Activity and Connectivity of Brain Mood Regulating Circuit in Depression: A Functional Magnetic Resonance Study
Biological PsychiatryPublished 1 May 2005
Amit Anand, Yu Li, Yang Wang, Jingwei Wu, Sujuan Gao, Lubna Bukhari
Citations791
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic areas is consistent with the hypothesis that decreased cortical regulation of limbics activation in response to negative stimuli may be present in depression.
Abstract
The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.
Keywords
MedicineNeuroscience
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16,817 Citations2002N. Tzourio-Mazoyer, Brigitte Landeau +6 more
An anatomical parcellation of the spatially normalized single-subject high-resolution T1 volume provided by the Montreal Neurological Institute was performed and it is believed that this tool is an improvement for the macroscopical labeling of activated area compared to labeling assessed using the Talairach atlas brain.
Computers and Biomedical ResearchAFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages
11,567 Citations1996Robert W. Cox
A package of computer programs for analysis and visualization of three-dimensional human brain functional magnetic resonance imaging (FMRI) results is described and techniques for automatically generating transformed functional data sets from manually labeled anatomical data sets are described.
Magnetic Resonance in MedicineFunctional connectivity in the motor cortex of resting human brain using echo‐planar mri
10,089 Citations1995Bharat B. Biswal, F. Zerrin Yetkin +2 more
Annual Review of NeuroscienceEmotion Circuits in the Brain
8,385 Citations2000Joseph E. LeDoux
This work has pin- pointed the amygdala as an important component of the system involved in the acqui- sition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala.
Proceedings of the National Academy of SciencesFunctional connectivity in the resting brain: A network analysis of the default mode hypothesis
6,509 Citations2002Michael D. Greicius, Ben Krasnow +2 more
This study constitutes, to the knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network.
NeuroImageFunctional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI
3,490 Citations2002K. Luan Phan, Tor D. Wager +2 more
A critical comparison of findings across individual studies is provided and suggests that separate brain regions are involved in different aspects of emotion.
NatureSubgenual prefrontal cortex abnormalities in mood disorders
2,701 Citations1997Wayne C. Drevets, Joseph L. Price +5 more
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
PubMedBasal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
2,451 Citations1990Garrett E. Alexander, M. D. Crutcher +1 more
American Journal of PsychiatryReciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
2,399 Citations1999Helen S. Mayberg, Mario Liotti +9 more
Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood, suggesting that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions.
Biological PsychiatryNeurobiology of emotion perception I: the neural basis of normal emotion perception
2,147 Citations2003Mary L. Phillips, Wayne C. Drevets +2 more
It is suggested that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems.
Journal of Cerebral Blood Flow & MetabolismFunctional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets
2,010 Citations1993Karl Friston, Chris Frith +2 more
Progress in brain researchChapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions
1,940 Citations1991Garrett E. Alexander, Michael D. Crutcher +1 more
It now appears that at the level of the putamen such inputs remain segregated within the "motor" circuit, and it is difficult to imagine how such functional specificity could be maintained in the absence of strict topographic specificity within the sequential projections that comprise these two circuits.
Proceedings of the National Academy of SciencesHippocampal atrophy in recurrent major depression.
1,923 Citations1996Yvette I. Sheline, P W Wang +3 more
The results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.
Journal of NeuropsychiatryLimbic-cortical dysregulation: a proposed model of depression
1,591 Citations1997Helen S. Mayberg
A working model of depression implicating failure of the coordinated interactions of a distributed network of limbic-cortical pathways is proposed to facilitate continued integration of clinical imaging findings with complementary neuroanatomical, neurochemical, and electrophysiological studies in the investigation of the pathogenesis of affective disorders.
NeuroImageFunctional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State Fluctuations
1,398 Citations1998Mark J. Lowe, B. Mock +1 more
Correlations to left hemisphere motor cortex, visual cortex, and amygdala are measured in long resting-state scans and these correlations are extended to lower sampling rate multislice echoplanar acquisitions and other right/left hemisphere-symmetric functional cortices.
