Reversal by naloxone of adaptation of rats to noxious stimuli
Life SciencesPublished 1 February 1979
Masamichi Satoh, Shin-Ichi Kawajiri, Masaki Yamamoto, Hisako Makino, Hiroshi Takagi
Citations35
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
The bradykinin-induced response was reduced following the repetition of such noxious stimuli in some male Sprague-Dawley rats classified as the noxious-adaptable group, while the reduction of bradykinsin-response did not occur in the majority of the same strain rats in theNoxious-non-adaptability group.
Abstract
Bradykinin, a potent pain-producing substance, injected into the common iliac artery of the rat produced flexor reflexes of the hind-limb. The bradykinin-induced response was reduced following the repetition of such noxious stimuli in some male Sprague-Dawley rats classified as the noxious-adaptable group, while the reduction of bradykinin-response did not occur in the majority of the same strain rats in the noxious-non-adaptable group. Naloxone in doses of 0.1 – 2.0 mg/kg restored the flexor reflexes to the noxious stimulation, in a dose dependent manner, in the former group; ED5 0 value being 0.61 mg/kg. On the other hand, naloxone in doses up to 5.0 mg/kg produced no hyperalgesic effect in the latter group. Thus, genetic variation in endogenous opioid systems has to be considered.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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