citations2000PS Burge
Improvements in clinical outcomes support the use of this treatment in patients with moderate to severe chronic obstructive pulmonary disease as patients on fluticasone propionate had fewer exacerbations and a slower decline in health status.
European Respiratory JournalOptimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force
1,593 Citations1995NM Siafakas, P. Vermeire +9 more
The guidelines are intended for use by physicians involved in the care of patients with COPD, and their main goals are to inform health professionals and to reverse a widespread nihilistic approach to the management of these patients.
European Respiratory JournalGlobal burden of COPD: systematic review and meta-analysis
1,490 Citations2006Ronald J. Halbert, Jaime L. Natoli +4 more
The aim of this study was to quantify the global prevalence of chronic obstructive pulmonary disease by means of a systematic review and random effects meta-analysis and population-based prevalence estimates published during the period 1990–2004.
European Respiratory JournalChronic obstructive pulmonary disease: molecular and cellularmechanisms
1,429 Citations2003Peter J. Barnes, SD Shapiro +1 more
The inflammation and proteolysis in chronic obstructive pulmonary disease is an amplification of the normal inflammatory response to cigarette smoke, prompting a search for novel anti-inflammatory therapies that may prevent the relentless progression of the disease.
Nature reviews. ImmunologyImmunology of asthma and chronic obstructive pulmonary disease
1,379 Citations2008Peter J. Barnes
It is now becoming clear that the distinction between these diseases becomes blurred in patients with severe asthma, in asthmatic subjects who smoke and during acute exacerbations, which has important implications for the development of new therapies.
American Journal of Respiratory and Critical Care MedicineDifferences in Interleukin-8 and Tumor Necrosis Factor-Alpha in Induced Sputum From Patients With Chronic Obstructive Pulmonary Disease or Asthma
1,372 Citations1996Vera M. Keatings, Paul Collins +2 more
A significant increase in neutrophils and increased concentrations of tumor necrosis factor-alpha (TNF alpha) and interleukin-8 (IL-8) in the patients with COPD compared with the smoking and nonsmoking control subjects means that the cytokines TNF alpha and IL-8 may be involved in the inflammation in COPD.
European Respiratory JournalChronic obstructive pulmonary disease: current burden and future projections
1,333 Citations2006Alan D López, Kenji Shibuya +6 more
A summary measure, disability-adjusted life yrs (DALYs), has been developed to simultaneously measure the amount of disease burden due to premature mortality and the amount due to the nonfatal consequences of disease.
American Journal of Respiratory and Critical Care MedicineCharacteristics of Physical Activities in Daily Life in Chronic Obstructive Pulmonary Disease
1,267 Citations2005Fábio Pitta, Thierry Troosters +4 more
Physical activities and movement intensity in patients with chronic obstructive pulmonary disease are assessed with the DynaPort activity monitor and functional exercise capacity is the strongest correlate of physical activities in daily life.
The LancetPathophysiology of airflow limitation in chronic obstructive pulmonary disease
1,249 Citations2004James C. Hogg
The technology needed to diagnose and quantitate the individual small airway and emphysema phenotypes present in people with COPD is being developed, and should prove helpful in the assessment of therapeutic interventions designed to modify the progress of either phenotype.
The LancetCombined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
1,220 Citations2003Peter M.A. Calverley, Romain Pauwels +6 more
The LancetEarly use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial
1,217 Citations2000PK Plant, JL Owen +1 more
The early use of NIV for mildly and moderately acidotic patients with COPD in the general ward setting leads to more rapid improvement of physiological variables, a reduction in the need for invasive mechanical ventilation (with objective criteria), and a reduced in-hospital mortality.
New England Journal of MedicineAzithromycin for Prevention of Exacerbations of COPD
1,207 Citations2011Richard Albert, John E. Connett +23 more
Among selected subjects with COPD, azithromycin taken daily for 1 year, when added to usual treatment, decreased the frequency of exacerbations and improved quality of life but caused hearing decrements in a small percentage of subjects.
American Journal of Respiratory and Critical Care MedicineTime Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
1,182 Citations2000Terence Seemungal, Gavin C. Donaldson +3 more
Symptom changes during exacerbation do not closely reflect those of lung function, but their increase may predict exacerbation, with dyspnea or colds characterizing the more severe.
