Cervical papillomaviruses segregate within morphologically distinct precancerous lesions
Journal of VirologyPublished 1 June 1985Open access
Christopher P. Crum, Masaru Mitao, Richard U. Levine, Saul J. Silverstein
Citations215
SJR quartileQ1
SJR score1.28
SNIP0.90
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TL;DR
The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancerous changes that have a high risk of progression.
Abstract
We combined molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix to correlate the presence of certain strains of human papillomaviruses (HPVs) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPVs.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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