Epidemiology of hepatitis C virus infection among injection drug users in China: Systematic review and meta-analysis
Public HealthPublished 20 May 2008
Xian Xia, Jun Luo, Jianling Bai, Rongbin Yu
Citations164
SJR quartileQ1
SJR score1.22
SNIP1.12
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TL;DR
IDU continues to fuel the HCV/HIV epidemics spreading throughout China, with high-risk sexual practices were strongly associated with drug injection behaviours and a longer duration of IDU was associated with increased HCV prevalence.
Abstract
IDU continues to fuel the HCV/HIV epidemics spreading throughout China. Many pragmatic strategies are being implemented but need further evaluation.
Keywords
Medicine
BMJBias in meta-analysis detected by a simple, graphical test
56,268 Citations1997Matthias Egger, George Davey Smith +2 more
Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
JAMAMeta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
20,682 Citations2000Donna F. Stroup
A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Medical Entomology and ZoologyThe Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses
17,869 Citations2014George A. Wells
The goal of this project is to develop an instrument providing an easy and convenient tool for quality assessment of nonrandomised studies to be used in a systematic review.
The Lancet Infectious DiseasesGlobal epidemiology of hepatitis C virus infection
2,741 Citations2005Colin W. Shepard, Lyn Finelli +1 more
Because there is no vaccine and no post-exposure prophylaxis for HCV, the focus of primary prevention efforts should be safer blood supply in the developing world, safe injection practices in health care and other settings, and decreasing the number of people who initiate injection drug use.
HepatologyLiver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients
1,221 Citations1999Yves Benhamou, Marie Bochet +9 more
In coinfected patients, a low CD4 count, alcohol consumption rate, and age at HCV infection are associated with a higher liver fibrosis progression rate, while HIV seropositivity accelerates HCV‐related liver Fibrosis progression.
Clinical Infectious DiseasesInfluence of Human Immunodeficiency Virus Infection on the Course of Hepatitis C Virus Infection: A Meta‐Analysis
966 Citations2001Camilla S. Graham, Lindsey R. Baden +5 more
There is a significantly elevated RR of severe liver disease in persons who are coinfecting with HIV and HCV, which has important implications for timely diagnosis and consideration of treatment in coinfected persons.
The LancetClinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study
901 Citations2000Gilbert Greub, B Ledergerber +13 more
Hematitis C virus and active intravenous drug use could be important factors in the morbidity and mortality among HIV-1-infected patients, possibly through impaired CD4-cell recovery in HCV seropositive patients receiving potent antiretroviral therapy.
American Journal of Public HealthViral infections in short-term injection drug users: the prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses.
705 Citations1996Richard S. Garfein, David Vlahov +3 more
The high rates of HCV, HBV, and HIV infections among short-term injectors emphasizes the need to target both parenteral and sexual risk reduction interventions early, and renewed efforts at primary prevention of substance abuse are indicated.
International Journal of Technology Assessment in Health CareSome Statistical Methods for Combining Experimental Results
573 Citations1990Nan M. Laird, Frederick Mosteller
The steps an assessor might take in combining data from different studies are delineated and references are provided to provide references for topics not discussed in detail.
American Journal of Public HealthSharing of drug preparation equipment as a risk factor for hepatitis C
500 Citations2001Holly Hagan, Hanne Thiede +4 more
American Journal of EpidemiologyRisk of Hepatitis C Virus Infection among Young Adult Injection Drug Users Who Share Injection Equipment
446 Citations2002Lorna E. Thorpe
It is concluded that sharing of injection equipment other than syringe-sharing may be an important cause of HCV transmission between IDUs.
AIDSOverland heroin trafficking routes and HIV-1 spread in south and south-east Asia
375 Citations2000Chris Beyrer, Myat Htoo Razak +4 more
Overland heroin export routes have been associated with dual epidemics of injecting drug use and HIV infection in three Asian countries and along four routes, indicating that single country narcotics and HIV programs are unlikely to succeed unless the regional narcotic-based economy is addressed.
International Journal of Medical SciencesEpidemiology of Hepatitis C Virus (HCV) Infection
362 Citations2006Theodore Sy, M. Mazen Jamal
Current hepatitis C virus prevalence and genotype data are reviewed and the different risk factors associated with the virus are examined and the current risk factors are examined.