Respiratory ResearchCharacterisation of COPD heterogeneity in the ECLIPSE cohort
1,160 Citations2010the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Àlvar Agustí +13 more
The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
American Journal of Respiratory and Critical Care MedicineWeight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
1,094 Citations1998Annemie M.W.J. Schols, Jos J. M. Slangen +2 more
The objective of the study was to further unravel the prognostic significance of body weight changes in patients with COPD and to quantify the relationship between the baseline ...
CirculationWhy Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases?
1,082 Citations2003Don D. Sin, S. F. Paul Man
Low-grade systemic inflammation was present in participants with moderate to severe airflow obstruction and was associated with increased risk of cardiac injury, which may in part explain the high rates of cardiovascular complications in COPD.
New England Journal of MedicineLong-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking
1,080 Citations1999Romain Pauwels, Claes-Göran Löfdahl +5 more
A double-blind, placebo-controlled study evaluated the effect of the inhaled glucocorticoid budesonide in subjects with mild COPD who continued smoking and found that the FEV1 improved at the rate of 17 ml per year in the budesonid group, which was higher than the predicted value.
American Journal of Respiratory and Critical Care MedicineDynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
1,063 Citations2001Denis E. O’Donnell, Susan M. Revill +1 more
The role of dynamic hyperinflation in exercise limitation in chronic obstructive pulmonary disease (COPD) remains to be defined and the extent of DH during exercise in COPD correlated best with resting IC.
American Journal of Respiratory and Critical Care MedicineInfections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations
1,062 Citations2006Alberto Papi, Cinzia Maria Bellettato +6 more
Respiratory infections are associated with the majority of COPD exacerbations and their severity, especially those with viral/bacterial coinfection, and airway neutrophilia is related to exacerbation severity regardless of viral and/or bacterial infections.
New England Journal of MedicineNew Strains of Bacteria and Exacerbations of Chronic Obstructive Pulmonary Disease
1,055 Citations2002Sanjay Sethi, Nancy Evans +2 more
The association between an exacerbation and the isolation of a new strain of a bacterial pathogen supports the causative role of bacteria in exacerbations of chronic obstructive pulmonary disease.
European Respiratory JournalSystemic effects of chronic obstructive pulmonary disease
1,039 Citations2003Àlvar Agustí, A. Noguera +4 more
The present review discusses the following systemic effects of chronic obstructive pulmonary disease: systemic inflammation; 2) nutritional abnormalities and weight loss; 3) skeletal muscle dysfunction; and 4) other potential systemic effects.
American Journal of Respiratory and Critical Care MedicineChronic Obstructive Pulmonary Disease Phenotypes: The Future of COPD
1,039 Citations2010MeiLan K. Han, Àlvar Agustí +17 more
This work proposes the following variation on this definition of COPD phenotypes: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)."
American Journal of Respiratory and Critical Care MedicinePrognostic Value of Nutritional Status in Chronic Obstructive Pulmonary Disease
1,035 Citations1999CHARLOTTE LANDBO, Eva Prescott +3 more
It is concluded that low BMI is an independent risk factor for mortality inSubjects with COPD, and that the association is strongest in subjects with severe COPD.
American Journal of Respiratory and Critical Care MedicinePeripheral Muscle Weakness Contributes to Exercise Limitation in COPD
1,024 Citations1996Rik Gosselink, Thierry Troosters +1 more
American Journal of Respiratory and Critical Care MedicineRespiratory Viruses, Symptoms, and Inflammatory Markers in Acute Exacerbations and Stable Chronic Obstructive Pulmonary Disease
1,018 Citations2001Terence Seemungal, RHIAN HARPER-OWEN +9 more
Viral exacerbations were associated with frequent exacerbators, colds with increased dyspnea, a higher total symptom count at presentation, a longer median symptom recovery period of 13 d, and a tendency toward higher plasma fibrinogen and serum IL-6 levels.
The LancetChronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study
1,009 Citations2005Ana Maria B. Menezes, Rogelio Pérez‐Padilla +8 more
The results suggest that COPD is a greater health problem in Latin America than previously realised and given the high rates of tobacco use in the region, increasing public awareness of the burden of COPd is important.
The LancetBurden and clinical features of chronic obstructive pulmonary disease (COPD)
1,003 Citations2004Romain Pauwels, Klaus F. Rabe
COPD should be considered in any patient presenting with cough, sputum production, or dyspnoea, especially if an exposure to risk factors for the disease has been present, and continued exposure to noxious agents promotes a more rapid decline in lung function and increases the risk for repeated exacerbations.
