Do polycystic-appearing ovaries affect the risk of cardiovascular disease among women with polycystic ovary syndrome?
Fertility and SterilityPublished 1 September 2000Open access
Tammy L. Loucks, Evelyn O. Talbott, Kathleen P. McHugh, Michael H. Keelan, Sarah L. Berga, David S. Guzick
Citations68
SJR quartileQ1
SJR score2.03
SNIP2.05
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Women with PCOS have greater cardiovascular risk than controls, however, the ultrasound appearance of polycystic ovaries does not appear to further intensify the cardiovascular disease risk profile of these women.
Abstract
Women with PCOS have greater cardiovascular risk than controls. Within PCOS cases, however, the ultrasound appearance of polycystic ovaries does not appear to further intensify the cardiovascular disease risk profile of these women.
Keywords
Medicine
The Journal of Clinical Endocrinology & MetabolismPrevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women<sup>1</sup>
1,533 Citations1999Richard S. Legro, Allen R. Kunselman +2 more
PCOS women are at significantly increased risk for IGT and type 2 diabetes mellitus at all weights and at a young age; these prevalence rates are similar in 2 different populations of PCOS women, suggesting that PCOS may be a more important risk factor than ethnicity or race for glucose intolerance in young women.
The Journal of Clinical Endocrinology & MetabolismPrevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study<sup>1</sup>
1,519 Citations1998Eric S. Knochenhauer, Timothy J. Key +4 more
Diabetes CarePrevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
1,263 Citations1999David A. Ehrmann, Randall B. Barnes +3 more
It is concluded that women with PCOS should periodically have an OGTT and must be closely monitored for deterioration in glucose tolerance, particularly among those with IGT, the subgroup at highest risk for subsequent development of NIDDM.
BMJPrevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.
994 Citations1986Judith Adams, D. W. POLSON +1 more
It is shown that polycystic ovaries, as defined by pelvic ultrasound, are very common in anovulatory women and are not necessarily associated with hirsutism or a raised serum luteinising hormone concentration.
The LancetPOLYCYSTIC OVARIES—A COMMON FINDING IN NORMAL WOMEN
916 Citations1988D. W. POLSON, J Wadsworth +2 more
The prevalence of polycystic ovaries (PCO) in normal women of reproductive age was determined by pelvic ultrasound scanning of 257 volunteers who considered themselves to be normal and who had not sought treatment for menstrual disturbances, infertility, or hirsutism, which suggest that PCO in women who consider themselves toBe normal is part of the same clinical spectrum as the classic Stein-Leventhal syndrome.
Journal of Clinical EpidemiologyMortality of Women with Polycystic Ovary Syndrome at Long-term Follow-up
509 Citations1998T. Pierpoint, Paul McKeigue +3 more
It is concluded that women with polycystic ovary syndrome do not have markedly higher than average mortality from circulatory disease, even though the condition is strongly associated with diabetes, lipid abnormalities, and other cardiovascular risk factors.
Arteriosclerosis Thrombosis and Vascular BiologyCoronary Heart Disease Risk Factors in Women With Polycystic Ovary Syndrome
502 Citations1995Evelyn O. Talbott, David S. Guzick +5 more
Women with PCOS had significantly increased cardiovascular disease risk factors compared with control women, including increases in body mass index, insulin, and triglyceride levels, and increased total cholesterol and fasting LDL levels, waist/hip ratio, and systolic blood pressure.
Clinical EndocrinologyRisk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome
427 Citations1992Gerard S. Conway, Rajendra Agrawal +2 more
This work has focused on three cardiac risk factors which have been associated with hyperinsullnaemia by measuring glucose tolerance, fasting serum lipid concentrations and blood pressure in women with PCOS.
Annals of Internal MedicineAssociation between Polycystic Ovaries and Extent of Coronary Artery Disease in Women Having Cardiac Catheterization
330 Citations1997Mary Birdsall, Cynthia M. Farquhar +1 more
Whether women with more extensive coronary artery disease (as seen on coronary angiography) are more likely to have polycystic ovaries appearing on ultrasonography than are women with less extensive coronary disease is sought.
Journal of Clinical EpidemiologyAdverse Lipid and Coronary Heart Disease Risk Profiles in Young Women with Polycystic Ovary Syndrome: Results of a Case-Control Study
310 Citations1998Evelyn O. Talbott, Annette Clerici +6 more
Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels after controlling for the other variables.
Polycystic Ovary Syndrome
262 Citations2002R. Jeffrey Chang, Jerrold J. Heindel +1 more
Polycystic ovary syndrome is a reproductive-metabolic disorder that is the most common endocrinopathy of women in their reproductive years of life and there is a familial inheritance pattern and long-term health concerns include an increased risk for uterine and cancer cardiovascular disease.
The American Journal of MedicineHyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus
239 Citations1995Andrea Dunaif
Evidence suggests that women with polycystic ovary syndrome have a unique disorder of insulin action and are at increased risk to develop non-insulin-dependent diabetes mellitus.
