Expression of the p53 oncogene in acute myeloblastic leukemia.
The Journal of Experimental MedicinePublished 1 September 1986Open access
Lachlan J. Smith, E. A. McCulloch, Samuel Benchimol
Citations52
SJR quartileQ1
SJR score5.83
SNIP1.99
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TL;DR
A highly significant correlation between p53 protein synthesis in leukemic blast cells and the secondary plating efficiency of these cells is found, which provides an estimate for the self renewal capacity of progenitor cells in the blast population.
Abstract
We have investigated whether the p53 oncogene is expressed in the blast cells of patients with acute myeloblastic leukemia. p53 protein was detected in the blast cells of 19 out of 34 patients, but not in normal myelopoietic cells. We find a highly significant correlation between p53 protein synthesis in leukemic blast cells and the secondary plating efficiency of these cells (p = 0.0001). The latter provides an estimate for the self renewal capacity of progenitor cells in the blast population. These data indicate that p53 may be involved in leukemic stem cell renewal.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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