Abnormally high EEG alpha synchrony during working memory maintenance in twins discordant for schizophrenia
Schizophrenia ResearchPublished 6 June 2008Open access
Peter Bachman, Junghoon Kim, Cindy M. Yee, Sebastian Therman, Marko Manninen, Jouko Lönnqvist
Citations41
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
These findings demonstrate abnormally increased ERD/ERS amplitudes with increasing memory load in patients with schizophrenia and their co-twins, consistent with inefficiency of the neurocognitive mechanisms supporting active maintenance of information across a delay.
Abstract
These findings demonstrate abnormally increased ERD/ERS amplitudes with increasing memory load in patients with schizophrenia and their co-twins, consistent with inefficiency of the neurocognitive mechanisms supporting active maintenance of information across a delay.
Keywords
Neuroscience
Brain Research ReviewsEEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
6,886 Citations1999Wolfgang Klimesch
Brain Research ReviewsEEG alpha oscillations: The inhibition–timing hypothesis
4,039 Citations2006Wolfgang Klimesch, Paul Sauseng +1 more
The general conclusion is that alpha ERS plays an active role for the inhibitory control and timing of cortical processing whereas ERD reflects the gradual release of inhibition associated with the emergence of complex spreading activation processes.
Clinical NeurophysiologyRemoval of eye activity artifacts from visual event-related potentials in normal and clinical subjects
1,353 Citations2000Tzyy‐Ping Jung, Scott Makeig +4 more
Results show that ICA can be used to effectively detect, separate and remove ocular artifacts from even strongly contaminated EEG recordings, and the results compare favorably to those obtained using rejection or regression methods.
Cerebral CortexOscillations in the Alpha Band (9-12 Hz) Increase with Memory Load during Retention in a Short-term Memory Task
1,219 Citations2002Ole Jensen
It is found that the alpha peak systematically increased with the number of items held in working memory and the load dependence and the tight temporal regulation of alpha provide strong evidence that thealpha generating system is directly or indirectly linked to the circuits responsible for working memory.
International Journal of PsychophysiologyEvent-related dynamics of cortical rhythms: frequency-specific features and functional correlates
859 Citations2001Ch. Neuper, G Pfurtscheller
Induced oscillations in the beta band (13-35 Hz, beta ERS) were found in sensorimotor areas after voluntary movement and after somatosensory stimulation, and may be interpreted as a state of 'inhibition' of neural circuitry in the primary motor cortex.
Schizophrenia ResearchPrefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings
682 Citations2003Dara S. Manoach
American Journal of PsychiatryComplexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down
670 Citations2003Joseph H. Callicott, Venkata S. Mattay +4 more
Patients with schizophrenia whose performance on the N-back working memory task is similar to that of healthy comparison subjects use greater prefrontal resources but achieve lower accuracy and that other patients with schizophrenia fail to sustain the prefrontal network that processes the information, achieving even lower accuracy as a result.
Human Brain MappingEEG alpha synchronization and functional coupling during top‐down processing in a working memory task
476 Citations2005Paul Sauseng, Wolfgang Klimesch +4 more
Evidence is provided that during top‐down processing in a working memory task, α power increases at prefrontal but decreases at occipital electrode sites, thereby reaching a state in which α power and frequency become very similar over large distances.
Archives of General PsychiatryThe Genetic Epidemiology of Schizophrenia in a Finnish Twin Cohort
454 Citations1998Tyrone D. Cannon, Jaakko Kaprio +3 more
In a population-based twin study of schizophrenia, heritability was estimated at 83%, with the remaining variance in liability attributed to environmental factors not shared in common among co-twins.
Biological PsychiatrySpatial working memory as an endophenotype for schizophrenia
284 Citations2003David C. Glahn, Sebastian Therman +5 more
The findings suggest that deficits in the encoding or storage aspects of short-term spatial mnemonic processing may be an effective endophenotypic marker for schizophrenia.
Journal of Abnormal PsychologySchizophrenic performance when distractors are present: Attentional deficit or differential task difficulty?
246 Citations1975Thomas F. Oltmanns, John M. Neale
The finding that the decrement in schizophrenic performance is significantly greater in the distractor condition is significant and may be central to the understanding of the disorder.
Schizophrenia ResearchThe relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects
128 Citations2006Katherine H. Karlsgodt, David C. Glahn +8 more
FMRI activation and performance analysis offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable and supports the idea that both hyper and hypoactivation may be possible along a continuum of behavioral performance in a way consistent with a neural inefficiency model.
Journal of Cognitive NeuroscienceDelay-period Activity in the Prefrontal Cortex: One Function Is Sensory Gating
102 Citations2005Bradley R. Postle
Results are consistent with the view that processes related to sensory gating account for a portion of the delay-period activity that is routinely observed in the dlPFC.
Electroencephalography and Clinical NeurophysiologyMEG-compatible multichannel EEG electrode array
67 Citations1996Juha Virtanen, Teemu Rinne +2 more
An EEG electrode array is described, which is designed to facilitate simultaneous multichannel EEG and MEG recordings and allows shorter preparation times and more reliable contacts than commercially available solutions.
Progress in brain researchSensitivity of alpha band ERD to individual differences in cognition
61 Citations2006Aljoscha C. Neubauer, Andréas Fink +1 more
This chapter argues in favor of a more differentiated picture of the event-related desynchronization phenomenon, emphasizing the role of participants' sex, task complexity, and material specificity, as well as the importance to select an adequate external criterion (intelligence measure).
Psychiatry Research NeuroimagingEfficiency of working memory encoding in twins discordant for schizophrenia
15 Citations2009Peter Bachman, Junghoon Kim +8 more
An inefficiency model of neurocognitive dysfunction in schizophrenia appears during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation.
