Aminocatalytic Enantioselective <i>anti‐</i>Mannich Reaction of Aldehydes with In Situ Generated <i>N</i>‐Cbz and <i>N</i>‐Boc Imines
Angewandte ChemiePublished 7 October 2008
Chiara Gianelli, Letizia Sambri, Armando Carlone, Giuseppe Bartoli, Paolo Melchiorre
Citations38
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Abstract
Die Titelreaktion, die durch das kommerziell erhältliche chirale sekundäre Amin 1 katalysiert wird, überführt die stabilen α-Amidosulfone 2 in situ hoch stereoselektiv in N-Carbamat-geschützte Imine. Dieser organokatalytische Ansatz bietet einen bequemen Zugang zu den wertvollen Produkten 3, die in hohen Ausbeuten mit sehr guter anti-Selektivität und hoher Enantiomerenreinheit erhalten werden.
Keywords
Chemistry
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