Epigenetic sources of behavioral differences in mice
Nature NeurosciencePublished 31 March 2003
Darlene Francis, Kathleen Szegda, Gregory Campbell, William Martin, Thomas R. Insel
Citations335
SJR quartileQ1
SJR score11.20
SNIP4.70
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TL;DR
It is reported that strain-related behavioral differences may result from environmental factors during development rather than genetic differences between the offspring.
Abstract
Inbred mouse strains are classically used to search for the genes associated with behavioral traits, including emotionality. To distinguish genetic and environmental contributions to the expression of adult behavior in mice, we investigated the effects of prenatal (embryo transfer) and postnatal (cross-fostering) environments in two strains of inbred mice with profound and reliable differences in behavior1. Here we report that strain-related behavioral differences may result from environmental factors during development rather than genetic differences between the offspring.
Keywords
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