CHEST JournalDyspnea Is a Better Predictor of 5-Year Survival Than Airway Obstruction in Patients With COPD
985 Citations2002Koichi Nishimura, Takateru Izumi +2 more
The categorization of patients with COPD on the basis of the level of dyspnea was more discriminating than staging of disease severity using the ATS guideline with respect to 5-year survival.
New England Journal of MedicineDecreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease
962 Citations2005Kazuhiro Ito, Misako Ito +9 more
Patients with COPD have a progressive reduction in total HDAC activity that reflects the severity of the disease, and this work has shown that HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages.
Archives of Internal MedicineReduction of Hospital Utilization in Patients With Chronic Obstructive Pulmonary Disease<subtitle>A Disease-Specific Self-management Intervention</subtitle>
945 Citations2003Jean Bourbeau
A continuum of self-management for COPD patients provided by a trained health professional can significantly reduce the utilization of health care services and improve health status.
European Respiratory JournalOxidative stress and redox regulation of lung inflammation in COPD
934 Citations2006Irfan Rahman, Ian M. Adcock
Oxidative stress regulates both key signal transduction pathways and histone modifications involved in lung inflammation and various approaches to enhance lung antioxidant capacity and clinical trials of antioxidant compounds in chronic obstructive pulmonary disease are discussed.
Annals of Internal MedicineEffects of Pulmonary Rehabilitation on Physiologic and Psychosocial Outcomes in Patients with Chronic Obstructive Pulmonary Disease
911 Citations1995Andrew L. Ries, Robert M. Kaplan +2 more
The effects of comprehensive pulmonary rehabilitation on both physiologic and psychosocial outcomes with the effects of education alone were compared with long-term, 6-year follow-up.
Journal of Thoracic and Cardiovascular SurgeryBilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease
900 Citations1995Jonathan D. Cooper, Elbert P. Trulock +6 more
Surgical bilateral lung volume reduction may be of significant value for selected patients with severe chronic obstructive pulmonary disease and marked relief of dyspnea and improvement in exercise tolerance and quality of life.
European Respiratory JournalEfficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease
889 Citations2003W Szafrański, Alberto Cukier +6 more
A role for budesonide/formoterol in the long-term management of moderate-to-severe chronic obstructive pulmonary disease is suggested and all treatments were well tolerated.
European Respiratory JournalA long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
886 Citations2002Richard Casaburi, Donald A. Mahler +7 more
Tiotropium is an effective, once-daily bronchodilator that reduces dyspnoea and chronic obstructive pulmonary disease exacerbation frequency and improves health status and that will make an important contribution to chronic obstructives pulmonary disease therapy.
New England Journal of MedicineEffect of Systemic Glucocorticoids on Exacerbations of Chronic Obstructive Pulmonary Disease
881 Citations1999Dennis E. Niewoehner, Marcia L. Erbland +6 more
The LancetMeta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease
862 Citations1996Yves Lacasse, Eric Wong +4 more
A meta-analysis of randomised controlled trials of respiratory rehabilitation in patients with COPD found that it relieves dyspnoea and improves the control over COPD, and the value of the improvement in exercise capacity is not clear.
European Respiratory JournalEffects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
859 Citations2004Denis E. O’Donnell, Thomas Flüge +6 more
Results show that the use of tiotropium was associated with sustained reductions of lung hyperinflation at rest and during exercise and contributed to improvements in both exertional dyspnoea and exercise endurance.
European Respiratory JournalOutcomes for COPD pharmacological trials: from lung function to biomarkers
857 Citations2008Mario Cazzola, William MacNee +22 more
The American Thoracic Society/European Respiratory Society jointly created a Task Force on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers.
American Journal of Respiratory and Critical Care MedicineThe Prevention of Chronic Obstructive Pulmonary Disease Exacerbations by Salmeterol/Fluticasone Propionate or Tiotropium Bromide
843 Citations2007Jadwiga A. Wedzicha, Peter M.A. Calverley +4 more
A small statistically significant beneficial effect was found on health status, with an unexpected finding of lower deaths in salmeterol/fluticasone propionate-treated patients.
American Journal of Respiratory and Critical Care MedicineOxidative Stress in Chronic Obstructive Pulmonary Disease
840 Citations1997John E. Repine, Aalt Bast +1 more
American Journal of Respiratory and Critical Care MedicineMidthigh Muscle Cross-Sectional Area Is a Better Predictor of Mortality than Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease
832 Citations2002Karine Marquis, Richard Debigaré +5 more
It is found that a reduction in midthigh muscle cross-sectional area obtained by CT scan is a better predictor of mortality than BMI, and MTCSA had a strong impact on mortality in patients with an FEV(1) < 50% predicted.
