Inhibitory potentials produced in cortical cells by stimulation of the lateral hypothalamus in rabbits
Brain ResearchPublished 1 July 1976
Tomio Arikuni
Citations18
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In some non-PT cells, EPSPs which occasionally resulted in spike discharges were observed after LH stimulation, and a sequence of brief depolarization and prolonged hyperpolarization occurred in response to LH stimulation.
Abstract
(1) Intracellular potentials were recorded from pyramidal tract (PT) and non-pyramidal tract (non-PT) cells of the frontal cortex in urethane-anesthetized rabbits and the effects of electrical stimulation of the lateral hypothalamus (LH) were examined on the ipsilateral side. (2) Latencies of antidromic spikes of PT cells evoked by stimulation of the medullary pyramidal tract (PYR) had a unimodal distribution with the mean at 4.0 msec. The mean conduction velocity of the pyramidal tract fibers was 10.5 m/sec. (3) Prolonged IPSPs were produced in PT and non-PT cells by single shock stimulation of LH (LH-IPSP). They were significantly longer lasting than those produced by PYR stimulation (PYR-IPSP). (4) The latencies of LH-IPSPs ranged from 1.7 to 25.0 msec and were divided into two groups. The latencies of PYR-IPSPs had a unimodal distribution ranging from 2.5 to 30 msec. (5) In a few non-PT cells, a sequence of brief depolarization and prolonged hyperpolarization occurred in response to LH stimulation. (6) In some non-PT cells, EPSPs which occasionally resulted in spike discharges were observed after LH stimulation. However, no excitation of PT cells was observed by LH stimulation.
Keywords
MedicineNeuroscience
Acta Physiologica ScandinavicaStereotaxic Mapping of the Monoamine Pathways in the Rat Brain*
3,818 Citations1971Urban Ungerstedt
The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions, indicating a unique role for the locus coeruleus in influencing the activity of the entire brain.
The Journal of PhysiologyCholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones
1,186 Citations1954J. C. Eccles, P. Fatt +1 more
The Journal of Comparative NeurologyA radioautographic study of the efferent pathways of the nucleus locus coeruleus
507 Citations1974Virginia M. Pickel, Menahem Segal +1 more
The distribution of label from LC provides direct confirmation for connections which have been difficult to visualize in their entirety by any other histological or cytochemical method.
Brain ResearchMesencephalic dopamine neurons projecting to neocortex
505 Citations1974Olle Lindvall, Anders Björklund +2 more
The physiology of nerve cells
397 Citations1975Derek Henry Paul
The physiology of nerve cells is studied in detail in order to understand the role of Tournaisian reprograming and its applications in medicine.
Brain ResearchStudies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. II. Sensitivity of Purkinje cells to norepinephrine and related substances administered by microiontophoresis
357 Citations1971Barry J. Hoffer, George R. Siggins +1 more
Brain ResearchHistochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways
279 Citations1974Brigitte Berger, Jean‐Pol Tassin +3 more
ScienceAdenosine 3′,5′-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission
243 Citations1972Donald A. McAfee, Paul Greengard
It is hypothesize that the slow inhibitory postsynaptic potential as well as the dopamine-induced hyperpolarization result from increased amounts of adenosine 3'5'-monophosphate in the postganglionic neurons.
Brain ResearchSubcortical afferents to the frontal lobe in the rhesus monkey studied by means of retrograde horseradish peroxidase transport
221 Citations1975J. Kievit, H.G.J.M. Kuypers
In the rhesus monkey, retrogradely labeled neurons, containing HRP reaction granules in the cell body and proximal parts of the dendrites, were present in the thalamus as well as in the substantia innominata and the hypothalamus and the latter areas will be referred to as the basal forebrain areas.
NatureDissociation of Electrocortical Activation and Behavioural Arousal
146 Citations1962Samuel M. Feldman, Hardress J. Waller
The present experiments were designed to test the following hypothesis: while the ascending reticular system mediates electrocortical ‘tone’, the posterior hypothalamic region has a functionally separable role in maintaining the waking state.
The Journal of PhysiologyElectrophysiological investigations on Renshaw cells
139 Citations1961J. C. Eccles, Rosamond M. Eccles +2 more
In the present investigation synaptic stimulation of Renshaw cells has been examined both by studying the effect of variation in intensity of tlle stimulus on the time course of the repetitive response, and by employing intracellular recor(ding to give the time Course of the synaptically induced response.
The Journal of PhysiologyUnitary activity of spinal interneurones of cats
137 Citations1956K. Frank, M. G. F. Fuortes
The majority of the responses described in this paper were probably recorded from axons and therefore might have been led off from fibres belonging to long descending pathways, but this limitation does not apply to responses obtained after very short central times but cannot be ruled out in other instances.
Experimental NeurologyProperties of the pyramidal system in the cat
119 Citations1963A.L. Towe, Harry D. Patton +1 more
Responsibility characteristics of 833 neurons in the pericruciate cortex of the cat were studied to find which sent axons into the medullary pyramids.
The Journal of PhysiologyCortical pyramidal tract interneurones and their sensitivity to L‐glutamic acid
97 Citations1973Trevor W. Stone
Pyramidal tract interneurones have been identified in the rat cerebral cortex and stimulation in a specific thalamic nucleus produced a burst of activity lasting for up to 1 sec.
Experimental Brain ResearchDemonstration by degeneration silver method of the ascending projection from the locus ceruleus
74 Citations1974N. Shimizu, S. Ohnishi +2 more
The trajectory and distribution of the cerulo-cortical tract as revealed by the silver degeneration methods is in agreement with the results of the histofluorescence method, with some minor differences.
Brain ResearchDetailed noradrenaline pathways of locus coeruleus neuron to the cerebral cortex with use of 6-hydroxydopa
67 Citations1974Masaya Tohyama, Toshihiro Maeda +1 more
Brain ResearchIdentification of possible inhibitory neurons in the pericruciate cortex of the cat
45 Citations1974Leo P. Renaud, John Kelly
It is suggested that someI-type neurons may represent cortical inhibitory neurons, and these findings suggest that some pyramidal and non-pyramidal tract neurons could be decreased by localized intracortical microiontophoretic (glutamate) stimulation of neighboring non- pyramid tract neurons.
Neurologia medico-chirurgica4. HYPOTHALAMIC ACTIVATION UPON ELECTRICAL ACTIVITIES OF PALEO- AND ARCHICORTEX
41 Citations1960T Tokizane, Hiroshi Kawamura +1 more
Naunyn-Schmiedeberg s Archives of PharmacologyDopamine-induced inhibition of synaptic transmission in lumbar paravertebral ganglia of the dog
34 Citations1973J. Willems
Dopamine is injected into the lumbar aorta in doses which produce a neurogenic vasodilatation in the isolated perfused hindleg of the dog, and the possibility that the dopamine-induced ganglionic inhibition is mediated via specific dopamine receptors is discussed.
Brain ResearchSimultaneous recordings from pericruciate pyramidal tract and non-pyramidal tract neurons; response to stimulation of inhibitory pathways
26 Citations1974Leo P. Renaud, John Kelly
The different activity patterns of PT and non-PT neurons may be related to some of the known morphological differences between cortical pyramidal and stellate neurons.