Genetic and biophysical basis for bupivacaine-induced ST segment elevation and VT/VF. Anesthesia unmasked Brugada syndrome
Heart RhythmPublished 8 July 2006Open access
Kevin Vernooy, Serge Sicouri, Robert Dumaine, Kui Hong, Antonio Oliva, Elena Burashnikov
Citations61
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TL;DR
Findings indicate that bupivacaine may induce the electrocardiographic and arrhythmic manifestations of the Brugada syndrome in silent carriers of SCN5A mutations, which has important implications in the management of patients who develop ST segment elevation when under the influence of anesthetics such as bupvacaine.
Abstract
Our findings indicate that bupivacaine may induce the electrocardiographic and arrhythmic manifestations of the Brugada syndrome in silent carriers of SCN5A mutations. The data have important implications in the management of patients who develop ST segment elevation when under the influence of anesthetics such as bupivacaine.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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