New England Journal of MedicineEffect of Inhaled Triamcinolone on the Decline in Pulmonary Function in Chronic Obstructive Pulmonary Disease
818 Citations2000The Lung Health Study Research Group
Inhaled triamcinolone does not slow the rate of decline in lung function in people with COPD, but it improves airway reactivity and respiratory symptoms and decreases the use of health care services for respiratory problems.
American Journal of Respiratory and Critical Care MedicinePeripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease
812 Citations1998Sarah Bernard, Pierre Leblanc +5 more
In COPD, the distribution of peripheral muscle weakness and the correlation between quadriceps strength and the degree of airflow obstruction suggests that chronic inactivity and muscle deconditioning are important factors in the loss in muscle mass and strength.
The LancetLong-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial
808 Citations1999Jørgen Vestbo, Torben Søorensen +4 more
Inhaled budesonide was of no clinical benefit in COPD patients recruited from the general population by screening and the role of long-term inhaled corticosteroids in the treatment of mild to moderate COPD is questioned.
American Journal of Respiratory and Critical Care MedicineCD8+ T-Lymphocytes in Peripheral Airways of Smokers with Chronic Obstructive Pulmonary Disease
791 Citations1998Marina Saetta, Antonino Di Stefano +7 more
It is concluded that smokers who develop symptoms of chronic bronchitis and chronic airflow limitation have an increased number of CD8+ T-lymphocytes and an increased smooth muscle area in the peripheral airways as compared with asymptomatic smokers with normal lung function, supporting the important role of CD4+ and CD8+, as well as airway remodeling in the pathogenesis of chronic obstructive pulmonary disease.
American Review of Respiratory DiseasePrognosis in Chronic Obstructive Pulmonary Disease
786 Citations1986N. R. Anthonisen, E C Wright +2 more
Patients with low initial values of FEV1 showed relatively little further decline, probably indicating a survivor effect, and mortality in the present series was less than that of a previous series, and the same as that of hypoxemic patients with COPD who received continuous home O2 therapy.
American Journal of Respiratory and Critical Care MedicineSystemic Oxidative Stress in Asthma, COPD, and Smokers
780 Citations1996Irfan Rahman, Deborah Morrison +2 more
Smoking, acute exacerbations of COPD, and asthma are associated with a marked oxidant/ant antioxidant imbalance in the blood, associated with evidence of increased oxidative stress, and the decreased antioxidant capacity in plasma may result from different mechanisms in these conditions.
American Journal of Respiratory and Critical Care MedicineAssociation of Chronic Mucus Hypersecretion With FEV1 Decline and Chronic Obstructive Pulmonary Disease Morbidity. Copenhagen City Heart Study Group
754 Citations1996Jørgen Vestbo, Eva Prescott +1 more
Chronic mucus hypersecretion was significantly and consistently associated with both an excess FEV1 decline and an increased risk of subsequent hospitalization because of COPD.
American Journal of Respiratory and Critical Care MedicineEffect of Pharmacotherapy on Rate of Decline of Lung Function in Chronic Obstructive Pulmonary Disease: Results from the TORCH Study
746 Citations2008Bartolomé R. Celli, Nicola E. Thomas +8 more
Pharmacotherapy with salmeterol plus fluticasone propionate, or the components, reduces the rate of decline of FEV(1) in patients with moderate-to-severe COPD, thus slowing disease progression.
European Respiratory JournalMaintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease
738 Citations2003Peter M.A. Calverley, Watchara Boonsawat +4 more
Budesonide/formoterol in a single inhaler maintains the benefit of treatment optimisation, stabilising lung function and delaying exacerbations more effectively than either component drug alone or placebo.
European Respiratory JournalImproved health outcomes in patients with COPD during 1 yr's treatment with tiotropium
736 Citations2002Walter Vincken, J.A. van Noord +5 more
Tiotropium was effective in improving dyspnoea, exacerbations, health-related quality of life and lung function in patients with chronic obstructive pulmonary disease, and exceeds the benefits seen with ipratropium.
American Journal of Respiratory and Critical Care MedicineSmoking Cessation and Lung Function in Mild-to-Moderate Chronic Obstructive Pulmonary Disease: The Lung Health Study
735 Citations2000Paul D. Scanlon, John E. Connett +4 more
Smokers with airflow obstruction benefit from quitting despite previous heavy smoking, advanced age, poor baseline lung function, or airway hyperresponsiveness, and Predictors of change in lung function included responsiveness to beta-agonist, baseline FEV, methacholine reactivity, age, sex, race, and baseline smoking rate.
