des-Tyr1-γ-Endorphin and haloperidol increase pineal gland melatonin levels in rats
PeptidesPublished 1 May 1983
Odile Gaffori, M. Geffard, Jan M. van Ree
Citations28
SJR quartileQ2
SJR score0.96
SNIP0.82
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TL;DR
The effect of subcutaneously injected DTγE (β-endorphin, (βE)2–17) on the pineal melatonin level was compared with that of closely related peptides and the neuroleptic drug haloperidol to find that it increased the melatonin levels.
Abstract
The effect of subcutaneously injected DT gamma E (beta-endorphin, (beta E)2-17) on the pineal melatonin level was compared with that of closely related peptides and the neuroleptic drug haloperidol. As found previously, DT gamma E (3 ng/rat and 300 ng/rat) increased the melatonin levels. Similar doses of DT alpha E (beta E 2-16), DT beta E (beta E 2-31), gamma E (beta E 1-17), alpha E (beta E 1-16) and beta E failed to significantly change the melatonin levels in both the dark and the light phase. Haloperidol in a dose of 300 ng/rat exhibited a similar effect as DT gamma E.
Keywords
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