Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus
Current BiologyPublished 1 April 2002Open access
Ruth A. Akhtar, Akhilesh B. Reddy, Elizabeth S. Maywood, Jonathan D. Clayton, Verdun M. King, Andrew G. Smith
Citations777
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
Temporally complex, circadian programming of the transcriptome in a peripheral organ is imposed across a wide range of core cellular functions and is dependent on an interaction between intrinsic, tissue-specific factors and extrinsic regulation by the SCN central pacemaker.
Abstract
Temporally complex, circadian programming of the transcriptome in a peripheral organ is imposed across a wide range of core cellular functions and is dependent on an interaction between intrinsic, tissue-specific factors and extrinsic regulation by the SCN central pacemaker.
Keywords
MedicineNeuroscience
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A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
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It used to be that research in chronobiology moved biochemical functions [transcriptional activators], the along at a gentlemanly pace, but by mid 1997 the word in determining what the authors perceive as time was PASWCCLK.
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710 Citations2001Shantha M. W. Rajaratnam, Joséphine Arendt
Although the increase in shiftwork has led to greater flexibility in work schedules, the ability to provide goods and services throughout the day and night, and possibly greater employment opportunities, the negative effects of shiftwork and chronic sleep loss on health and productivity are now being appreciated.
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As a small number of direct target genes are identified, the data suggest that most of the circadian gene network is indirectly regulated by clk, and that Drosophila has no clk-independent circadian systems.
Nature reviews. NeuroscienceHypothalamic integration of central and peripheral clocks
573 Citations2001Ruud M. Buijs, Andries Kalsbeek
The history of the study of circadian rhythms is reviewed and recent observations indicating that the same mechanisms that govern the central clock might be at work in the cells of peripheral organs are highlighted.
ScienceThe Structural Era of Endocytosis
556 Citations1999Mark Marsh, Harvey T. McMahon
Together, these data provide an initial three-dimensional framework for understanding the clathrin endocytic machinery and provide an initial three-dimensional framework for understanding the clathrin-mediated endocytic machinery.
Applied ErgonomicsThe impact of shift and night work on health
545 Citations1996Giovanni Costa
Shift work, in particular night work, can have a negative impact on health and well-being of workers as it can cause disturbances of the normal circadian rhythms of the psychophysiological functions.
Journal of Biological RhythmsThe Suprachiasmatic Nucleus: A 25-Year Retrospective
508 Citations1998David R. Weaver
The important steps forward in the understanding of the suprachiasmatic circadian clock are traced by recounting the information presented at the SCN Silver Anniversary Celebration.
NatureLight acts directly on organs and cells in culture to set the vertebrate circadian clock
476 Citations2000David Whitmore, Nicholas S. Foulkes +1 more
It is shown that the peripheral organ clocks of zebra fish are set by light–dark cycles in culture and that a zebrafish-derived cell line contains a circadian oscillator, which is also directly light entrained.
Mutation Research/Reviews in Mutation ResearchMammalian class theta GST and differential susceptibility to carcinogens: a review
475 Citations2000Stefano Landi
The comparison of the aminoacidic homologies among mammals suggests that a duplication of an ancient GST theta occurred before the speciation of mammals and resulted in the subunits GSTT1 and GSTT2, which are suspected to confer decreased or increased risk of cancer in relation to the source of exposure.
The Plant CellMicroarray Analysis of Diurnal and Circadian-Regulated Genes in Arabidopsis
456 Citations2001Robert J. Schaffer, Jeff Landgraf +4 more
By clustering microarray data from 47 additional nonrelated experiments, these groups contained the already characterized clock-associated genes LHY, CCA1, and GI, suggesting that other key circadian clock genes might be found within these clusters.
NeuronCircadian Regulation of Gene Expression Systems in the Drosophila Head
446 Citations2001Adam Claridge‐Chang, Herman Wijnen +4 more
The complement of circadian transcripts in adult Drosophila heads was determined and a subset of 158 genes showed particularly robust cycling and many oscillatory phases, associated with genes involved in diverse biological processes, including learning and memory/synapse function.
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425 Citations2000Jürgen A. Ripperger, Lauren P. Shearman +2 more
Evidence is presented that circadian Dbp transcription requires the basic helix-loop-helix-PAS protein CLOCK, an essential component of the negative-feedback circuitry generating circadian oscillations in mammals and fruit flies.
Genes & DevelopmentCircadian orchestration of gene expression in cyanobacteria.
366 Citations1995Yi Liu, N. F. Tsinoremas +5 more
The results show that screening organisms in which promoterless luciferase genes have been inserted randomly throughout the genome by homologous recombination provides an extremely sensitive method to explore differential gene expression.
Current BiologyCircadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells
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Journal of Biological ChemistryMultitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain
305 Citations1998Katsuhiko Sakamoto, Takahiro Nagase +9 more
It is suggested that the multitissue circadian expression of rPer2 mRNA was governed by the mammalian brain clock SCN and also suggest that the r per2 gene was involved in the circadian rhythm of locomotor behavior in mammals.
The Annual Review of Pharmacology and ToxicologyInterindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes
284 Citations2001Jiunn H. Lin, Anthony Y.H. Lu
A review examines the sources that are responsible for the large interindividual variability in response to enzyme inhibition and induction of cytochrome P450 enzymes.
