Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance
Annual Review of PsychologyPublished 1 February 2002
Michael Rutter, Judy L. Silberg
Citations461
SJR quartileQ1
SJR score13.79
SNIP13.63
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Abstract
The conceptual and methodological issues involved in the study of gene-environment correlations (rGE) and interactions (GxE) are discussed in historical context. Quantitative genetic findings are considered with respect to rGE and GxE in relation to emotional and behavioral disturbance. Key conceptual and substantive implications are outlined in relation to both genetic and environmental risk mediation, with a brief note on evolutionary considerations.
Keywords
PsychologyBiochemistry, Genetics and Molecular Biology
Child DevelopmentHow People Make Their Own Environments: A Theory of Genotype Environment Effects
2,807 Citations1983Sandra Scarr, Kathleen McCartney
A theory of development in which experience is directed by genotypes is proposed, which adapts the 3 kinds of genotype-environment correlations proposed by Plomin, DeFries, and Loehlin in a developmental model used to explain results from studies of deprivation, intervention, twins, and families.
SciencePharmacogenomics: Translating Functional Genomics into Rational Therapeutics
2,486 Citations1999William E. Evans, Mary V. Relling
Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.
American Journal of PsychiatryCausal Relationship Between Stressful Life Events and the Onset of Major Depression
2,450 Citations1999Kenneth S. Kendler, Laura M. Karkowski +1 more
Stressed life events have a substantial causal relationship with the onset of episodes of major depression, however, about one-third of the association between stressful life events and onsets of depression is noncausal, since individuals predisposed to major depression select themselves into high-risk environments.
Psychological ReviewA reinterpretation of the direction of effects in studies of socialization.
1,872 Citations1968Richard Q. Bell
Behavioral and Brain SciencesWhy are children in the same family so different from one another?
1,358 Citations1987Robert Plomin, Denise Daniels
American Journal of PsychiatryStressful life events, genetic liability, and onset of an episode of major depression in women
1,057 Citations1995Kenneth S. Kendler, Ronald C. Kessler +5 more
Biometrical Genetics
958 Citations1982Kenneth Mather, John L. Jinks
CERN Document Server (European Organization for Nuclear Research)The extended phenotype : the gene as the unit of selection
938 Citations1983Richard Dawkins
This sequel to The Selfish Gene argues that since genes can be said to have extended phenotypes outside the body in which they sit, the authors will have to revolutionize their views of evolutionary adaptation.
The LancetAssociation of apolipoprotein E polymorphism with outcome after head injury
702 Citations1997Graham M. Teasdale, James A. R. Nicoll +2 more
A significant genetic association of APOE polymorphism with outcome after head injury is shown supporting the hypothesis of a genetically determined influence.
Behavior GeneticsMultiple regression analysis of twin data
665 Citations1985J. C. DeFries, David W. Fulker
A multiple regression model for the analysis of twin data is described in which a cotwin's score is predicted from a proband's score and the coefficient of relationship, which provides a powerful test of the extent to which the difference between the mean for probands and that for the unselected population is heritable.
International Journal of Developmental NeuroscienceDo early‐life events permanently alter behavioral and hormonal responses to stressors?
650 Citations1998Hymie Anisman, Marilee D. Zaharia +2 more
It is suggested that genetic factors may influence dam–pup interactive styles and may thus proactively influence the response to subsequent stressors among vulnerable animals, in contrast, in relatively hardy animals the early‐life manipulations may have less obvious effects.
Psychological MedicinePubertal changes in hormone levels and depression in girls
606 Citations1999Adrian Angold, E. Jane Costello +2 more
These findings argue against theories that explain the emergence of the female excess of depression in adulthood in terms of changes in body morphology and their resultant psychosocial effects on social interactions and self-perception and suggest that causal explanations of the increase in depression in females need to focus on factors associated with changes in androgen and oestrogen levels.
Annual Review of ImmunologyTHE IMMUNOGENETICS OF HUMAN INFECTIOUS DISEASES
594 Citations1998Adrian V. S. Hill
It is likely that susceptibility to most microorganisms is determined by a large number of polymorphic genes, and identification of these should provide insights into protective and pathogenic mechanisms in infectious diseases.
NeurologySynergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease
585 Citations1995Richard Mayeux, Ruth Ottman +7 more
Cambridge University Press eBooksResilience Reconsidered: Conceptual Considerations, Empirical Findings, and Policy Implications
583 Citations2000Michael Rutter
Behavioral and Brain SciencesThe nature of nurture: Genetic influence on “environmental” measures
567 Citations1991Robert Plomin, C. S. Bergeman
Evidence for genetic influence on environmental measures will emerge in quantitative genetic analyses if genetically influenced characteristics of individuals are assessed by these environmental measures, which has far-reaching implications for the behavioral and brain sciences.