American Journal of Obstetrics and GynecologyCarotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study
214 Citations1996David S. Guzick, Evelyn O. Talbott +4 more
It is suggested that women with polycystic ovary syndrome have an increased risk of subclinical atherosclerosis in their 40s.
Fertility and SterilityClassification of normogonadotropic infertility: polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome
193 Citations1997Evert J. P. van Santbrink, Wim C.J. Hop +1 more
In the study group of normogonadotropic oligomenorrhea or amenorrheic infertile women, strict cutoff levels for various criteria used in the literature for defining PCOS were set, but sonographic parameters had limited predictive value for abnormal hormone serum levels.
Fertility and SterilitySerum testosterone levels decrease in middle age in women with the polycystic ovary syndrome
177 Citations2000Stephen J. Winters, Evelyn O. Talbott +3 more
Testosterone levels were increased in younger and older women with PCOS compared with controls but were similar to controls in women 42–47 years of age, and may contribute to their increased risk for cardiovascular disease, endometrial cancer, and other diseases.
Seminars in Reproductive MedicineDiagnostic Criteria in Polycystic Ovary Syndrome
136 Citations2003Richard S. Legro
Both consensus and the preliminary evidence-based trials support a combination of hyperandrogenemia and oligo-ovulation, in the absence of known causes, as diagnostic criteria, but there are also strong proponents of using ovarian morphology to identify and diagnose the syndrome.
Fertility and SterilityAssociation between ovarian changes assessed by transvaginal sonography and clinical and endocrine signs of the polycystic ovary syndrome
114 Citations1993Thierry D. Pache, Frank H. de Jong +2 more
Although immunoreactive LH and bioactive LH correlated with all ovarian parameters, the effect of androgens on ovarian changes appeared to be independent from LH, which further substantiates the apparent cardinal role of androgen in the genesis of polycystic ovaries.
Human ReproductionEndocrine abnormalities in ovulatory women with polycystic ovaries on ultrasound
103 Citations1997Enrico Carmina, L-J C Wong +5 more
It appears that a disturbance of the IGF/IGFBP-1 axis is common and apparently closely associated with alterations in ovarian morphology, and up to a third of ovulatory women with PAO/PCO may be uncovered.
Fertility and SterilityDo hyperandrogenic women with normal menses have polycystic ovary syndrome?
98 Citations1999Enrico Carmina, Rogerio A. Løbo
It is suggested that most hyperandrogenic women who report normal menses have evidence for the diagnosis of PCOS, suggesting both the anovulatory and ovulatory patients studied could have PCOS.
Human ReproductionEndocrinology: Subjects with polycystic ovaries without hyperandrogenaemia exhibit similar disturbances in insulin and lipid profiles as those with polycystic ovary syndrome
85 Citations1995Robert J. Norman, William M. Hague +2 more
Ultrasound evidence for PCO predicts similar metabolic sequelae to PCOS and can therefore be used for studies of the genetics and long term risks for this condition.
Obstetrical & Gynecological SurveyPrevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome
71 Citations1999Richard S. Legro, Allen R. Kunselman +2 more
Obstetrical & Gynecological SurveyRisk Factors for Coronary Artery Disease in Lean and Obese Women With Polycystic Ovary Syndrome
61 Citations1993G Conway, R.P. Agrawal +2 more
Clinical EndocrinologyPolycystic ovaries in pre and post‐menopausal women
57 Citations1996Mary Birdsall, Cindy Farquhar
Baillière s Clinical Obstetrics and Gynaecology8 Definition and significance of polycystic ovaries
42 Citations1997Didier Dewailly
The aim of this review is to present the diagnostic dilemma in the diagnosis of PCOS and to discuss the prognostic significance of the PCO.
Seminars in Reproductive MedicineMetabolic Aspects of Polycystic Ovary Syndrome
27 Citations1997Robert A. Wild
The metabolic aberrations in patients with polycystic ovary syndrome (PCOS) demand a shift in clinical care from symptom driven to the prevention of chronic disease.
MedicinePolycystic ovary syndrome
20 Citations2009Stephen Franks
Management of PCOS includes treatment of infertility, menstrual regulation in women who do not desire pregnancy and treatment of associated symptoms of hyperandrogenism, and the introduction of diet and lifestyle changes for overweight and obese women with PCOS, which improves fertility and helps prevent the possible long-term consequences of the metabolic disturbance characteristic of anovulatory women withPCOS.
Ultrasound in Obstetrics and GynecologyOvarian morphology as a predictor of hormonal values in polycystic ovary syndrome
17 Citations1996S. Van der Westhuizen, Zephne M. van der Spuy
The objective of this investigation was to correlate the severity of ultrasound abnormality in the ovaries of women suspected of having the polycystic ovary syndrome with their endocrinopathy in an attempt to establish which anatomical abnormalities best predict endocrine dysfunction.