ThoraxRelation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations
728 Citations2000Angshu Bhowmik
Patients with more frequent exacerbations have higher baseline sputum cytokine levels, which may predict the frequency of future exacerbations.
American Review of Respiratory DiseasePrevalence and Characteristics of Nutritional Depletion in Patients with Stable COPD Eligible for Pulmonary Rehabilitation
725 Citations1993Annemie M.W.J. Schols, Peter B. Soeters +4 more
It is concluded that fat-free mass is a better indicator of body mass depletion than body weight.
ThoraxRelationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
690 Citations2002Irem Patel
Lower airway bacterial colonisation in the stable state modulates the character and frequency of COPD exacerbations.
Annals of Internal MedicineNoninvasive Mechanical Ventilation in the Weaning of Patients with Respiratory Failure Due to Chronic Obstructive Pulmonary Disease
669 Citations1998Stefano Nava, Nicolino Ambrosino +7 more
The aim of this multicenter, randomized study was to evaluate the effectiveness of a new weaning approach in patients with chronic obstructive pulmonary disease, which consisted of 24 to 48 hours of traditional ventilation delivered through an endotracheal tube followed by noninvasive pressure support ventilation.
PubMedTiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.
654 Citations2007Shawn D. Aaron, Katherine L. Vandemheen +30 more
A randomized, double-blind, placebo-controlled clinical trial to determine whether combining tiotropium with salmeterol or fluticasonesalmeterol produces greater improvements in clinical outcomes for adults with moderate or severe COPD compared with tiotopium therapy alone.
Nature GeneticsGenome-wide association study identifies five loci associated with lung function
598 Citations2009Emmanouela Repapi, The NSHD Respiratory Study Team +93 more
Clinical Microbiology ReviewsBacterial Infection in Chronic Obstructive Pulmonary Disease in 2000: a State-of-the-Art Review
594 Citations2001Sanjay Sethi, Timothy F. Murphy
Recent progress in studies of the molecular mechanisms of pathogenesis of infection in the human respiratory tract and in vaccine development guided by such studies promises to lead to novel ways to treat and prevent bacterial infections in COPD.
American Journal of Respiratory and Critical Care MedicineLower Respiratory Illnesses Promote FEV1 Decline in Current Smokers But Not Ex-Smokers with Mild Chronic Obstructive Pulmonary Disease
591 Citations2001Richard E. Kanner, Nicholas R. Anthonisen +1 more
Smoking and LRI had an interactive effect on FEV(1) in people with mild COPD, and in smokers frequent LRI may influence the long-term course of the disease.
JAMAHospital and 1-Year Survival of Patients Admitted to Intensive Care Units With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
588 Citations1995Michael G. Seneff
Patients with COPD admitted to an ICU for an acute exacerbation have a substantial hospital mortality and severity of the underlying respiratory function substantially influences mortality following hospital discharge, and Physicians should be aware of these relationships when making treatment decisions or evaluating new therapies.
American Review of Respiratory DiseaseBacterial Infection in Chronic Obstructive Pulmonary Disease
584 Citations1992Timothy F. Murphy, Sanjay Sethi
American Review of Respiratory DiseaseSmall Airways Dimensions in Asthma and in Chronic Obstructive Pulmonary Disease
584 Citations1993Kazuyoshi Kuwano, Carol H. Bosken +4 more
The adventitial, submucosal, and muscle area of the asthmatic airways were greater than those of COPD and control, and the muscle area was greater in COPD than in control lungs (p < 0.05).
American Journal of Respiratory and Critical Care MedicineOxidative Capacity of the Skeletal Muscle and Lactic Acid Kinetics During Exercise in Normal Subjects and in Patients With COPD
574 Citations1996François Maltais, A A Simard +4 more
American Journal of Respiratory and Critical Care MedicineBacterial Infection in Chronic Obstructive Pulmonary Disease. A Study of Stable and Exacerbated Outpatients Using the Protected Specimen Brush
563 Citations1995Eduard Monsó, Joseph Ruiz +5 more
The lower airways of asymptomatic chronic obstructive pulmonary disease (COPD) patients can be colonized by bacteria, mainly Haemophilus influenza, Streptococcus pneumoniae, and Moraxella catarrhalis, but the role of lower airway bacteria in stable and exacerbated COPD has not been well defined.