American Journal of PsychiatryModels for the joint effect of genotype and environment on liability to psychiatric illness
546 Citations1986Kenneth S. Kendler, Lindon J. Eaves
The authors attempt to demonstrate that genes and the environment can interact in several interesting and potentially subtle ways, that these interactions can be expressed in simple models from which clear empirical predictions can be generated, and that elucidation of the etiology of psychiatric disorders will require the consideration of both genetic and environmental risk factors.
Archives of General PsychiatryGenetic-Environmental Interaction in the Genesis of Aggressivity and Conduct Disorders
526 Citations1995Remi J. Cadoret
Environmental effects and genetic-environmental interaction account for significant variability in adoptee aggressivity, conduct disorder, and adult antisocial behavior and have important implications for the prevention and intervention of conduct disorder and associated conditions such as substance abuse and aggressivity.
Nature GeneticsA polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria
492 Citations1999Julian C. Knight, Irina A. Udalova +5 more
The OCT-1-binding genotype, found in approximately 5% of Africans, is associated with fourfold increased susceptibility to cerebral malaria in large case-control studies of West African and East African populations, after correction for other known TNF polymorphisms and linked HLA alleles.
Behavioral and Brain SciencesInsensitivity of the analysis of variance to heredity-environment interaction
477 Citations1990Douglas Wahłsten
If the goal of partitioning variance among mutually exclusive causes and calculating “heritability” coefficients is abandoned, interactive relationships can be examined more seriously and can enhance the understanding of the ways living things develop.
Nature Reviews GeneticsQuantitative trait loci in Drosophila
420 Citations2001Trudy F. C. Mackay
Drosophila quantitative trait loci have sex-, environment- and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes, and offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.
Development and PsychopathologyIntegrating nature and nurture: Implications of person–environment correlations and interactions for developmental psychopathology
412 Citations1997Michael Rutter, Judy Dunn +7 more
The developmental interplay between nature and nurture and person-environment interplay are discussed, with particular reference to implications for research in developmental psychopathology.
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403 Citations1999David Rowe, Kristen C. Jacobson +1 more
How parental education level moderates the genetic and environmental contributions to variation in verbal IQ is examined in 1909 non-Hispanic Whites and African American sibling pairs from the National Longitudinal Study of Adolescent Health.
Archives of General PsychiatryThe Influence of Genetic Factors and Life Stress on Depression Among Adolescent Girls
400 Citations1999Judy L. Silberg, Andrew Pickles +8 more
The greater heritability for depression in pubertal girls, its genetic mediation over time, and the increase in genetic variance for life events may be one possible explanation for the emergence of increased depression among puberal girls and its persistence through adolescence.
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361 Citations2000Kristine Yaffe, Mary N. Haan +3 more
Estrogen use was associated with less cognitive decline among ε4-negative women but not ε 4-positive women, and potential mechanisms, including carotid atherosclerosis, by which ε3 may interact with estrogen and cognition warrant further investigation.
Cambridge University Press eBooksNature and Nurture during Infancy and Early Childhood
344 Citations1988Robert Plomin, John C. DeFries +1 more
Psychological MedicineStressful life events and genetic liability to major depression: genetic control of exposure to the environment?
340 Citations1997Kenneth S. Kendler, Laura Karkowski-Shuman
In women, genetic risk factors for MD increase the probability of experiencing SLEs in the interpersonal and occupational/financial domains, and the genetic liability to alcoholism impacted on the risk for being robbed and having trouble with the law.
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334 Citations2001Kenneth S. Kendler, C Gardner +2 more
Using broad but not narrower definitions of illness, genetic factors play a greater role in the aetiology of MD in women than in men, raising the possibility that the impact of some loci on risk for MD will differ in men and women.
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The findings showed that most of the association between negative parenting and children's externalizing behavior was not explicable on the basis of an evocative gene-environment correlation and that an additional environmentally mediated parental effect on children's behavior was plausible.
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324 Citations1992Matt McGue, David T. Lykken
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319 Citations1996Ruth Ottman
This overview presents a simple definition of gene-environment interaction and suggests study designs for detecting it, and five biologically plausible models are described for the relations between genotypes and environmental exposures, in terms of their effects on disease risk.
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The results suggest that stressful life events reflect more than random influences, which suggest that personal and social factors that predispose to life events are substantially influenced by an individual's genetic and family background.
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308 Citations1974Raymond R. Crowe
The findings point to the importance of interactions between genetic and environmental factors in the development of antisocial personality.
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306 Citations2000Michael Rutter
Challenges for the future include greater use of research strategies to provide rigorous tests of causal hypotheses, improved measures of psychosocial risks that can be applied to large samples, and understanding of individual differences in susceptibility.
