Development of renal function in the fetus: a review
Reproduction Fertility and DevelopmentPublished 1 June 1995
Eugenie R. Lumbers
Citations31
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SJR score0.33
SNIP0.66
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TL;DR
This review concentrated mainly on studies of intrauterine renal function carried out in chronically-catheterized fetal sheep, finding that studies in the rat and neonatal puppy provide insight into the functional development of the kidney.
Abstract
This review concentrated mainly on studies of intrauterine renal function carried out in chronically-catheterized fetal sheep. In sheep, as in primates, nephrogenesis is complete before birth. Studies in the rat and neonatal puppy provide insight into the functional development of the kidney, because these species are immature at birth and there is considerable postnatal renal development. Studies of the ovine fetus provide insight into the physiological role(s) of the kidneys during intrauterine life, albeit modified by changes related to maturation.
Keywords
Medicine
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27 Citations1995Kathleen M. Stevenson, Eugenie R. Lumbers
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24 Citations1990Warwick P. Anderson, Kate M. Denton +2 more
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22 Citations1988G D Olsen, Karen M. Sommer +4 more
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22 Citations1993Gibson Kj, Eugenie R. Lumbers
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22 Citations1985Harriet S. Iwamoto, William Oh +1 more
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21 Citations1994Robert A. Brace, Mary E. Wlodek +2 more
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14 Citations1979Hazel H. Szeto, Robert F. Kaiko +4 more
A pharmacokinetic model is supported that describes the disposition of meperidine in the maternal-fetal unit by use of a two-compartment open model with elimination from both maternal and fetal compartments and shows that the drug can diffuse across the placental membranes from the mother into these fluids.
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13 Citations1992Linda K. Kullama, Michael Ross +4 more
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13 Citations1994Megan L. Cock, Mary E. Wlodek +3 more
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12 Citations1989Kenneth T. Nakamura, J. M. Klinkefus +3 more
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PubMedChanges in renal function following delivery of the lamb by caesarean section.
11 Citations1988Smith Fg, Eugenie R. Lumbers
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PubMedThe influence of endogenous mineralocorticoids on the composition of fetal urine.
11 Citations1990Kristina Kairaitis, Eugenie R. Lumbers
In chronically catheterised fetal sheep, endogenous mineralocorticoid activity altered urinary potassium excretion and the urinary Na/K ratio, however this activity was low, as distal blockade with amiloride further decreased the fractional excretion of potassium and increased the urinaryNa/K ratios.
Pediatric ResearchChanges in Renal Function and Blood Volume in the Newborn Lamb Delivered by Cesarean Section
7 Citations1994Karen J. Gibson, Eugenie R. Lumbers
The extent of the natriuresis did not depend on the lamb's initial BV per kg at birth, and the amount of fluid excreted and the clearance of sodium during a 45–min period within the first 1–1.25 h after birth were pproximately equal to the fall in BV that occurred after delivery.
Clinical ScienceCirculating Angiotensin II and Renal Sodium Handling in Man: A Dose-Response Study
7 Citations1993Abdul Rahman, Jayashree Motwani +2 more
Unlike antidiuresis, antinatriuresis after graded doses of angiotensin II in human subjects showed a flat dose-response curve beyond 5 ng min-1 kg-1.
PubMedChanges in fetal and maternal plasma protein concentration and colloid osmotic pressure with gestation.
6 Citations1991Eugenie R. Lumbers, Moore Rs +2 more
Since maternal COP did not change and fetal COP increased, the net transplacental COP gradient between mother and fetus decreased with increasing age, sofetal plasma protein levels can be used to calculate fetal COP while maternal plasmaprotein levels cannot be usedto calculate maternal COP.
Clinical and Experimental Pharmacology and PhysiologyEFFECTS OF AUTONOMIC BLOCKADE ON THE HYPERTENSIVE RESPONSE OF THE FETUS TO HYPEROSMOLALITY
5 Citations1989N.M. Kingsford, Eugenie R. Lumbers
Infusions of hyperosmotic mannitol to the ewe caused a rise in fetal arterial pressure in 17 chronically catheterized fetal sheep aged 120–140 days, and the fetal heart slowed in 13 out of 17 of these fetuses.
Fundamental and Clinical PharmacologyPLASMA MEMBRANE LIPIDS MODULATE THE RESPONSE TO WATER DEPRIVATION IN RAT KIDNEY
2 Citations1989M Mourelle, José L. Reyes +1 more
It was found that the cholesterol/phospholipid ratio of new‐born membranes was significantly higher than that of membranes from 21‐d‐old and adult rats, which were similar, which paralleled low ability to concentrate urine in the newborn and higher sensitivity of the neonatal kidney to water deprivation.
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2 Citations1995Eugenie R. Lumbers, Rebecca S. Moore +1 more
Since infusion of maternal plasma caused a rise in fetal plasma protein concentrations that was similar to the increase that would occur between 128 and 148 days gestation, it is unlikely that any gestation-dependent increase in proximal fractional sodium reabsorption is due solely to a increase in fetal Plasma protein concentrations and hence oncotic pressure.
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