Novel Neurotransmitters and Their Neuropsychiatric Relevance
American Journal of PsychiatryPublished 1 November 2000
Solomon H. Snyder, Christopher D. Ferris
Citations261
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
D-Serine, recently appreciated as the endogenous ligand for the glycine site of the glutamate N-methyl-D-aspartate (NMDA) receptor, overturns fundamental axioms of biology as well as those of neuroscience.
Abstract
The diversity of novel neurotransmitters and venues of their activity afford multiple opportunities for therapeutic intervention.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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223 Citations1994Mollie K. Meffert, Jane E. Haley +3 more
Together these data do not support carbon monoxide as a mediator in either LTP induction or expression/maintenance and emphasize further the nonselectivity of some metalloporphyrins.
Proceedings of the National Academy of Sciences<scp>d</scp> -aspartate localizations imply neuronal and neuroendocrine roles
221 Citations1997Michael J. Schell, Odelia Cooper +1 more
Localizations of D-aspartate oxidase are reciprocal to D- aspartate, suggesting that the enzyme depletes endogenous stores of the amino acid and might inactivate synaptically released D-Aspartate.
Journal of Clinical InvestigationOxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.
215 Citations1998Phyllis A. Dennery, Douglas R. Spitz +5 more
It is suggested that HO-2 functions to augment the turnover of lung iron during oxidative stress, and that this function does not appear to be compensated for by induction of HO-1 in the knockouts.
Neuroscience LettersFree d-serine, d-aspartate and d-alanine in central nervous system and serum in mutant mice lacking d-amino acid oxidase
206 Citations1993Atsushi Hashimoto, Toru Nishikawa +5 more
It is found that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-Serine level is observed between the two strains.
Digestive Diseases and SciencesDiabetic Gastropathy (Gastric Neuromuscular Dysfunction in Diabetes Mellitus A Review of Symptoms, Pathophysiology, and Treatment)
199 Citations1999Kenneth L. Koch
Diabetic gastropathy is a term that encompasses a number of neuromuscular dysfunctions of the stomach, including abnormalities of gastric contractility, tone, and myoelectrical activity in patients with diabetes.
Proceedings of the National Academy of SciencesCarbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes
199 Citations2000L. Xue, Gianrico Farrugia +4 more
Life SciencesInvolvement of D-Aspartic acid in the synthesis of testosterone in rat testes
191 Citations1996Autimo D'Aniello, Anna Di Cosmo +4 more
The results suggest that free D-Asp is involved in the steroidogenesis, and it is demonstrated that this amino acid induces the synthesis of testosterone.
Advances in PediatricsBilirubin Metabolism and Kernicterus
189 Citations1997Glenn R. Gourley
In the United States, there is currently no generally accepted method to predict hyperbilirubinemia or kernicterus, and more research is needed to improve the understanding about the entry of bilirubin into the brain, the predilection of bil irubin for certain brain regions, and the cytotoxicity of bilIRubin.
Advances in pharmacologyNitric Oxide Synthases: Gene Structure and Regulation
185 Citations1995Yang Wang, Philip A. Marsden
Given the essential role of the NO pathway in a wide variety of physiological and pathophysiological process, it is possible that the three isoforms of NOS contribute to polygenic genetic diversity in neurological, immune, and cardiovascular biology.
European Journal of PharmacologyNon-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction
183 Citations1990Guy E. Boeckxstaens, Paul A. Peickmans +4 more
It is suggested that NO or a NO releasing substance mediates the NANC relaxation in the canine terminal ileum and ileocolonic junction.
NatureOpiate receptor in normal and drug altered brain function*
183 Citations1975Solomon H. Snyder
The isolation of a morphine-like peptide which may be a central nervous system neurotransmitter sheds light on normal brain mechanisms regulating pain and emotion.
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