SPECT imaging of serotonin2 receptors in depression
Psychiatry Research NeuroimagingPublished 1 December 1992
Hugo D’Haenen, Axel Bossuyt, John Mertens, C. Bossuyt‐Piron, Mireille Gijsemans, Léon Kaufman
Citations121
SJR quartileQ1
SJR score1.19
SNIP0.61
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TL;DR
A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects, which could indicate changes in 5HT2 receptors in major depression.
Abstract
Changes of serotonin2 (5HT2) receptors have been described in depression, and long-term antidepressant treatment has been shown to decrease the number of 5HT2 receptors. In this study, single photon emission computed tomography (SPECT), with 2-123I-ketanserin as a ligand, was used to investigate 5HT2 receptors in vivo in the brain of depressed patients and normal volunteers. A higher uptake of the tracer was observed in the parietal cortex of the patients, and there was a right greater than left asymmetry in the infero-frontal region of the depressed subjects and not in that of the control subjects. These findings could indicate changes in 5HT2 receptors in major depression.
Keywords
MedicineNeuroscience
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