Biological PsychiatryNeuroimaging studies of mood disorders
1,309 Citations2000Wayne C. Drevets
Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders.
Journal of NeuroscienceA functional anatomical study of unipolar depression
1,268 Citations1992W C Drevets, TO Videen +4 more
Evidence suggests that a circuit involving the prefrontal cortex, amygdala, and related parts of the striatum, pallidum, and medial thalamus is involved in the functional neuroanatomy of depression.
Biological PsychiatryIncreased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
1,189 Citations2001Yvette I. Sheline, Deanna M. Barch +4 more
Depressed patients have left amygdala hyperarousal, even when processing stimuli outside conscious awareness, and increased amygdala activation normalizes with antidepressant treatment.
NeuroImageDetecting Activations in PET and fMRI: Levels of Inference and Power
1,157 Citations1996Karl Friston, Andrew P. Holmes +3 more
It is envisaged that set-level inferences will find a role in making statistical inferences about distributed activations, particularly in fMRI.
British Medical BulletinModulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
1,131 Citations2003Helen S. Mayberg
A synthesis of functional neuroimaging studies examining regional metabolic and blood flow changes in depression is presented in the context of a testable limbic-cortical network model, seen as a critical step towards future development of evidenced-based algorithms that will optimize the diagnosis and treatment of individual depressed patients.
Biological PsychiatryRegional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
1,114 Citations2000Helen S. Mayberg, Steven Brannan +5 more
Chronic treatment and clinical response to fluoxetine was associated with a reciprocal pattern of subcortical and limbic decreases and cortical increases, which suggests a process of adaptation in specific brain regions over time in response to sustained serotonin reuptake inhibition.
Biological PsychiatryCan’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
854 Citations2002Greg J. Siegle, Stuart R. Steinhauer +3 more
It is suggested that depression is associated with sustained activity in brain areas responsible for coding emotional features in response to processing negative features of information.
Biological PsychiatryNeocortical modulation of the amygdala response to fearful stimuli
841 Citations2003Ahmad R. Hariri, Venkata S. Mattay +3 more
The current results further implicate the importance of neocortical regions, including the prefrontal and anterior cingulate cortices, in regulating emotional responses mediated by the amygdala through conscious evaluation and appraisal.
NeuroImageLimbic–frontal circuitry in major depression: a path modeling metanalysis
712 Citations2004David A. Seminowicz, Helen S. Mayberg +5 more
The creation of such models is a first step toward full characterization of the depression phenotype at the neural systems level, with implications for the future development of brain-based algorithms to determine optimal treatment selection for individual patients.
Human Brain MappingDetection of functional connectivity using temporal correlations in MR images
693 Citations2002Michelle Hampson, Bradley S. Peterson +3 more
Progress in brain researchFunctional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
659 Citations2000Wayne C. Drevets
Physiological activity is decreased in dorsal PFC areas implicated in language, selective attention, visuospatial or mnemonic processing, but these abnormalities reverse with symptom remission, and may relate to the subtle cognitive impairments associated with MDE.
Biological PsychiatryAn fMRI study of anterior cingulate function in posttraumatic stress disorder
601 Citations2001Lisa M. Shin, Paul J. Whalen +7 more
Findings suggest a diminished response in rostral anterior cingulate cortex in the presence of emotionally relevant stimuli in PTSD, speculate that diminished recruitment of this region in PTSD may, in part, mediate symptoms such as distress and arousal upon exposure to reminders of trauma.
Biological PsychiatryReduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
534 Citations2002Stephen M. Lawrie, Christian Buechel +4 more
Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations and previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements.
American Journal of PsychiatryEvidence for Abnormal Cortical Functional Connectivity During Working Memory in Schizophrenia
510 Citations2001Andreas Meyer‐Lindenberg, Jean-Baptiste Poline +5 more
Pronounced disruptions of distributed cooperative activity in schizophrenia were found and a pattern showing disturbed frontotemporal interactions showed promise as a trait marker and may be useful for future investigations.
