A Systematic Evaluation of the Effect of Temperature on Coagulation Enzyme Activity and Platelet Function
The Journal of Trauma: Injury, Infection, and Critical CarePublished 1 June 2004
Alisa S. Wolberg, Zhi Hong Meng, Dougald M. Monroe, Maureane Hoffman
Citations519
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TL;DR
The results suggest that bleeding observed at mildly reduced temperatures (33 degrees - 37 degrees C) results primarily from a platelet adhesion defect, and not reduced enzyme activity or platelet activation, however, at temperatures below 33 degrees C, both reduced platelet function and enzyme activity likely contribute to the coagulopathy.
Abstract
Our results suggest that bleeding observed at mildly reduced temperatures (33 degrees - 37 degrees C) results primarily from a platelet adhesion defect, and not reduced enzyme activity or platelet activation. However, at temperatures below 33 degrees C, both reduced platelet function and enzyme activity likely contribute to the coagulopathy.
Keywords
Medicine
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