Enantioselective Thiourea‐Catalyzed Acyl‐Mannich Reactions of Isoquinolines
Angewandte Chemie International EditionPublished 21 September 2005Open access
Mark S. Taylor, Norihito Tokunaga, Eric N. Jacobsen
Citations289
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
Inexpensive aromatic feedstocks are substrates for highly enantioselective acylative Mannich reactions catalyzed by a thiourea chiral hydrogen-bond donor 1. This methodology provides access to useful 1-substituted dihydroisoquinolines (see scheme; TrocCl=2,2,2-trichloroethyl chloroformate, TBS=tert-butyldimethylsilyl), which serve as precursors to enantioenriched 1-substituted tetrahydroisoquinolines.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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