Regulatory Mechanisms in the Control of Protein Kinase
Critical Reviews in BiochemistryPublished 1 January 1982
David A. Flockhart, Jackie D. Corbin
Citations355
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Abstract
(1982). Regulatory Mechanisms in the Control of Protein Kinase. Critical Reviews in Biochemistry: Vol. 12, No. 2, pp. 133-186.
Keywords
Biochemistry, Genetics and Molecular Biology
Archives of NeurologyHandbook of Physiology.
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This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
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Epidermal growth factor-enhanced protein kinase activity in plasma membrane preparations of A-431 human epidermoid carcinoma cells was shown to involve the phosphorylation of tyrosine residues, which was detected in both endogenous membrane proteins and in histone when added as an exogenous protein substrate.
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A protein kinase which phosphorylated histone and protamine was partially purified from bovine cerebellum and preliminary analysis suggested that the enzyme was produced from its precursor protein by a limited proteolytic reaction.
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564 Citations1975Franz Hofmann, JA Beavo +2 more
Homogeneous preparations of adenosine 3':5'-monophosphate (cyclic AMP)-dependent protein kinase from rabbit skeletal (Peak I) and bovine heart muscle have been compared and several differences were found.
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Journal of Biological ChemistryRapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.
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Findings suggest that one of the biochemical consequences of the binding of EGF to membranes is a rapid activation of a cyclic AMP-independent phosphorylating system.
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It is reported here that the soluble phosphotransferase activity of partially purified pp60src results in the phosphorylation of exclusively tyrosine residues in a variety of proteins that serve as substrates.
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In most of the cases investigated, at least two peaks of cAMP-dependent activity can be separated by chromatography on DEAE-cellulose and these fractions will be referred to as peak I and peak II protein kinase in communication.
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456 Citations1978Graham Carpenter, Lloyd E. King +1 more
It is reported that membranes may be prepared from A-431 cells that retain the ability to bind 125I-labelled EGF in a specific manner, and the binding of EGF to these membranes in vitro results in a marked stimulation of the phosphorylation of endogenous proteins in the presence of [γ-32P]ATP.
BiochemistryConcerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations
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It is reported here that phosphorylation of platelet myosin results in an increase in the actin-activatedMyosin ATPase activity measured at low ionic strength.
Journal of Biological ChemistryThe Regulation of Skeletal Muscle Phosphorylase Kinase by Ca2+
418 Citations1971Charles O. Brostrom, Felix L. Hunkeler +1 more
A model system is proposed for the regulation of skeletal muscle phosphorylase kinase by Ca2+ in vivo, and the consequent linking of the process of glycogenolysis to that of muscle contraction.
Biochemical JournalRegulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide
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Proceedings of the National Academy of SciencesCharacterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).
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The sites of tyrosine phosphorylation in the transforming protein of Rous sarcoma virus and its normal cellular homologue (pp60c-src) are characterized to define what may prove to be a widely used site for tyrosines phosphorylated in the regulation of cellular function.
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The concept that arginine is an important residue in determining the substrate specificity of the protein kinase, predominantly influencing the Vmax of the phosphorylation reaction, is supported.
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197 Citations1976R Rangel-Aldao, O M Rosen
The degree to which the cyclic AMP-binding protein is phosphorylated markedly affects its intrinsic ability to combine with the catalytic subunit to regenerate the inactive cyclic nucleotide-dependent kinase and that the state of phosphorylation of this subunit may be important in detemining the proportion of dissociated and reassociated protein kinase at any given time.
Journal of Biological ChemistryRegulation of Adenosine 3′,5′-Monophosphate-dependent Protein Kinase
192 Citations1973Thomas R. Soderling, Jackie D. Corbin +1 more
There was an apparent activation of the enzyme by NaF, but this effect was probably due to inhibition of adenosine triphosphatase activity, and sodium chloride was found to increase the activity ratio of the protein kinase in the presence of cAMP.
Proceedings of the National Academy of SciencesIsolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.
191 Citations1978Asher Zilberstein, Adi Kimchi +2 more
Two interferon-induced activities are isolated: a protein kinase system that is activatable by double-stranded RNA and ATP and that phosphorylates a Mr 67,000 protein and the smallest subunit of eukaryotic initiation factor-2, and an enzyme that slowly polymerizes ATP into oligoadenylate with a 2'-5' phosphodiester linkage.
Journal of Biological ChemistryEffects of adenosine 3':5'-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles.