American Journal of Respiratory and Critical Care MedicineEffects of Inhaled and Oral Glucocorticoids on Inflammatory Indices in Asthma and COPD
561 Citations1997Vera M. Keatings, Anon Jatakanon +2 more
The clinical impression that inhaled steroids have little antiinflammatory effect is confirmed, at least in the short term in this group of patients, and suggests that the inflammatory process in COPD is resistant to the anti inflammatory effect of glucocorticoids.
American Journal of Respiratory and Critical Care MedicineCellular and Structural Bases of Chronic Obstructive Pulmonary Disease
557 Citations2001Marina Saetta, Graziella Turato +3 more
American Journal of Respiratory and Critical Care MedicineExhaled 8-Isoprostane as an <i>In Vivo</i> Biomarker of Lung Oxidative Stress in Patients with COPD and Healthy Smokers
547 Citations2000Paolo Montuschi, John V. Collins +5 more
It is shown that free radical production is increased in patients with COPD and that smoking causes an acute increase in oxidative stress, as reflected by 8-isoprostane concentrations in breath condensate.
American Journal of Respiratory and Critical Care MedicineMeasurement of Symptoms, Lung Hyperinflation, and Endurance during Exercise in Chronic Obstructive Pulmonary Disease
533 Citations1998Denis E. O’Donnell, Miu Lam +1 more
It is concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD.
ThoraxEvidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.
524 Citations1996Annemie Schols, Wim A. Buurman +3 more
A subset of patients with COPD with an increased REE and decreased FFM have increased levels of acute phase reactant proteins and inflammatory cytokines in their serum; these phenomena may be causally related.
CHEST JournalEfficacy of Salmeterol Xinafoate in the Treatment of COPD
517 Citations1999Donald A. Mahler, James F. Donohue +8 more
These collective data support the use of salmeterol as first-line bronchodilator therapy for the long-term treatment of airflow obstruction in patients with COPD.
American Review of Respiratory DiseaseBody Weight in Chronic Obstructive Pulmonary Disease: The National Institutes of Health Intermittent Positive-Pressure Breathing Trial
514 Citations1989David O. Wilson, R. M. Rogers +2 more
The hypothesis that factors related to nutritional status are an independent influence on the course of COPD is supported, as body weight was a powerful predictor of diffusing capacity in patients with the same FEV1.
American Journal of Respiratory and Critical Care MedicineIncreased Exhalation of Hydrogen Peroxide in Patients With Stable and Unstable Chronic Obstructive Pulmonary Disease
509 Citations1996P. N. Richard Dekhuijzen, Katja K.H. Aben +5 more
It is demonstrated that patients with stable COPD exhibit increased oxidant production in the airways and that oxidantProduction increases further during exacerbations.
The LancetMulticentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease
509 Citations1998Pier Luigi Paggiaro, Ragnar Dahle +4 more
Fluticasone propionate may be of clinical benefit in patients with COPD over at least 6 months, and may have an important role in the long-term treatment of COPD.
ThoraxPrognostic value of pulmonary artery pressure in chronic obstructive pulmonary disease.
508 Citations1981E Weitzenblum, C. Hirth +4 more
The results emphasise the high prognostic value of PAP since survival rates after four and seven years were significantly lower in the subgroup with PAP greater than 20 mmHg (2.7 kPa).
Archivum Immunologiae et Therapiae ExperimentalisNew developments in the use of citation analysis in research evaluation
502 Citations2009Henk F. Moed
An overview of research assessment methodologies developed in the field of evaluative bibliometrics, a subfield of quantitative science and technology studies, aimed to construct indicators of research performance from a quantitative statistical analysis of scientific-scholarly documents is presented.
American Journal of Respiratory and Critical Care MedicineQuality of Life Changes in COPD Patients Treated With Salmeterol
494 Citations1997Peter M. Jones, T K Bosh
It is shown that a modest change in lung function may be associated with clinically significant gain in health and well-being in COPD patients.
JAMAAntibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis
490 Citations1995Sanjay Saint
Archives of Internal MedicineLife Quality of Patients With Chronic Obstructive Pulmonary Disease
487 Citations1982A. John McSweeny
The life quality of patients with COPD was found to be impaired relative to healthy subjects on all dimensions; depression was the preponderant emotional disturbance reported; difficulties with home management and reduction in social interaction were the primary social-role deficits.
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