Resting-state functional connectivity in major depressive disorder: A review
Neuroscience & Biobehavioral ReviewsPublished 30 July 2015
Peter Mulders, Philip van Eijndhoven, Aart H. Schene, Christian F. Beckmann, Indira Tendolkar
Citations859
SJR quartileQ1
SJR score3.08
SNIP2.62
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TL;DR
A model that incorporates changes in functional connectivity within current hypotheses of network-dysfunction in MDD is proposed and consistent findings correspond to the current understanding of depression as a network-based disorder.
Abstract
Major depressive disorder (MDD) affects multiple large-scale functional networks in the brain, which has initiated a large number of studies on resting-state functional connectivity in depression. We review these recent studies using either seed-based correlation or independent component analysis and propose a model that incorporates changes in functional connectivity within current hypotheses of network-dysfunction in MDD. Although findings differ between studies, consistent findings include: (1) increased connectivity within the anterior default mode network, (2) increased connectivity between the salience network and the anterior default mode network, (3) changed connectivity between the anterior and posterior default mode network and (4) decreased connectivity between the posterior default mode network and the central executive network. These findings correspond to the current understanding of depression as a network-based disorder.
Keywords
PsychologyNeuroscience
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186 Citations2014Chris Baeken, Daniele Marinazzo +8 more
Accelerated HF-rTMS treatment designs have the potential to acutely adjust deregulated sgACC neuronal networks in TRD patients and strong rsFC anti-correlation between the sg ACC and parts of the left prefrontal cortex could be indicative of a beneficial outcome.
Frontiers in PsychiatryReduced Intrinsic Connectivity of Amygdala in Adults with Major Depressive Disorder
183 Citations2014Rajamannar Ramasubbu, Nithya Konduru +4 more
Compared with HCs, MDD patients showed a wide-spread reduction in the intrinsic connectivity of the amygdala with a variety of brain regions involved in emotional processing and regulation, including the ventrolateral prefrontal cortex, insula, caudate, middle and superior temporal regions, occipital cortex, and cerebellum.
Psychological MedicineRegionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder
180 Citations2012Christopher G. Davey, Ben J. Harrison +2 more
The results reinforce the importance of subgenual ACC for depression, and show a close link between brain regions that support self-related processes and affective visceromotor function, using resting-state functional connectivity magnetic resonance imaging.
Molecular PsychiatryA functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression
169 Citations2014Jeroen A. van Waarde, H. Steven Scholte +4 more
It is suggested that resting-state networks have the potential to serve as prognostic neuroimaging biomarkers to guide personalized treatment decisions in patients with severe and treatment-resistant unipolar depression.
PLoS ONEResting-State Functional Connectivity Bias of Middle Temporal Gyrus and Caudate with Altered Gray Matter Volume in Major Depression
168 Citations2012Chaoqiong Ma, Jurong Ding +8 more
The gray matter reduction of right MTG and bilateral caudate, and disrupted functional connection to widely distributed circuitry in DMN and frontal regions, respectively are revealed, suggesting that the abnormalDMN and reward circuit activity might be biomarkers of depression trait.
Frontiers in PsychiatryElectroconvulsive Therapy Response in Major Depressive Disorder: A Pilot Functional Network Connectivity Resting State fMRI Investigation
162 Citations2013Chris Abbott, Nicholas T. Lemke +5 more
The differences between ECT remitters and non-remitters suggest that this increased FNC between p_DM areas and the left dorsolateral prefrontal cortex is a neural correlate and potential biomarker of recovery from a depressed episode.
Psychiatry Research NeuroimagingResting state functional connectivity and treatment response in late-life depression
153 Citations2013Carmen Andreescu, Dana Tudorascu +7 more
The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment, and confirms the central role of white matter lesions in disrupting brain functional connectivity.
Journal of Child Psychology and PsychiatryAberrant resting‐state functional connectivity in limbic and salience networks in treatment‐naïve clinically depressed adolescents
153 Citations2014J. Nienke Pannekoek, Steven J.A. van der Werff +8 more
The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network.
European Journal of RadiologyAltered functional connectivity of the dorsolateral prefrontal cortex in first-episode patients with major depressive disorder
146 Citations2012Ting Ye, Jing Peng +8 more
The study suggested that abnormality of GMD in right DLPFC might be related to the functional connectivity alteration in the pathophysiology of MDD, which might be useful in further characterizing structure-function relations in this disorder.
Neuroscience & Biobehavioral ReviewsIs subcortical–cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach
143 Citations2009Antonio Alcaro, Jaak Panksepp +3 more
A cross-species translational investigation suggests that resting state hyperactivity in depression occurs in subcortical and cortical midline regions and is mediated by glutamate and GABA metabolism.
Psychiatry Research NeuroimagingDefault-mode network connectivity and white matter burden in late-life depression
142 Citations2011Minjie Wu, Carmen Andreescu +4 more
This study provides evidence for altered default-mode network connectivity in late-life depression and the correlation between white-matter hyperintensities burden and default- mode network connectivity emphasizes the role of vascular changes inLate- life depression etiopathogenesis.
Frontiers in Human NeuroscienceAberrant Intrinsic Connectivity of Hippocampus and Amygdala Overlap in the Fronto-Insular and Dorsomedial-Prefrontal Cortex in Major Depressive Disorder
137 Citations2013Masoud Tahmasian, David C. Knight +15 more
The results provide the first evidence of overlapping aberrant HP and AY intrinsic connectivity in MDD, suggesting that aberrant Hewlett-Packard-like connectivity may interact with dysfunctional intrinsic network activity inMDD.
Psychological MedicineLocal cortical thinning links to resting-state disconnectivity in major depressive disorder
131 Citations2013Marie‐José van Tol, Ming Li +9 more
Abnormal cortical thickness in the dorsomedial PFC inMDD patients was observed to selectively and directly affect its intrinsic connectivity with the precuneus in MDD patients independent of depression severity, thereby marking a potential vulnerability for maladaptive mood regulation.
Psychological MedicineDecreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study
123 Citations2012Yanqing Tang, Lingyi Kong +10 more
The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the leftVPFC, which suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.
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