Executive Dysfunction in Geriatric Depression
American Journal of PsychiatryPublished 1 July 2002
Kathryn A. Lockwood, George S. Alexopoulos, Wilfred G. van Gorp
Citations382
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
The findings can guide the development of stimulated functional neuroimaging paradigms that may clarify the pathophysiology of geriatric depression and lead to compensatory strategies that will improve the outcomes of late-life depression.
Abstract
Patients with late-life depression have significant impairment in executive functioning. These findings can guide the development of stimulated functional neuroimaging paradigms that may clarify the pathophysiology of geriatric depression. Timely identification of attentional and executive processes fundamental to the daily functioning of depressed older adults may lead to compensatory strategies that will improve the outcomes of late-life depression.
Keywords
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Journal of Psychiatric Research“Mini-mental state”
86,858 Citations1975Marshal F. Folstein, Susan E. Folstein +1 more
A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
British Journal of Social and Clinical PsychologyDevelopment of a Rating Scale for Primary Depressive Illness
8,470 Citations1967Max Hamilton
This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Archives of General PsychiatryResearch Diagnostic Criteria
6,963 Citations1978Robert L. Spitzer
The development and initial reliability studies of a set of specific diagnostic criteria for a selected group of functional psychiatric disorders, the Research Diagnostic Criteria (RDC), indicate high reliability for diagnostic judgments made using these criteria.
NatureSubgenual prefrontal cortex abnormalities in mood disorders
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Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
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Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood, suggesting that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions.
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Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders.
NeuroreportCingulate function in depression
1,039 Citations1997Helen S. Mayberg, Stephen K. Brannan +9 more
A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed and may represent an important adaptive response to depression and failure of this response may underlie poor outcome.
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720 Citations1992Christopher J. Bench, Karl Friston +4 more
An anatomical dissociation has been described between the rCBF profiles associated with depressed mood and depression-related cognitive impairment, which may be functionally abnormal in major depressive disorder.
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Archives of General PsychiatryCerebral Metabolic Rates for Glucose in Mood Disorders
602 Citations1985Lewis R. Baxter
The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state, and patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole.
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558 Citations1997George S. Alexopoulos, Barnett S. Meyers +4 more
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Psychological MedicineNeuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance
473 Citations1996Rebecca Elliott, Barbara J. Sahakian +4 more
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Psychological MedicineCognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed
467 Citations1996Barbara Beats, Barbara J. Sahakian +1 more
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American Journal of PsychiatryLeft prefrontal glucose hypometabolism in the depressed state: a confirmation
465 Citations1990Jean‐Luc Martinot, P. Hardy +6 more
The resting-state cerebral metabolic rates for glucose of severely depressed patients were compared, before and after treatment with tricyclic antidepressants, to those of 10 control subjects of similar age by means of positron emission tomography and the fluorodeoxyglucose method.
Psychiatry ResearchThe continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients
398 Citations1989Barbara A. Cornblatt, Mark F. Lenzenweger +1 more
Performance on a secondary task in response to a change in expectation improved dramatically for depressed but not schizophrenic patients, suggesting a more efficient allocation strategy, a greater reserve of processing capacity, or more dependence on motivational factors in depressed patients.
Journal of Affective DisordersFrontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness
370 Citations1986Monte S. Buchsbaum, Joseph C. Wu +8 more
Patients with bipolar affective illness had significantly lower frontal to occipital glucose metabolic rate ratios (relative hypofrontality) and significantly lower metabolic rates in their basal ganglia in comparison to whole slice metabolism than normal controls and patients with unipolar illness showed significantly higher frontal to Occipital ratios, and also showed relatively decreased metabolism in the basal Ganglia.
Archives of General PsychiatryMagnetic Resonance Imaging of the Caudate Nuclei in Depression
366 Citations1992K.Ranga Rama Krishnan
Caudate nucleus volumes in depressed patients were inversely correlated with the bicaudate and bifrontal indices and a role for the caudate nucleus in the pathogenesis of major depression is suggested.
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DepressionPrefrontal cortex dysfunction in clinical depression
319 Citations1994Mark S. George, Terence A. Ketter +1 more
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Neurobiology of AgingMorphometry of the human cortex cerebri and corpus striatum during aging
297 Citations1991Herbert Haug, Reinhard Eggers
The commentary is based on the results of biological aging research with the following findings: a loss of neurons cannot be found, the size of neurons and the number of synapses decrease with age, the various regions of brain react quite differently.
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271 Citations1996George S. Alexopoulos, C Vrontou +5 more
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The findings were consistent with the view that depressed participants fail to use appropriate performance strategies spontaneously to the same extent as controls, however, provision of information alone does not seem to be an adequate means of enhancing performance.
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54 Citations1990June Corwin, Eric D. Peselow +3 more
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33 Citations1988Barbara Jones, Mary P. Henderson +1 more
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As predicted, significant interactions indicated that age differences in search were eliminated under the fixed set procedure but not under the varied set procedure.
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