Catalytic Enantioselective Addition of Nitro Compounds to Imines—A Simple Approach for the Synthesis of Optically Activeβ-Nitro-α-Amino Esters
Angewandte ChemiePublished 17 August 2001
Nagatoshi Nishiwaki, Kristian Rahbek Knudsen, Kurt V. Gothelf, Karl Anker Jørgensen
Citations54
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Abstract
Eine katalytische asymmetrische Nitro-Mannich-Reaktion, die durch chirale Bisoxazolin-Kupfer-Komplexe katalysiert wird [Gl. (1), Pg = Schutzgruppe], liefert β-Nitro-α-aminosäureester mit hervorragenden Diastereo- und Enantioselektivitäten. Die Reaktionen können bei Raumtemperatur und Normaldruck durchgeführt werden.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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