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304 Citations2000
Theoretical Population BiologyModels for cultural inheritance I. Group mean and within group variation
297 Citations1973L. L. Cavalli‐Sforza, Marcus W. Feldman
It has been demonstrated that, if g is different from zero and positive, however small, in spite of new variation arising at every generation the variation of the trait within the group will stabilize at a finite level.
Development and PsychopathologyPartners, peers, and pathways: Assortative pairing and continuities in conduct disorder
297 Citations1993David Quinton, Andrew Pickles +2 more
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291 Citations2001Judy L. Silberg, Michael Rutter +2 more
There is an environmentally mediated effect of life events on depression/anxiety, and genetic factors play a significant role in individual differences in susceptibility to these environmentally mediated risks.
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Individual variation in response to drugs is a substantial clinical problem and it is estimated that 106 000 patients die and 2.2 million are injured each year by adverse reactions to prescribed drugs.
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281 Citations2001Paul K. Maciejewski, Holly G. Prigerson +1 more
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258 Citations1995David Reiss
Parenting behavior directed specifically at each child in the family is a major correlate of symptoms in adolescents, and harsh parental behavior directed at a sibling may have protective effects for adolescents, a phenomenon the "siblin barricade".
British Journal of Mathematical and Statistical PsychologyA progressive approach to non‐additivity and genotype‐environmental covariance in the analysis of human differences
256 Citations1977L J Eaves, Krystyna Last +2 more
A comprehensive framework of theory and method is outlined in which various typos of non-additivity and non-independence of gene and environmental action and interaction—genotype—environment interaction and covariation, dominance and assortative mating can be critically assessed.
The LancetApolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study
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Smoking increases the risk of coronary heart disease in men of all genotypes but particularly in men carrying the epsilon4 allele, which is independent of other classic risk factors.
Trends in GeneticsHuman morbid genetics revisited: relevance of epigenetics
250 Citations2001Artūras Petronis
It is argued in this article that epigenetic misregulation of genes is more consistent with the features of complex diseases than is DNA sequence variation, and therefore epigenetic factors could be important in understanding the origins ofcomplex diseases.
Journal of Studies on AlcoholGenetic and environmental factors in alcohol abuse and antisocial personality.
230 Citations1987Remi J. Cadoret, Ed Troughton +1 more
The present study examines an independently collected sample of adoptees from a different agency--the Iowa Children's and Family Services, and confirms the multifactorial model for adoptee alcohol abuse that was previously found in the Lutheran Social Service data.
American Journal of Public HealthRelative effect of genetic and environmental factors on body height: differences across birth cohorts among Finnish men and women
227 Citations2000Karri Silventoinen, Jaakko Kaprio +2 more
Heritability of height increased across Finnish birth cohorts born in the first half of this century and leveled off after World War II; environmental factors appear to be more important among women than men.
Arteriosclerosis Thrombosis and Vascular BiologyApoE Polymorphism and Fish Oil Supplementation in Subjects With an Atherogenic Lipoprotein Phenotype
218 Citations2000Anne Marie Minihane, Syrah Khan +6 more
The data demonstrate the efficacy of fish oil fatty acids in counteracting the proatherogenic lipid profile of the ALP but also that the apoE genotype influences responsiveness to this dietary treatment.
Archives of General PsychiatryTobacco Consumption in Swedish Twins Reared Apart and Reared Together
213 Citations2000Kenneth S. Kendler, Laura M. Thornton +1 more
In women, the impact of genetic factors increased in more recent cohorts, suggesting that, as social restrictions on female tobacco use relaxed over time, heritable influences increased in importance.
Journal of Studies on AlcoholInteractive effects of genotype and social environment on alcohol consumption in female twins.
207 Citations1989Andrew C. Heath, R Jardine +1 more
In the young sample (average age 35 years), there is no evidence that individuals genetically predisposed to heavy drinking are any less likely to be married than the rest of the population, and statistical analyses show that marital status is an important modifier of genetic effects on drinking habits.
Medical Entomology and Zoology'LIFELINES: BIOLOGY, FREEDOM, DETERMINISM '
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Biology, freedom, determinism observing and interventing knowing what the authors know the triumph of reductionism, making biology whole again.
PubMedMultifactorial inheritance with cultural transmission and assortative mating. I. Description and basic properties of the unitary models.
184 Citations1978John P. Rice, C. Robert Cloninger +1 more
A new model, termed the unitary model, is introduced, which includes these models and is appropriate when combined genetic and cultural transmission is present and when data are available only for individuals reared in intact nuclear families.
Developmental PsychologyGenetic and environmental influences on parent-son relationships: Evidence for increasing genetic influence during adolescence.
