The neurobiology of aging: Does it predispose to depression?
Neurobiology of AgingPublished 1 January 1988
Richard C. Veith, Murray A. Raskind
Citations58
SJR quartileQ1
SJR score1.45
SNIP0.92
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TL;DR
This review examines the various research approaches undertaken to investigate possible central nervous system correlates of major depressive illness and relates findings from these studies to the alterations incentral nervous system and neuroendocrine function that normally accompany aging in humans.
Abstract
This review examines the various research approaches undertaken to investigate possible central nervous system correlates of major depressive illness and relates findings from these studies to the alterations in central nervous system and neuroendocrine function that normally accompany aging in humans. The topics reviewed include: epidemiology of depression and suicide in the elderly; monoamine theories of depression; neuroendocrine disturbances in depression; and imaging studies.
Keywords
MedicineNeuroscience
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The Journal of Clinical Endocrinology & MetabolismThe Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*
598 Citations1985Zvi Zadik, A. CHALEW +3 more
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Archives of General PsychiatryPsychiatric Disorders in the Biological and Adoptive Families of Adopted Individuals With Affective Disorders
556 Citations1986Paul H. Wender
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Archives of General PsychiatryIncreased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims
550 Citations1986J. John Mann
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Archives of General PsychiatryThe Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry
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Neural pepetides and neuronal communication, Neural pepeteides and neurons communication, کتابخانه مرکزی ایران .
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187 Citations1979Patricia N. Prinz, Jeffrey B. Halter +2 more
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184 Citations1980Salomón Z. Langer, Michael S. Briley +3 more
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183 Citations1985Alec Roy
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179 Citations1979James W. Maas, Susan E. Hattox +2 more
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171 Citations1981David J. Kupfer, Duane G. Spiker +4 more
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Journal of the American Geriatrics SocietySymptomatic Depression in Elderly Medical Outpatients
162 Citations1986Soo Borson, Robert A. Barnes +6 more
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161 Citations1985Julien Mendlewicz, Paul Linkowski +5 more
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160 Citations1971C. G. Gottfries, I. Gottfries +5 more
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158 Citations1984D J Reis, Antonio Granata +4 more
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143 Citations1975Peter Gruen
Human growth hormone responses to insulin-induced hypoglycemia were measured in ten postmenopausal women suffering from primary unipolar depressive illness, and in ten age-matched normal post menopausal women.
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The potency of the atropine-induced suppression of GH secretion by three different stimuli, each with presumably different mechanisms of action, suggests that acetylcholine plays an important role in the regulation ofGH secretion.
American Journal of PsychiatryScreening for depression in geriatric medical patients
140 Citations1982Joseph T. Okimoto, Robert Barnes +4 more
The authors identify six items from the Zung Self-Rating Depression Scale that may serve as a simple screening instrument for the detection of depression in geriatric medical patients.
AnesthesiologyEffect of Spinal Anesthesia on Adrenergic Tone and the Neuroendocrine Responses to Surgical Stress in Humans
139 Citations1981A. Eugene Ptlug, Jeffrey B. Halter
Archives of General PsychiatryBiochemical and Functional Evidence of Supersensitive Platelet α2-Adrenoceptors in Major Affective Disorder
139 Citations1986Jesús A. Garcı́a-Sevilla
Major effective disorder may be related to a dysfunction of the high-affinity state of the alpha 2-adrenoceptor that recognizes agonists and mediates physiological effects.
Journal of the American Geriatrics SocietyScreening for Depression in Hospitalized Geriatric Medical Patients
136 Citations1982Margaret Kitchell, Robert Barnes +3 more
Although performance on both scales is reduced compared with that of younger depressed patients, these self‐rating scales appear to be useful aids for the detection of depression in geriatric medical patients.
Journal of GerontologyAging-induced Changes in Acetylcholine and Serotonin Content of Discrete Brain Nuclei
131 Citations1977J.L. Meek, Leif Bertilsson +3 more
Journal of Affective DisordersThe Dexamethasone Suppression Test in mania
131 Citations1982P.M. Graham, John D. Booth +5 more
Twenty-three cases showed an absence of normal suppression, results which are similar to those seen in endogenous depression and which differ to those of others who have all reported normal suppression in mania.
Archives of General PsychiatryReduced Growth Hormone Responses to Amphetamine in "Endogenous" Depressive Patients
131 Citations1976Gerhard Langer
Amphetamine sulfate is introduced as a stimulus for human growth hormone release in various psychiatric patients and peak HGH release in eight schizophrenics and six chronic alcoholics did not differ significantly from that in normal subjects.
Archives of General PsychiatryIncreased Plasma MHPG in Dexamethasone-Resistant Depressed Patients
130 Citations1983David C. Jimerson
The results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.
American Journal of PsychiatryCerebral blood flow in depression
128 Citations1980Roy J. Mathew, Jerrold S. Meyer +4 more
This section contains new research findings, including preliminary data from pilot studies, either clinical or laboratory; worthwhile replication studies; and case reports that indicate a new therapeutic procedure of potential value or call attention to adverse effects of drugs or previously unreported complications of therapeutic interventions.
Journal of Histochemistry & CytochemistryThyrotropin releasing hormone, somatostatin, and enkephalin: distribution studies using immunohistochemical techniques.
128 Citations1980O Johansson, Tomas Hökfelt
Using the indirect immunofluorescence technique of Coons and collaborators, the localization of thyrotropin releasing hormone, somatostatin, and enkephalin was studied in the rat central nervous system and the neuropeptides were traced at the ultrastructural level.
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