INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS
The LancetPublished 1 January 1983
Michael Stanley, J. John Mann
Citations533
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The combined findings of both studies support the decreased use of serotonin in suicide victims and may also throw light on the mechanism of action of antidepressant drugs.
Abstract
Differences in serotonin-2 (5-HT2) receptor properties were studied in frontal cortex from suicide victims and controls. The number of 5-HT2 receptors was significantly higher (44%) in the suicide group. The postsynaptic receptor changes were consistent with previous findings of a reduced number of presynaptic serotonin receptors in the same post-mortem series. The combined findings of both studies support the decreased use of serotonin in suicide victims and may also throw light on the mechanism of action of antidepressant drugs.
Keywords
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