Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes
ThoraxPublished 25 May 2007Open access
Sophie West, Debby Nicoll, T. M. Wallace, D.R. Matthews, John Stradling
Citations407
SJR quartileQ1
SJR score2.45
SNIP2.08
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Therapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA.
Abstract
Therapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA.
Keywords
PsychologyMedicineNeuroscience
DiabetologiaHomeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
31,449 Citations1985David R. Matthews, J P Hosker +4 more
The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Kidney & Blood Pressure ResearchMagnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
29,696 Citations2017Ömer Toprak, Hüseyin Kurt +4 more
This guideline contains brief reference to diagnosis and clinical interventions and can serve as a "road map" linking other clinical practice guidelines and pointing out where other guidelines need to be developed.
DiabetesRole of Insulin Resistance in Human Disease
12,152 Citations1988Gerald M. Reaven
The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
New England Journal of MedicineThe Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
10,226 Citations1993Terry Young, Mari Palta +4 more
The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women, and is associated with daytime hypersomnolence.
American Journal of Physiology-Endocrinology and MetabolismGlucose clamp technique: a method for quantifying insulin secretion and resistance.
7,450 Citations1979R. A. DeFronzo, J. D. Tobin +1 more
Methods for the quantification of beta-cell sensitivity to glucose (hyperglycemic clamp technique) and of tissue sensitivity to insulin (euglycemic insulin clamp technique] are described.
The LancetImpact of sleep debt on metabolic and endocrine function
3,657 Citations1999Karine Spiegel, Rachel Leproult +1 more
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
Cardiorenal MedicineThe Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
3,277 Citations2016Fahad Aziz, Kunal Chaudhary
The bidirectional interlink among these apparently different disease processes which share common pathophysiological mechanisms is highlighted and the importance of treating them collectively to improve outcomes is emphasized.
Diabetes CareHomeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.
2,468 Citations2000Enzo Bonora, Giovanni Targher +6 more
The HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity and there is good agreement between the two methods in the categorization of subjects according to insulin sensitivity.
DiabetesU.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease
1,924 Citations1995U.K. Prospective Diabetes Study Group
Sulfonylurea, metformin, and insulin therapies were similarly effective in improving glucose control compared with a policy of diet therapy and whether any specific therapy is advantageous or disadvantageous.
American Journal of Respiratory and Critical Care MedicineObstructive Sleep Apnea Is Independently Associated with Insulin Resistance
1,307 Citations2002Msm Ip, Bing Lam +4 more
The findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration.
The LancetAmbulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial
1,051 Citations2002Justin CT Pepperell, Sharon Ramdassingh-Dow +5 more
In patients with most severe sleep apnoea, nCPAP reduces blood pressure, providing significant vascular risk benefits, and substantially improving excessive daytime sleepiness and quality of life.
American Journal of Respiratory and Critical Care MedicineSleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men
956 Citations2002Naresh M. Punjabi, John D. Sorkin +4 more
Increasing AHI was associated with worsening insulin resistance independent of obesity and Multivariable linear regression analyses revealed that sleep-disordered breathing is a prevalent condition in mildly obese men and is independently associated with glucose intolerance and insulin resistance.
Medical science symposia seriesRole of Insulin Resistance in Human Disease
901 Citations1992Gerald M. Reaven
The LancetComparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial
831 Citations1999Crispin Jenkinson, Robert J. Davies +2 more
The effects of therapeutic NCPAP reduces excessive daytime sleepiness and improves self-reported health status compared with a subtherapeutic control and confirms previous uncontrolled clinical observations and the results of controlled trials that used an oral placebo.
American Journal of Respiratory and Critical Care MedicineIncreased Incidence of Cardiovascular Disease in Middle-aged Men with Obstructive Sleep Apnea: A 7-Year Follow-up
788 Citations2002Yüksel Peker, Jan Hedner +3 more
It is concluded that the risk of developing CVD is increased in middle-aged OSA subjects independently of age, BMI, SBP, diastolic blood pressure, DBP, and smoking.
American Journal of Respiratory and Critical Care MedicineContinuous Positive Airway Pressure Treatment Rapidly Improves Insulin Sensitivity in Patients with Obstructive Sleep Apnea Syndrome
602 Citations2003Igor Alexander Harsch, Simin Pour Schahin +9 more
The improved insulin sensitivity after 2 nights of treatment may reflect a decreasing sympathetic activity, indicating that sleep apnea is an independent risk factor for increased insulin resistance.
DiabetesPlasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
585 Citations2003Otto Tschritter, Andreas Fritsche +8 more
In nondiabetic individuals, high adiponectin predicts increased insulin sensitivity, independent of low body fat mass and affects not only insulin-stimulated glucose disposal but also lipoprotein metabolism and insulin-mediated suppression of postprandial FFA release.
