Antigen Receptors of T Helper Cells

Since each receptor molecule carries associated with its specific antigen-binding site specific antigenic determinants (so-called idiotopes) that distinguish it from, and can be recognized by, other receptor molecules, it appears possible that the immune system regulates itself by internal receptor-receptor interactions.

Abstract

The function of the immune system is based on a large variety of receptor molecules that differ in their binding specificity. These receptors are located in part on the surfaces of the immunocompetent cells, namely, T and B lymphocytes, and in part appear free in the circulation. They mediate the specific recognition of antigens and guarantee the specificity of the immunologic reactions that follow antigen recognition. In addition, since each receptor molecule carries associated with its specific antigen-binding site specific antigenic determinants (so-called idiotopes) that distinguish it from, and can be recognized by, other receptor molecules, it appears possible that the immune system regulates itself by internal receptor-receptor interactions (Jerne, 1974).