HepatologyLiver disease in Egypt: Hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors
270 Citations2006G. Thomas Strickland
Efforts have been initiated by the Egyptian MOH to prevent new infections and complications of HCV in the estimated 6 million infected persons.
CancerPredictors of local recurrence after treatment of ductal carcinoma in situ
266 Citations1999John Boyages, Geoff P. Delaney +1 more
The authors reviewed the published studies and identified the factors that may be predictive of local recurrence after management by mastectomy, CS alone, or CS + RT.
Journal of Clinical MicrobiologyIncidence and risk factors for hepatitis C among injection drug users in Baltimore, Maryland
226 Citations1997Stephen Villano, David Vlahov +4 more
Efforts to reduce HCV infection must be focused on curbing drug use and especially on the sharing of needles and drug paraphernalia, according to participants who acknowledged active drug use.
International Journal of EpidemiologyRapid transmission of hepatitis C virus among young injecting heroin users in Southern China
161 Citations2004Rebecca Garten
HCV infection is rapidly acquired in heroin users who adopt injection in southern China and this study emphasizes the urgent need to implement and expand injection prevention and primary substance abuse prevention programmes in China.
The Medical Journal of AustraliaIncidence of bloodborne virus infection and risk behaviours in a cohort of injecting drug users in Victoria, 1990‐1995
137 Citations1997Nick Crofts, Campbell Aitken
To assess changes in risk behaviours for transmission of bloodborne viruses and incidences and prevalences of these viruses in a field‐recruited cohort of injecting drug users, a large number of patients were recruited.
Harm Reduction JournalInjection drug use and HIV/AIDS in China: Review of current situation, prevention and policy implications
128 Citations2006Han‐Zhu Qian, Joseph E. Schumacher +2 more
Strengthening government leadership at both central and local levels; scaling up methadone substitution and needle exchange programs; making HIV voluntary counseling and testing available and affordable to both urban and rural drug users; and increasing utilization of outreach and nongovernmental organizations are offered as additional strategies to help cope with China's HIV and drug abuse problem.
AIDS and BehaviorPotential Bridges for HIV Infection to Men Who Have Sex With Men in Guangzhou, China
113 Citations2006Qun He, Ye Wang +11 more
The currently low prevalence of HIV but high level of unprotected anal sex, high prevalence of syphilis infection, and sexual networks that include foreign MSM point to a transient window for HIV prevention among MSM in Guangzhou.
The Journal of Infectious DiseasesDeterminants of the Quantity of Hepatitis C Virus RNA
112 Citations2000David L. Thomas, Jacquie Astemborski +8 more
To test the hypothesis that person-to-person variability in blood levels of hepatitis C virus (HCV) RNA can be explained, the quantity of HCV RNA was assessed in 969 persons who acquired HCV infection in the context of injection drug use.
PubMedChronic hepatitis C: an age wave of disease burden.
109 Citations2005John G. McHutchison, Bruce R. Bacon
Although it is difficult to predict which HCV-infected patients will progress to serious liver disease, the availability of a combination drug regimen that essentially "cures" the disease in more than half of treated patients now provides clinicians and pharmacists in managed care settings with the tools needed to diminish the impact of the anticipated wave of liver disease.
Clinical Infectious DiseasesCoinfection with HIV and Hepatitis C Virus among Injection Drug Users in Southern China
88 Citations2005Rebecca Garten, Jinbing Zhang +4 more
Sexual activity during the past 6 months and duration of injection drug use were significantly associated with coinfection with HIV and HCV, and molecular tracking of HCV may be a more sensitive predictor of the future spread of the HIV-1 epidemic than is HIV subtyping.
Cell ResearchInjection drug use and HIV/AIDS transmission in China
84 Citations2005Tian Xin CHU, Judith A. Levy
An overview to HIV/AIDS transmission through injection drug use in China is provided, followed by a discussion of the emergence of drug related AIDS, and a profile of drug users and their sexual partners who have contracted the virus or who are vulnerable to infection.
Sexually Transmitted InfectionsHepatitis C virus infection in a large cohort of homosexually active men: independent associations with HIV-1 infection and injecting drug use but not sexual behaviour.
82 Citations1996Neil Bodsworth, Philip Cunningham +2 more
IDU was the major behavioural risk factor for HCV infection and its association with human immunodeficiency virus type 1 (HIV-1) infection and other STDs, number of sexual partners, sexual practices and recreational drug use.