191 Citations1976M A Kirchberger, Michihiko Tada
Increases in protein kinase-catalyzed phosphorylation of a low molecular weight microsomal component and in calcium transport by sarcoplasmic reticulum of cardiac and slow skeletal muscle may be related to the relaxation-promoting effects of epinephrine seen in these types of muscle.
Journal of Biological ChemistryCharacterization of a novel cGMP binding protein from rat lung.
178 Citations1980Sharron H. Francis, Thomas Lincoln +1 more
The characteristics of the cGMP binding protein-phosphodiesterase and its presence in several cell types, ie.
PubMedEpidermal growth factor-receptor-protein kinase interactions.
178 Citations1981Sagit Cohen-Schwartz, G Carpenter +1 more
These findings suggest that one of the biochemical consequences of the binding of EGF to membranes is a rapid activation of a cyclic AMP-independent phosphorylating system and the activation of the membrane-associated protein kinase by EGF appears to be a reversible phenomenon.
Journal of Biological ChemistryThe role of calcium ion as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes.
177 Citations1979James C. Garrison, M. Kate Borland +2 more
The results imply that angiotensin II, catecholamines, and vasopressin control hepatic carbohydrate metabolism through a Ca2+-requiring, cyclic AMP-independent pathway that leads to the phosphorylation of important regulatory enzymes.
Journal of Biological ChemistrySubstrate binding closes the cleft between the domains of yeast phosphoglycerate kinase.
172 Citations1979Clifford A Pickover, David McKay +2 more
The apparent similarity of the ligand-induced change in phosphoglycerate kinase to the cleft closure in hexokinase suggests that this kind of conformational change may prove to be a rather general kinase phenomenon.
Biochimica et Biophysica Acta (BBA) - EnzymologyUDP-glucose: glycogen α-4-glucosyltransferase I kinase activity of purified muscle protein kinase
170 Citations1969Keith K. Schlender, Siming Wei +1 more
A purified protein kinase obtained from rabbit skeletal muscle catalyzed the conversion of transferase I to transferase D and activated phosphorylase b kinase (phosphorylases b kin enzyme kinase activity) and catalyzing the phosphorylation of casein.
BiochemistryPhysicochemical properties of rabbit skeletal muscle phosphorylase kinase
169 Citations1973Taro Hayakawa, John P. Perkins +2 more
Journal of Biological ChemistryThe role of cyclic AMP in aldosterone production by isolated zona glomerulosa cells.
168 Citations1979Keisuke Fujita, G. Aguilera +1 more
The results indicate that the actions of ACTH on aldosterone secretion are mediated by cyclic AMP formation, whereas A II and potassium stimulate ald testosterone production through an independent mechanism.
Journal of Biological ChemistryPurification and subunit composition of guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung.
166 Citations1977Thomas Lincoln, W L Dills +1 more
The guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung was purified to apparent homogeneity by affinity chromography using 8-2-aminoethylthio-cGMP coupled to Sepharose 4B, indicating that the enzyme was not dissociated into regulatory and catalytic components by the immobilized cGMP derivative.
BiochemistryNucleosides and nucleotides. XLVII. Conformation of purine mucleosides and their 5'-phosphates
161 Citations1972Morio Ikehara, Seiichi Uesugi +1 more
European Journal of BiochemistryThe Role of Calcium Ions, Calmodulin and Troponin in the Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle
157 Citations1980Philip Cohen
The regulation of the different forms of phosphorylase kinase by calcium ions, the δ-subunit and troponin have been investigated and the dephosphorylated form, termed phosphate kinase b, was found to be almost inactive below 1.0 μM calcium ions.
NatureAn endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum
157 Citations1978D Schlichter, J E Casnellie +1 more
The presence in the cerebellum of a soluble protein specifically phosphorylated by the cGMP-dependent protein kinase of that tissue is reported.
NatureHomology of myosin DTNB light chain with alkali light chains, troponin C and parvalbumin
155 Citations1976John H. Collins
Evidence is presented for a structural and evolutionary relationship between proteins which have central roles in the two types of regulatory systems, myosin-linked (thick filament) and actin- linked (thin filament) control.
Journal of Biological ChemistryRegulation of adenosine 3:5-monophosphate-dependent protein kinase.
155 Citations1975S L Keely, Jackie D. Corbin +1 more
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153 Citations1979Michael P. Walsh, Bernard Vallet +2 more
The isolated myosin light chain kinase, which is located primarily in the soluble fraction of bovine myocardium, has been isolated and purified approximately 1200-fold with 16% yield by a three-step procedure.
