Accounting for error due to misclassification of exposures in case–control studies of gene–environment interaction

An estimation strategy is devised that corrects for misclassification errors and also exploits the gene-environment independence assumption and the proposed corrected point estimates and confidence intervals for misclassified data reduce back to standard analytical forms as the mis classification error rates go to zero.

Abstract

We consider analysis of data from an unmatched case-control study design with a binary genetic factor and a binary environmental exposure when both genetic and environmental exposures could be potentially misclassified. We devise an estimation strategy that corrects for misclassification errors and also exploits the gene-environment independence assumption. The proposed corrected point estimates and confidence intervals for misclassified data reduce back to standard analytical forms as the misclassification error rates go to zero. We illustrate the methods by simulating unmatched case-control data sets under varying levels of disease-exposure association and with different degrees of misclassification. A real data set on a case-control study of colorectal cancer where a validation subsample is available for assessing genotyping error is used to illustrate our methods.