Antibiotics for acute maxillary sinusitis
Cochrane Database of Systematic ReviewsPublished 21 April 2008
Anneli Ahovuo-Saloranta, Ulla-Maija Rautakorpi, Oleg Borisenko, Helena Liira, John W Williams, Marjukka Mākelä
Citations240
SJR quartileQ1
SJR score1.62
SNIP2.04
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TL;DR
Antibiotics have a small treatment effect in patients with uncomplicated acute sinusitis in a primary care setting with symptoms for more than seven days, and Clinicians need to weigh the small benefits of antibiotic treatment against the potential for adverse effects at both the individual and general population level.
Abstract
Antibiotics have a small treatment effect in patients with uncomplicated acute sinusitis in a primary care setting with symptoms for more than seven days. However, 80% of participants treated without antibiotics improve within two weeks. Clinicians need to weigh the small benefits of antibiotic treatment against the potential for adverse effects at both the individual and general population level.
Keywords
Medicine
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Scandinavian Journal of Infectious DiseasesEvaluation of the Antibiotic Effect of Treatment of Maxillary Sinusitis
40 Citations1975Christer Carenfelt, C.‐M. Eneroth +2 more
Bacterial survival in the maxillary sinus despite a high antibiotic concentration in the sinus illustrates that MIC values determined in the laboratory do not always mirror the sensitivity of bacteria to antibiotics in vivo.
Clinical TherapeuticsA multicenter, randomized, investigator-blinded study of 5- and 10-day gatifloxacin versus 10-day amoxicillin/clavulanate in patients with acute bacterial sinusitis
39 Citations2002Lawrence Sher, Michael A. McAdoo +4 more
In this population of patients with acute, uncomplicated sinusitis of presumed bacterial origin, a short course (5 days) of gatifloxacin therapy was associated with comparable clinical cure rates and tolerability to those of standard 10-day therapy with gat ifloxAcin or amoxicillin/clavulanate.
Journal of General Internal MedicineMeasures of health-related quality of life for adults with acute sinusitis
39 Citations2003Jeffrey A. Linder, Daniel E. Singer +2 more
A lack of valid, responsive outcome measures may limit current treatment recommendations for patients with acute sinusitis and a few validated measures of sinuitis-specific HRQL are available.
Ear Nose & Throat JournalEfficacy of Clarithromycin vs. Amoxicillin/Clavulanate in the Treatment of Acute Maxillary Sinusitis
39 Citations1993Jacques Dubois, C Saint-Pierre +1 more
It is concluded that clarithromycin appears to be as effective as amoxicillin/clavulanate in acute maxillary sinusitis and may cause fewer gastrointestinal upsets.
Ear Nose & Throat JournalLoracarbef (LY163892) vs Amoxicillin/Clavulanate in Bacterial Maxillary Sinusitis
38 Citations1992Thomas Austin Sydnor, W. Michael Scheld +4 more
Loracarbef was comparable in efficacy to amoxicillin/clavulanate with a more desirable safety profile and was compared with am toxicillin/ clavulAnate potassium in a 10-day, single-blind, randomized parallel trial in the treatment of acute bacterial maxillary sinusitis.
Current Medical Research and OpinionComparative efficacy and tolerability of clarithromycin and amoxycillin in the treatment of out-patients with acute maxillary sinusitis
37 Citations1990Evaldo Marchi
Clarithromycin was comparable to amoxycillin with respect to clinical efficacy and tolerability and offers a useful addition to the available therapies for the treatment of acute maxillary sinusitis.
International Journal of Clinical PracticeMOXIFLOXACIN VERSUS AMOXYCILLIN CLAVULANATE IN THE TREATMENT OF ACUTE MAXILLARY SINUSITIS: A PRIMARY CARE EXPERIENCE
36 Citations2001S Rakkar, K Roberts +4 more
Family PracticeMaxillary sinusitis in adults: an evaluation of placebo-controlled double-blind trials
35 Citations1997W.A.B. Stalman
The effectiveness of antibiotic treatment in acute maxillary sinusitis in a general practice population is not based sufficiently on evidence.
International Journal of Immunopathology and PharmacologyA Therapeutic Approach in the Treatment of Infections of the Upper Airways: Thiamphenicol Glycinate Acetylcysteinate in Sequential Treatment (Systemic-Inhalatory Route)
34 Citations2007Agostino Serra, Gian Carlo Schito +2 more
Eight hundred and seventeen patients with upper respiratory tract infections were treated with thiamphenicol glycinate acetylcisteinate (TGA) or other standard antibiotics for 6–10 days in a randomised trial, and none of the isolated bacteria proved to be resistant to TGA.
Annals of Otology Rhinology & LaryngologyDouble-Blind Comparative Trial of Ciprofloxacin versus Clarithromycin in the Treatment of Acute Bacterial Sinusitis
34 Citations1999Kevin M. A. Clifford, Robert Tosiello +5 more
The combined end of therapy and follow-up clinical evaluation analyses revealed that CIP and CLARI were equally effective in the management of acute sinusitis, although twice as many relapses were reported among CLARI recipients.
American Journal of OtolaryngologyAzithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis
33 Citations1999Ivica Klapan, Josip Čulig +3 more
In adults with acute sinusitis, a 3- day course of azithromycin was as effective and well tolerated as a 10-day course of amoxicillin/clavulanic acid.
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