Increased Plasma MHPG in Dexamethasone-Resistant Depressed Patients
Archives of General PsychiatryPublished 1 February 1983
David C. Jimerson
Citations130
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TL;DR
The results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.
Abstract
Severely depressed patients frequently show inadequate suppression of serum cortisol levels by dexamethasone. In a study of 15 depressed patients, we found a robust correlation between plasma levels of cortisol and 3-methoxy-4-hydroxy-phenylglycol after dexamethasone administration. These results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.
Keywords
MedicineNeuroscience
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