Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes
SciencePublished 8 May 1981
Jean Claude Willer, H Dehen, J Cambier
Citations335
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man and reverse the effect of naloxone on this threshold.
Abstract
The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. Tha data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.
Keywords
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