Journal of NeuroscienceNetwork analysis of cortical visual pathways mapped with PET
501 Citations1994Anthony R. McIntosh, Cl Grady +4 more
A network analysis was performed on data obtained from a PET study that examined both the changes in regional cerebral blood flow (rCBF) and interregional correlations among human cortical areas during performance of an object vision (face matching) and spatial vision (dot- location matching) task.
Annual Review of MedicineFunctional Neuroimaging Studies of Depression: The Anatomy of Melancholia
500 Citations1998Wayne C. Drevets
Within the anatomical networks implicated in emotional processing by other types of evidence, these BF and metabolic data demonstrate that major depression is associated with reversible, mood state-dependent, neurophysiological abnormalities in some structures and irreversible, trait-like abnormalities in other structures.
American Journal of PsychiatryThe Neural Substrates of Affective Processing in Depressed Patients Treated With Venlafaxine
494 Citations2002Richard J. Davidson, W.J. Irwin +2 more
The findings underscore the importance of the neural circuitry activated by negative affect in depression and indicate that components of this circuitry can be changed within 2 weeks of treatment with antidepressant medication.
NeuroreportAmygdala core nuclei volumes are decreased in recurrent major depression
469 Citations1998Yvette I. Sheline, Mokhtar H. Gado +1 more
The volume loss in this closely related structure suggests a shared effect on both structures, potentially glucocorticoid-induced neurotoxicity mediated by the extensive reciprocal glutamatergic connections.
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323 Citations2005Amit Anand, Yu Li +7 more
The results of this study are consistent with the hypothesis that antidepressant treatment may increase corticolimbic connectivity, thereby possibly increasing the regulatory influence of cortical mood-regulating regions over limbic regions.
NeuroImageCorrelations in Low-Frequency BOLD Fluctuations Reflect Cortico-Cortical Connections
306 Citations2000Mark J. Lowe, Mario Džemidžić +3 more
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American Journal of PsychiatryFunctional MRI Study of the Cognitive Generation of Affect
288 Citations1999John D. Teasdale, Robert Howard +5 more
Activation of these same sites by a range of evoked affects, elicited by different methods, is consistent with areas within the medial prefrontal cortex mediating the processing of affect-related meanings, a process common to many forms of emotion production.
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NeuroreportHuman amygdala activation detected with echo-planar functional magnetic resonance imaging
252 Citations1996W.J. Irwin, Richard J. Davidson +4 more
Findings are consistent with the large corpus of data from non-human studies suggesting that the amygdala is a key structure for extracting the affective significance from external stimuli.
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234 Citations2004Warren D. Taylor, James R. MacFall +5 more
Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects.
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193 Citations2000Konstantinos Arfanakis, Dietmar Cordes +4 more
Functional connectivity, which is demonstrated in the "resting brain," is not affected by tasks which activate unrelated brain regions, and ICA effectively removes activation from the data and may allow us to study functional connectivity even in the activated regions.
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191 Citations2002Israel Liberzon, K. Luan Phan +2 more
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Elsevier eBooksBrain Mapping: The Disorders
158 Citations2000
The study of Human Disease with Brain Mapping Methods and Recent Advances from Brain Imaging Studies, M.J. Mazziotta and R.F. Frackowiak finds that functional neuroimaging studies of Schizophrenia and Psychatric Disorders are increasingly relevant to clinical practice.
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137 Citations1997Mark J. Lowe, James A. Sorenson
It is shown that absolute activation levels are strongly dependent on the parameters of the filter used in image construction and that significance of an activation signal can be enhanced through appropriate filter selection.
Psychological MedicineEffects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task
130 Citations2001Klaas Ε. Stephan, Vincent A. Magnotta +5 more
The findings suggest that olanzapine has a stronger differential effect on neural activity in prefrontal cortex and thalamus than in motor structures, which may indicate repetition effects rather than drug effects.