Biochemical and Biophysical Research CommunicationsAntiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats
282 Citations1998Katsutaka Oishi, Katsuhiko Sakamoto +3 more
The amplitudes of BMAL1 and rPer2 mRNA expression levels were correlated between the different tissues, suggesting that the circadian expression of BMal1 mRNA plays an important role in generating the circadianexpression of per homologue genes in mammals.
TrafficDisabled‐2 Colocalizes with the LDLR in Clathrin‐Coated Pits and Interacts with AP‐2
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It is shown that the Dab2 phosphotyrosine‐binding domain binds peptides containing the sequence FXNPXY, which is found in the intracellular domains of LDLR family members and is important for receptor internalization.
Proceedings of the National Academy of SciencesRapid down-regulation of mammalian <i>Period</i> genes during behavioral resetting of the circadian clock
254 Citations1999Elizabeth S. Maywood, N. Mrosovsky +2 more
Circadian oscillations of Per1 and Per2 in the SCN of the Syrian hamster are described, showing that PER1 protein and mRNA cycles again behave in a manner consistent with a negative-feedback oscillator, and it is demonstrated that nonphotic resetting has the opposite effect to light: acutely down-regulating these genes.
ScienceA Circadian Output in <i>Drosophila</i> Mediated by <i>Neurofibromatosis-1</i> and Ras/MAPK
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Immunohistochemical staining revealed a circadian oscillation of phospho-MAPK in the vicinity of nerve terminals containing pigment-dispersing factor (PDF), a secreted output from clock cells, suggesting a coupling of PDF to Ras/MAPK signaling.
NatureChanges in abundance or structure of the per gene product can alter periodicity of the Drosophila clock
229 Citations1987Mary K. Baylies, Thaddeus A. Bargiello +2 more
It is suggested that perl and pers mutants produce hypoactive and hyperactive per proteins, respectively, which are inversely correlated with period length, so that flies with lowest levels of the per product have slow-running biological clocks.
Free Radical Biology and MedicineCYP2E1-dependent toxicity and oxidative stress in HepG2 cells,
210 Citations2001Arthur I. Cederbaum
Surprisingly, CYP2E1-expressing cells had elevated GSH levels, due to transcriptional activation of gamma glutamyl cysteine synthetase, and levels of catalase, alpha-, and microsomal glutathione transferase were increased, suggesting that upregulation of these antioxidant genes may reflect an adaptive mechanism to remove CYP1-derived oxidants.
Journal of Biological RhythmsCircadian Photoreception in <i>Drosophila</i> : Functions of Cryptochrome in Peripheral and Central Clocks
160 Citations2001Maria G. Ivanchenko, Ralf Stanewsky +1 more
It is concluded that cryptochrome is involved in TIM-mediated entrainment of both central LN and peripheral MT clocks, and that neural and epithelial cells share the core clock mechanism, some clock components and light-entrainment pathways appear to have tissue-specific roles.
Current BiologySynaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis
136 Citations2000Nicole Malecz, Peter C. McCabe +4 more
Results suggest that synaptojanin 2 may mediate the inhibitory effect of Rac1 on endocytosis and could contribute to Rac1-mediated control of cell growth.
Journal of Biological ChemistryCircadian Regulation of Diverse Gene Products Revealed by mRNA Expression Profiling of Synchronized Fibroblasts
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OncogeneGene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance
123 Citations2001Nicola J. Turton, D J Judah +6 more
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Nucleic Acids ResearchAnalysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs
120 Citations2001Benoı̂t Kornmann
Nearly 300 cDNA fragments complementary to mRNAs with circadian accumulation profiles and sequenced 51 of them suggest that a primary purpose of circadian transcription in the liver is the anticipation of food processing and detoxification.
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Most aspects of physiology and behaviour are governed by a central clock mechanism in the hypothalamus, which acts on neural and endocrine pathways to regulate individual circadian rhythms so that internal state varies predictably over 24 hours.
Animal BehaviourSpectral analysis of Drosophila courtship song rhythms
84 Citations1989Charalambos P. Kyriacou, Jeffrey C. Hall
A large body of data was reanalysed with appropriate time series analyses and results confirm the original conclusions based on regression about song cycles in Drosophila courtship songs.
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62 Citations1995Russell N. Van Gelder, Helen Bae +2 more
The goals of this work were to evaluate the extent and character of circadian control of gene expression in Drosophila, and to identify genes dependent on per for circadian expression, which involves many uncharacterized genes.
International Journal of CancerLinkage and association of CYP17 gene in hereditary and sporadic prostate cancer
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Comparative Biochemistry and Physiology Part B Comparative BiochemistryDiurnal rhythms in liver carbohydrate metabolism. Comparative aspects and critical review
18 Citations1987Yury G. Kaminsky, Еlena Kosenko
Literature data on the diurnal rhythms of blood glucose, liver glycogen levels and key hepatic enzyme activities of glycolysis, gluconeogenesis, glycogen metabolism and lipogenesis in animals are reviewed.
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6 Citations1987Feuers Rj, Casciano Da +2 more
Results indicate that the circadian rhythm for PK activity is composed of at least two components, including covalent modification and catalytic activity, which is high during the dark and early light phases but decreases at the end of the light phase.