BMJHIV and hepatitis C among injecting drug users
75 Citations1998R A Coutinho
It is reported that among young injecting drug users in Sydney the incidence of HIV infection in 1992-5 was only 0.2 per 100 person years, while the incidence with hepatitis C virus was extremely high; among those aged under 20 the rate was 76 per100 person years.
Journal of Gastroenterology and HepatologyR<scp>eview:</scp> Molecular epidemiology of hepatitis C virus
73 Citations1997Donald B. Smith, Peter Simmonds
AddictionThe second National Epidemiological Survey on illicit drug use at six high‐prevalence areas in China: prevalence rates and use patterns
62 Citations2002Wei Hao, Shuiyuan Xiao +8 more
Compared with the data from the 1993 survey, illicit drug use has continued to escalate across the areas, calling for priority concern in various sections of the country.
Journal of Psychoactive DrugsA Potential Hidden Source of Hepatitis C Infection Among Noninjecting Drug Users
61 Citations2003James M. McMahon, Stephanie Tortu
Current biological evidence does not refute either oral or intranasal transmission as possible sources of HCV infection, although more research is needed in the areas of oronasal HCV pathogenesis and the detection ofHCV RNA in the nasal mucosa of intranAsal drug users.
PubMedHepatitis C virus infections and genotypes in China.
60 Citations2002Chen Yuan‐ding, Mingying Liu +6 more
China has a high incidence of HCV infection and the results will provide a strategic basis for diagnosis, treatment and possibly prophylaxis of hepatitis C virus diseases.
Substance Use & MisuseREAWAKENING THE DRAGON: CHANGING PATTERNS OF OPIATE USE IN ASIA, WITH PARTICULAR EMPHASIS ON CHINA'S YUNNAN PROVINCE
57 Citations2001Clyde B. McCoy, H. Virginia McCoy +4 more
Data collected between August 1997 and February 1998 indicate injecting heroin users, in comparison to noninjectors, were more likely to have used drugs for a longer period of time, and to use drugs more frequently everyday.
AddictionLongitudinal surveys of prevalence rates and use patterns of illicit drugs at selected high‐prevalence areas in China from 1993 to 2000
55 Citations2004Wei Hao, Zhonghua Su +5 more
At least for the time being, illicit drug use may have plateaued in these selected high-prevalence areas in China, and the prevalence patterns of illicit drug are described.
World Journal of GastroenterologyCommunity-based survey of HCV and HIV coinfection in injection drug abusers in Sichuan Province of China
42 Citations2004Yuhua Ruan
Shared needles and syringes in the past 3 mo and syphilis infection were significantly associated with HCV infection, and no statistically significant association was found in univariate analysis between sexual behaviors and HCV/HIV coinfection.
HepatologyEffect of Duration of Hepatitis B Virus Infection on the Association Between Human Immunodeficiency Virus Type–1 and Hepatitis B Viral Replication
41 Citations1992Beryl A. Koblin, Patricia E. Taylor +2 more
Hepatitis B virus replication among chronic carriers may be a function of duration of hepatitis B virus infection rather than of an effect of human immunodeficiency virus type‐1.
Drug and Alcohol DependenceHIV sexual risk behaviors among injection drug users in Shanghai
39 Citations2006Min Zhao, Jiang Du +5 more
Sexual risk behaviors among IDUs in Shanghai are common, and many IDUs are vulnerable for transmission of disease, so prevention efforts with IDUs should address sexual risk behaviors in addition to needle-sharing behaviors.
PubMedHigh prevalence of hepatitis C virus infection in Belgian intravenous drug users and potential role of the "cotton-filter" in transmission: the GEMT Study.
26 Citations2000Baudouin Denis, Martine Dedobbeleer +5 more
HCV seroprevalence is very high among belgian IVDU and prevention strategies have to focus on neophytes injectors, and follow-up and treatment of chronic hepatitis C seem to be poorly effective among drug users.
Journal of Urban HealthRisk Behaviors and HIV/AIDS Prevention Education Among IDUs in Drug Treatment in Shanghai
20 Citations2005Meiping Zhao
It was found that risk behaviors, including unsafe sex and unclean injection practices, were common among the subjects and HIV/AIDS prevention education increased HIV knowledge, improved understanding of HIV prevention methods and changed attitudes toward HIV/ AIDS.