Archives of Internal MedicineType 2 Diabetes, Glycemic Control, and Continuous Positive Airway Pressure in Obstructive Sleep Apnea
457 Citations2005Ambika Babu, James J. Herdegen +3 more
It is suggested that SDB is pathophysiologically related to impaired glucose homeostasis, and that CPAP can be an important therapeutic approach for diabetic patients with SDB.
ThoraxEffect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes
407 Citations2007Sophie West, Debby Nicoll +3 more
Therapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA.
Diabetes CareImproved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone
406 Citations2001Yoshinori Miyazaki, Archana Mahankali +7 more
It is suggested that pioglitazone therapy in type 2 diabetic patients decreases lasting and postprandial plasma glucose levels by improving hepatic and peripheral (muscle) tissue sensitivity to insulin.
The Journal of Clinical Endocrinology & MetabolismObstructive sleep apnea in obese noninsulin-dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin responsiveness.
284 Citations1994Belinda Brooks, Peter A. Cistulli +6 more
The results indicate that OSA occurs commonly in obese NIDDM patients with excessive sleepiness or heavy snoring, and treatment of their OSA may improve insulin responsiveness.
American Journal of Physiology-Endocrinology and MetabolismAbdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus
256 Citations2002Yoshinori Miyazaki, Leonard C. Glass +4 more
It is concluded that visceral adiposity is associated with both peripheral and hepatic insulin resistance, independent of gender, in type 2 diabetes mellitus, in T2DM.
Respiratory Physiology & NeurobiologySleep-disordered breathing, glucose intolerance, and insulin resistance
228 Citations2003Naresh M. Punjabi, Murtuza M. Ahmed +3 more
Current data point to an independent association between SDB and impaired glucose homeostasis, and potential mediators of this association include altered adrenergic function, the direct effects of hypoxemia on glucose regulation, and release of proinflammatory cytokines that affect metabolism.
Journal of Sleep ResearchA behavioural test to assess daytime sleepiness in obstructive sleep apnoea
220 Citations1997L S Bennett, John Stradling +1 more
The ability of a simple test of sustained ‘wakefulness’ to discriminate the excessive somnolence of severe symptomatic obstructive sleep apnoea from normality is assessed, and its results are compared to the traditional EEG based Maintenance of Wakefulness Test (MWT).
RespirationThe Effect of Continuous Positive Airway Pressure Treatment on Insulin Sensitivity in Patients with Obstructive Sleep Apnoea Syndrome and Type 2 Diabetes
220 Citations2004Igor Alexander Harsch, Simin Pour Schahin +7 more
The results indicate that OSA itself is an independent risk factor for insulin resistance, and this effect may be explained by the elevated sympathetic activity in OSA.
American Journal of Respiratory and Critical Care MedicineMeasurement Properties of the Calgary Sleep Apnea Quality of Life Index
159 Citations2002W. Ward Flemons, Marlene Reimer
It is concluded that the SAQLI has excellent measurement properties for an evaluative instrument, and beginning evidence of validity as a discriminative index, and will be an important outcome measure in clinical trials.
Diabetic MedicineAn increase in insulin sensitivity and basal beta‐cell function in diabetic subjects treated with pioglitazone in a placebo‐controlled randomized study
127 Citations2004T. M. Wallace, J Lévy +1 more
To investigate the effect of treatment with pioglitazone on beta‐cell function and insulin sensitivity in Type 2 diabetes, a large number of patients with type 2 diabetes have received treatment with this drug.
Sleep MedicineCPAP treatment does not affect glucose–insulin metabolism in sleep apneic patients
113 Citations2001Marcela Smurra, Pierre Philip +4 more
The data do not support the existence of a significant relationship between glucose and insulin metabolism and obstructive sleep apnea, and obesity, when present, is the important variable.
Diabetes CareAcarbose Improves Glycemic Control in Overweight Type 2 Diabetic Patients Insufficiently Treated With Metformin
84 Citations2003Patrick Phillips, Jeff Karrasch +3 more
The addition of acarbose to meetformin monotherapy provides an efficacious and safe alternative for glycemic improvement in overweight type 2 patients inadequately controlled by metformin alone.
The Tohoku Journal of Experimental MedicinePioglitazone (AD-4833) Ameliorates Insulin Resistance in Patients with NIDDM
81 Citations1997Yoshimitsu Yamasaki, Ryuzo Kawamori +15 more
It is indicated that pioglitazone enhances the insulin action in NIDDM patients on diet alone or SU, and thereby improves both plasma glucose level and lipid profiles.
The Journal of Clinical Endocrinology & MetabolismThe glucose clamp procedure activates the sympathetic nervous system even in the absence of hyperinsulinemia.
30 Citations1995Andreas Moan, Aud Høieggen +4 more
It is concluded that the increase in plasma norepinephrine concentration observed during an euglycemic glucose clamp examination may be attributed to the procedure itself, and that the inclusion of a control group is mandatory when assessing SNS activity.