183 Citations1997Irene J. Elkins, Matt McGue +1 more
NatureThe rise of neurogenetic determinism
180 Citations1995S Rose
Dramatic advances in neuroscience are changing and enriching the understanding of brain and behaviour, but reductionist interpretations of these advances can cause great harm.
Behavior GeneticsThe Influence of Religion on Alcohol Use Initiation: Evidence for Genotype X Environment Interaction
180 Citations1999Judith R. Koopmans, Wendy S. Slutske +2 more
Higher heritabilities for females without areligious upbringing compared to females with a religious upbringing were found, and the relative magnitude of the genetic influences on the risk of alcohol use initiation would be greater for those adolescents and young adults who were raised in a less religious environment.
Behavior GeneticsA third source of developmental differences
171 Citations1993Peter C. M. Molenaar, Dorret I. Boomsma +1 more
An illustrative list is presented of human and animal studies which each point to the existence of a third source, in addition to genetic and environmental factors, underlying phenotypic differences in development.
HeredityA model for sibling effects in man
170 Citations1976Lindon J. Eaves
A model is developed to specify the environmental effect of one sibling on another for a polygenic trait that is detectable in principle and the approach is illustrated with twin data relating to psychoticism.
Archives of General PsychiatrySex Differences in Predictors of Antisocial Behavior in Adoptees
157 Citations1980Remi J. Cadoret
Boys are more vulnerable than girls to the adverse effects of a psychiatrically ill adoptive family member or divorce in the adoptive parents and the genetic variables that predict antisocial behavior are having an antisocial or alcoholic biologic relative.
Psychological MedicineChildhood parental loss and alcoholism in women: a causal analysis using a twin-family design
152 Citations1996Kenneth S. Kendler, Michael C. Neale +5 more
Childhood parental loss is probably a direct and significant environmental risk factor for the development of alcoholism in women, and a significant proportion of the association is due to non-causal genetic mechanisms.
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Differential environmental experiences of MZ and DZ twins in childhood and adolescence are unlikely to represent a substantial bias in twin studies of most major psychiatric and substance dependence disorders but may influence twin similarity for the initiation of substance use.
Twin ResearchA religious upbringing reduces the influence of genetic factors on disinhibition: Evidence for interaction between genotype and environment on personality
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The British Journal of PsychiatryOpportunities for psychiatry from genetic findings
145 Citations1997Michael Rutter, Robert Plomin
Advances in genetics will make a major impact on clinical psychiatry, and should bring practical benefits for both prevention and treatment.
Journal of Substance AbuseGenetic contribution to risk of smoking initiation: Comparisons across birth cohorts and across cultures
142 Citations1993Andrew C. Heath, Randall Cates +5 more
Self-report data on smoking initiation (whether the respondent admitted ever having smoked) were obtained from three large adult twin samples and found no evidence for cohort differences in genetic and environmental effects (no Genotype x Cohort interaction).
Journal of Personality and Social PsychologyCan personality explain genetic influences on life events?
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Multivariate analyses of personality and life events suggest that all of the genetic variance on controllable, desirable, and undesirable life events for women is common to personality.
Behavior GeneticsA model system for analysis of family resemblance in extended kinships of twins
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Developmental PsychologyRelationships between parenting and adolescent adjustment over time: Genetic and environmental contributions.
136 Citations1999Jenae M. Neiderhiser, David Reiss +2 more
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It is likely that biological and psychological characteristics that are partly under genetic control significantly influence the age at which a person commences sexual activity.
Advances in Behaviour Research and TherapyA genotype-environmental model for psychoticism
131 Citations1977Lindon J. Eaves, H. J. Eysenck
Journal of Child Psychology and PsychiatryGenetic and environmental risk factors in adolescent substance use
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The patterns of correlations across the two waves of the study were consistent with conduct disturbance leading to substance use in both males and females, but depression leading to smoking, drug use and, to a lesser extent, alcohol use in girls.
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Model-fitting analyses indicate that human parental behavior is under significant genetic influence, and suggests that this influence is sex limited, with a higher heritability in mothers than in fathers and that it may result partly from the expression of dominant genes.
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The key finding was that emotional or behavioural disturbance in childhood was associated with a marked increase in the rate of severely negative events and difficulties some two decades later, and this increase was only obtained for stressors with severe negative impact.
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It is concluded that there is true environmental mediation from family maladaptation, operating as a shared effect, which accounts for 3·5% of the phenotypic variance.
Genetic EpidemiologyThe resolution of genotype × environment interaction in segregation analysis of nuclear families
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A model is presented for the effects of one or two loci, a measured index of the environment and genotype × environment and G×E interaction of risk for a discontinuous trait, and it is shown that the parameters could be estimated with acceptable precision and that theeffects of genes, environment, and G–E interaction could be resolved in the simulated populations.
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