PubMed[Prevalence of HIV and HCV among injecting drug users (IDUs) in Yunnan, China].
12 Citations1994Dawei Li, Xinyu Zheng +1 more
The results reveal that sharing needles with other IDUs is one of the primary pathways to transmit both HIV andHCV, and it is suggested that all IDUs should be encouraged to stop using drugs to prevent HIV and HCV transmission.
PubMed[Study on the relationship between hepatitis C virus infection and sharing injection equipment, sexual behavior among injecting drug users].
7 Citations2004Feng Zhou, Ze-en Ma +11 more
Data from multivariate logistic regression showed that sharing of needles or syringes and history of syphilis infection were significantly associated with HCV transmission, and no significant difference was found between HCV infection and sexual behavior after univariate analysis using chi-square test.
ANALYSIS OF HCV INFECTION AMONG 1000 HEROIN ADDICTS
2 Citations2003XU Benshu
Intravenous injecting drug use is the main factor of HCV infections among drug abusers and it is important to prevent and intervene in risk behaviors such as iv drug use, sharing injectors amongdrug abusers.
The Analysis of HCV Infection in 327 Heroin Addicts
2 Citations2005Wei Xiaohua
HCV infection was positively related with drug-taking pattern and duration of injection, and ALT abnormalities were significantly correlated with HCV infection.
Xiandai yufang yixueA STUDY ON INFECTION OF HCV AMONG DRUG USERS,PERSONS WITH SEX RELATED CRIMES AND ERRORS AND GENERAL POPULATION.
2 Citations1999WU Caiyang
It is concluded that the infection of HCV is highly epidemic in drug users and lower epidemic in persons with sex related crimes and errors.
Zhongguo yaowu yilaixing zazhiEPIDEMIOLOGICAL SURVEY OF HEROIN ADDICTS INFECTED BY HCV AND HBV
2 Citations2000Lijun Sha
Intravenous drug use is the relative factor of HCV infection among heroin addicts and it is important to reduce iv drug use and prevent sharing injectors.
Zhongguo redai yixueInvestigation into the relationship between the high risk behavior of drug abusing population and HCV infection
2 Citations2006Hu Wei
HCV and HIV prevalence was high among drug users in Xichang County of Sichuan Province and intervention on the bahevior of direct and indirect sharing injection equipments among drug Users be strengthened.
Practical Preventive MedicineEpidemiological Survey of Four Blood Transmitting Infections Among Injection Drug Takers in Yueyang City
2 Citations2006Huahong Wang
The infection rates of HCV and HIV are high and intravenous use of drug and share of the same syringe and needle are the high risk factors.
Chinese Journal of Disease Control and PreventionStudy of hepatitis C virus infection rate and its risk factors among injecting drug users in Beijing, China
2 Citations2006Guodong Mi, Std Control
The infection rate of HCV was 52.59% among injecting drug users in Beijing, which showed that HIV risk behaviors were popular among these population.
Zhonghua jianyan yixue zazhiThe study of HCV and HIV infections among heroin addicts
2 Citations2003Wang Sheng-q
IDU was one of the highest risk factors for infection HCV and HIV in heroin addicts and the prevalence of coinfections HCv and HIV was significantly higher in IDU than in nIDU, and anti-NS 5 of HCV was significantly associated with HCV-RNA.
ANALYSIS OF HAV, HBV AND HCV INFECTION IN 386 HEROIN ADDICTS
1 Citations2002Yanfen Wang
Heroin abuse by iv can cause high infection rates of HBV and HCV, and there was no significant difference between im mixed with chasing group and chasing only group.
Practical Preventive MedicineAN Analysis of HCV Infection and ALT Alteration in Intravenous Drug Addicts in Zhanjiang City
1 Citations2004Jialin Chen
The high rates of HCV infection and ALT alteration may come from sharing injector and solvent for drugs, and drug andHCV infection can result inALT alteration.
Jibing jianceInfection of Diseases Transmitted Through Blood of Venous Drug Addicts
1 Citations2004Zu-mu Zhou
The venous drug addicts were high-risk population for diseases transmitted through blood, several diseases could come together or overlap one another for these people, and joint use of non-disinfected syringe could bring cross infection.