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103 Citations2000John Burruss, Robin A. Hurley +4 more
The current theories regarding the locations and functions of the three primary frontal lobe circuits form the framework for structuring functional magnetic resonance imaging investigations and can be used to assist in detecting subtle lesions of the frontal circuits.
Seminars in Clinical NeuropsychiatryModulating limbic-cortical circuits in depression: Targets of antidepressant treatments
102 Citations2002Helen S. Mayberg
A cortical-limbic network model of depression is used and network dysfunction combined with ongoing intrinsic compensatory processes is seen to explain the heterogeneity of depressive symptoms observed clinically, as well as variations in pretreatment scan patterns.
American Journal of PsychiatryFunctional Magnetic Resonance Imaging Evidence for Disrupted Basal Ganglia Function in Schizophrenia
101 Citations2001Vinod Menon, Robert Anagnoson +2 more
PubMedClinical significance of reversed vegetative subtypes of recurrent major depression.
97 Citations1991Michael E. Thase, Linda L. Carpenter +2 more
There were few differences between reversed vegetative AD patients with reactive and nonreactive moods; both subforms of AD responded well to monoamine oxidase inhibitor when crossed over after initial protocol treatment failed.
The NeuroscientistFunctional Brain Imaging, Limbic Function, and Affective Disorders
97 Citations1996Terence A. Ketter, Mark S. George +3 more
New imaging methods with greater sensitivity, spatial and temporal resolution, and biochemical specificity promise to fuel further insights into the neurobiology of normal emotion in health, subtypes of affective disorders, and perhaps even improved targeting of therapeutic interventions.
The NeuroscientistThe Human Amygdala and Emotion
91 Citations1999Ralph Adolphs
Lesion and functional imaging studies in humans support a role for the amygdala in recognizing emotions in facial expressions, especially fear, and shows that the amygdala also modulates encoding of declarative knowledge about emo tional material.
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87 Citations2002J. Douglas Bremner
Findings of an increase in white matter lesions in elderly patients with depression have been replicated and correlated with late-onset depression, as well as impairments in social and cognitive function, point to alterations in a circuit of brain regions hypothesized to include the frontal cortex, hippocampus, amygdala, striatum, and thalamus that underlie symptoms of depression.
Psychiatrische Praxis. SupplementfMRI an der Forensischen Klinik am Bezirksklinikum Regensburg - Neuroanatomische Grundlagen der Emotionsverarbeitung
78 Citations2004Johannes Schwerdtner, Monika Sommer +2 more
Structural-morphological neural areas of emotion regulation in "psychopathy" show variant activation patterns in fMRI, suggesting the neural basis of emotional impairment could be a dysfunctional medial prefrontal cortex and amygdala.
Magnetic Resonance in MedicineOptimized distortion correction technique for echo planar imaging
77 Citations2001Nan‐kuei Chen, Alice M. Wyrwicz
A new phase‐shifted EPI pulse sequence is described that encodes EPI phase errors due to all off‐resonance factors, including Bo field inhomogeneity, eddy current effects, and gradient waveform imperfections, which can be used to effectively remove geometric distortions in subsequent EPI scans.
American Journal of PsychiatryFunctional Imaging Studies: Linking Mind and Basic Neuroscience
70 Citations2001Robert G. Shulman
The results show that in the awake, resting, and unstimulated states, 70%-80% of brain energy consumption is devoted to the same glutamate/glutamine neurotransmitter signaling as are the small percentages stimulated by tasks.
CNS SpectrumsA European Perspective on Depression in the Community: The DEPRES Study
14 Citations2002S. Arbabzadeh‐Bouchez, André Tylee +1 more
A pan-European study aimed at assessing the extent and consequences of depression in six different countries is reported in this article.
Functional Connectivity MR Imaging
9 Citations2011Michelle Hampson, Xilin Shen +1 more
This chapter is focused on the methods and applications of functional connectivity analyses, defined as “temporal correlations between spatially remote neurophysiological events”.
