Electrophysiology of Hippocampal Neurons
Cerebral cortexPublished 1 January 1987
Philip A. Schwartzkroin, Alan L. Mueller
Citations299
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TL;DR
There is perhaps more information available today regarding the properties of hippocampal pyramidal cells than of any other CNS cell type except the spinal cord motoneuron.
Abstract
There is perhaps more information available today regarding the properties of hippocampal pyramidal cells than of any other CNS cell type except the spinal cord motoneuron. The hippocampus, with the associated dentate granule cell region, has been studied intensively with electrophysiological techniques. The reasons for such interest and study are several, ranging from the technical accessibility of hippocampal neurons to their hypothesized role in learning and memory (see Isaacson and Pribram, 1975; Swanson et al. 1982; Seifert, 1983).
Keywords
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Brain ResearchThe excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro
243 Citations1981Jane Dodd, Raymond Dingledine +1 more
It is suggested that the slow onset and offset of the responses evoked by ACh are not compatible with models based on diffusion and are best explained by postulating a sequential generation of one or more intermediates.
Journal of NeurophysiologyHippocampal pyramidal cells: significance of dendritic ionic conductances for neuronal function and epileptogenesis
242 Citations1979R. D. Traub, R. Llinás
The model suggests that, for these nerve cells, alterations in specific membrane properties, particularly calcium electroresponsiveness, can lead to bursting behavior that resembles epileptogenic neuronal responses.
Electroencephalography and Clinical NeurophysiologyBasic mechanisms of neuronal hyperexcitability
239 Citations1984John R. Hughes
The Journal of Comparative NeurologyIpsilateral afferents to the commissural zone of the fascia dentata, demonstrated in decommissurated rats by silver impregnation
235 Citations1971Jens Zimmer
An ipsilateral pathway to the commissural zone of the dentate fascia has been demonstrated in the rat using the Fink‐Heimer silver impregnation method and the resulting degeneration was shown to be of purely ipsilaterally origin.
Brain ResearchThe relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation
234 Citations1979Thomas V. Dunwiddie, Gary Lynch
The effect of varying calcium and magnesium concentrations was observed on the development of long-term potentiation in the CA1 region of the rat hippocampus maintained in vitro, suggesting that LTP is unrelated to these short-term forms of plasticity, but is either a calcium-dependent process itself, or is dependent upon some other calcium-related phenomenon.
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