Corticosteroids, IgE, and atopy
Journal of Clinical InvestigationPublished 1 February 2001Open access
Peter J. Barnes
Citations68
SJR quartileQ1
SJR score4.72
SNIP2.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Corticosteroids inhibit the transcription of IL-4, IL-5, and IL-13 genes, and it is likely that switching off these key cytokines contributes importantly to their efficacy in controlling allergic diseases.
Keywords
Medicine
The LancetEffects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
1,816 Citations2000Margaret J Leckie, Anneke Ten Brinke +12 more
A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosInophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy, however, the findings question the role of eos inophils in mediating the late asthmatic response and causing airway hyper-responsiveness.
Clinical ScienceAnti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
1,572 Citations1998Peter J. Barnes
This new understanding of glucocorticoid mechanisms may lead to the development of novel steroids with less risk of side effects (which are due to the endocrine and metabolic actions of steroids), and 'Dissociated' steroids which are more active in transrepression than transactivation (GRE binding) have now been developed.
CellDNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival
1,071 Citations1998Holger M. Reichardt, Klaus H. Kaestner +9 more
A point mutation A458T is introduced into the GR by gene targeting using the Cre/loxP system, impairs dimerization and therefore GRE-dependent transactivation while functions that require cross-talk with other transcription factors, such as transrepression of AP-1-driven genes, remain intact.
CellThe CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
824 Citations1993Alejandro Aruffo, Mary Farrington +13 more
It is reported that patients with hyper-IgM syndrome (HIM) have a defective gp39-CD40 interaction, which suggests that a defect in gp39 is the basis of X-linked HIM.
Molecular and Cellular BiologyGlucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12
718 Citations2000Kazuhiro Ito, Peter J. Barnes +1 more
New England Journal of MedicineTreatment of Allergic Asthma with Monoclonal Anti-IgE Antibody
707 Citations1999Henry Milgrom, Robert B. Fick +5 more
A recombinant humanized monoclonal antibody directed against IgE has potential as a treatment for subjects with moderate or severe allergic asthma and was well tolerated.
Journal of Allergy and Clinical ImmunologyA comparative study of the effects of an inhaled corticosteroid, budesonide, and a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double-blind, parallel-group controlled trial
584 Citations1992L. Laitinen, A LAITINEN +1 more
It is concluded that, in contrast to inhaled terbutaline, inhaled budesonide improved lung function and bronchial hyperreactivity in adult subjects with asthma treated for 3 months and that this corticosteroid was more effective in ameliorating abnormalities of theBronchial epithelium and decreasing inflammation in the airways.
The Journal of Experimental MedicineRecombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.
403 Citations1992Melanie K. Spriggs, Richard J. Armitage +6 more
Northern blot and FACS analyses suggest that the hCD40-L is restricted in its expression to T lymphocytes, and that it is most abundant on the CD4+ T cell subpopulation.
Case Reports in DermatologySuccessful Treatment of a Bullous Pemphigoid Patient with Rituximab Who Was Refractory to Corticosteroid and Omalizumab Treatments
363 Citations2017Aslı Bilgiç Temel, Cumhur İbrahim Başsorgun +3 more
The case of a young BP patient who responded well to rituximab therapy and was refractory to conventional and omalizumab therapies although he had elevated IgE levels and eosinophilia supports the knowledge about the effectiveness and safety of ritUXimab not only in pemphigus but also in BP.
Clinical & Experimental ImmunologyThe modulation of B7.2 and B7.1 on B cells by immunosuppressive agents
265 Citations1999Orathai Jirapongsananuruk, Donald Y.M. Leung
Investigation of the effect of immunosuppressive agents, cyclosporin A and dexamethasone, on B 7.2 and B7.1 expression on B cells found that T cell engagement of CD40 plays a role in the mechanisms by which CsA and Dexameth asone acts on B Cells, suggesting that Th1‐driven allergic diseases may be of benefit for the treatment of Th2‐driven allergy diseases.
The Journal of ImmunologyProstaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness
206 Citations1998Changyou Wu, Kening Wang +2 more
The PGE2- and DXM-mediated inhibition of IL-12R expression was not affected significantly by addition of neutralizing Abs against either IL-4, IL-10, or TGF-beta, and addition of dibutyryl cAMP, 8-bromoadenosine 3:5 cAMP (8-Br-cAMP), or cholera toxin substantially reduced IL- 12R expression.
BloodDifferential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro
201 Citations1998Jeroen Visser, Anette H.H. van Boxel-Dezaire +4 more
Results indicate that GC may favor Th2 development by differential regulation of IL-10 and IL-12, and in the presence of neutralizing anti-IL-10 antibodies, DEX was still capable ofIL-12 suppression whereas RU486 still enhanced Il-12 production, indicating that GC do not modulate IL- 12 via IL- 10 exclusively.
The Journal of ImmunologyHydrocortisone and IL-4 induce IgE isotype switching in human B cells
154 Citations1991Haifa H. Jabara, Deborah Ahern +2 more
IgE synthesis was induced in sorted CD5- B cells, indicating that the ability to produce IgE in response to HC and IL-4 is not constrained by CD5 expression, and suggest that hormones may play an important role in the regulation of IgE synthesis.
Journal of Allergy and Clinical ImmunologyIn vivo effects of glucocorticoids on IgE production
121 Citations1994Zieg, Lack +5 more
The data suggest that the observed rise in IgE production associated with prednisone treatment is not clinically deleterious but reflects the immunomodulatory effects of corticosteroids on T lymphocytes.
Journal of Clinical InvestigationGlucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching
75 Citations2001Haifa H. Jabara, Scott R. Brodeur +1 more
It is demonstrated that hydrocortisone fails to induce IgE synthesis in B cells from CD40 ligand-deficient (CD40L- deficient) patients, and lig and-mediated activation of the glucocorticoid receptor upregulates CD40L expression in human lymphocytes.
Journal of Immunology ResearchGlucocorticoids Induce a TH2 Response <i>In Vitro</i>
58 Citations1997Francisco Ramı́rez
Journal of Allergy and Clinical ImmunologyIn vivo effects of glucocorticoids on IgE production
53 Citations1994George Zieg, Gideon Lack +3 more
International Archives of Allergy and ImmunologyAnti-IgE Therapy in Asthma: Rationale and Therapeutic Potential
42 Citations2000Peter J. Barnes
The clinical effectiveness of rhuMAb-E25 supports the central role of IgE in allergic reactions and the viability of anti-IgE therapy as a potentially effective treatment option for asthma.
Cellular ImmunologyGlucocorticoids Inhibit CD40 Ligand Expression of Peripheral CD4+Lymphocytes
25 Citations1998Felix Bischof, Arthur Melms
It is shown that dexamethasone in vitro inhibits CD40L expression in a dose-dependent manner in concentrations ranging from 0.1 to 1 mg/mL, and that this effect was due to inhibition ofCD40L transcription.