Biochimica et Biophysica Acta (BBA) - BiomembranesThe rate of calcium uptake into sarcoplasmic reticulum of cardiac muscle and skeletal muscle. Effects of cyclic amp-dependent protein kinase and phosphorylase b kinase
146 Citations1976Arnold Schwartz, Mark L. Entman +4 more
The two phosphorylating enzymes stimulated calcium uptake in the sarcoplasmic reticulum of a variety of muscles possessing different physiologic characteristics and different responses to drugs.
Journal of Biological ChemistrySequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3‘:5‘-monophosphate-dependent protein kinase.
145 Citations1979Sunao Shoji, Koiti Titani +2 more
The finding that phosphorylation of the catalytic subunit of bovine cardiac muscle cAMP-dependent protein kinase (type II) occurs on two discrete sites rather than at random suggests that it might be of physiological importance, e.g. in the regulation of enzyme activity.
Cold Spring Harbor Symposia on Quantitative BiologyThe Crystal and Molecular Structure of DIP-inhibited Bovine Trypsin at 2.7A Resolution
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143 Citations1975Ronald H. Cooper, Philip J. Randle +1 more
The inhibition of pyruvate oxidation by diabetes and by oxidation of fatty acids and ketone bodies is considered to be of crucial importance in the selection of fuels for respiration and in the metabolic changes in heart and other tissues in diabetes and starvation.
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein SynthesisControl of globin synthesis by hemin: Factors influencing formation of an inhibitor of globin chain initiation in reticulocyte lysates
142 Citations1972Martin Gross, M. Rabinovitz
Although the complete transition of proinhibitor to inhibitor in the ribosome-free supernatant fraction takes place over a period of 12 to 15 h, partially purified pro inhibitor can be converted to inhibitor within 15 min by reaction with N -ethylmaleimide or o -iodosobenzoate, suggesting that inhibitor formation may involve a specific conformational change in the proinhibited molecule.
Biochemical and Biophysical Research CommunicationsA relationship between Ca2+ sensitivity and phosphorylation of gizzard actomyosin
141 Citations1976M. O. Aksoy, Daniel M. Williams +2 more
The results suggest a relationship between phosphorylation and the Ca 2+ sensitive ATPase activity of gizzard actomyosin and the phosphorylating system is removed.
Journal of Biological ChemistryCyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase.
140 Citations1980Akio Yamazaki, Indira Sen +3 more
Two classes of high affinity, cGMP-specific binding sites have been found in association with a peripheral membrane protein in rod outer segments and they may be involved in the regulation of phosphodiesterase activity.
Proceedings of the National Academy of SciencesGuanosine 3′:5′-Cyclic Monophosphate-Dependent Phosphorylation of Endogenous Substrate Proteins in Membranes of Mammalian Smooth Muscle
136 Citations1974J E Casnellie, Paul Greengard
The finding of endogenous cyclic GMP-dependent protein kinase activity and associated substrate proteins in membrane fractions from mammalian organs containing smooth muscle raises the possibility that physiological actions of cyclicGMP in smooth muscle may be mediated by the phosphorylation of membrane proteins.
Journal of Biological ChemistryMechanism of self-phosphorylation of adenosine 3':5'-monophosphate-dependent protein kinase from bovine cardiac muscle.
135 Citations1976R Rangel-Aldao, O M Rosen
Three lines of evidence are presented to support the conclusions that the undissociated holoenzyme does not catalyze the phosphorylation of exogenous substrates but can undergo self-phosphorylation by an intramolecular reaction.
Journal of Biological ChemistryEffects of epinephrine and insulin on phosphopeptide metabolism in adipocytes.
133 Citations1976Joseph Avruch, Gemma Leone +1 more
In intact adipocytes, epinephrine acutely alters the phosphorylation of a large number of adipocyte peptides, partly at least, via activation of adenosine 3':5'-monophosphate (cyclic AMP)-dependent protein kinase, and insulin exerts a unique stimulatory effect on adipocytes' peptides.
Journal of Biological ChemistryPhysical Properties of a Purified Cyclic Adenosine 3′:5′-Monophosphate-dependent Protein Kinase from Bovine Heart Muscle
131 Citations1973Jack Erlichman, Charles S. Rubin +1 more
It is concluded that the native enzyme is composed of two catalytic units and one cyclic AMP-binding protein containing two polypeptide chains of equal size.
Biochemical JournalCalmodulin and myosin light-chain kinase of rabbit fast skeletal muscle
131 Citations1979Angus C. Nairn, S V Perry
Rabbit fast-skeletal-muscle calmodulin is indistinguishable from bovine braincalmodulin in its ability to activate myosin light-chain kinase and the other properties of these two proteins are also very similar.
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