Cocaine: History, Use, Abuse
Journal of the Royal Society of MedicinePublished 1 August 1999Open access
Steven B. Karch
Citations60
SJR quartileQ1
SJR score1.71
SNIP1.79
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TL;DR
The net effect of technical advances in the cocaine trade has been to increase the amount of cocaine that users of this drug can get into their bodies.
Keywords
PsychologyNeurosciencePharmacology, Toxicology and Pharmaceutics
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201 Citations1991Richard W. Foltin, Marian W. Fischman
The effects of specific cocaine plasma levels on cardiovascular activity and some subjective reports were diminished across the session, demonstrating the development of acute tolerance to cocaine.
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The "body packer syndrome" should be considered in any international traveler who dies suddenly, has seizures, or presents with any signs consistent with cocaine toxicity, as it is found in victims found dead at home or in hotel rooms with little or no drug paraphernalia.
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This survey continues a second series of compilations of data regarding changes in body temperature induced by drugs and related agents, published from 1980 to 1984 but data from many earlier papers are also tabulated.
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The degree of myocardial hypertrophy documented in this study was highly significant, but because the increase is modest (around 10%), it is likely to go unrecognized at autopsy.
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The adrenergic and local anesthetic properties of cocaine could act synergistically to elicit toxic actions on the heart in the genesis of malignant arrhythmias.
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73 Citations1992Mark M. Knuepfer, C A Branch
The data suggest that cocaine produces an initial, brief centrally mediated sympathoexcitation, but the sustained, modest pressor response is dependent upon peripheral actions that are diminished by baroreflex activation.
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68 Citations1979Bo Holmstedt, Jan‐Erik Lindgren +2 more
There is no reason to believe that the stimulating effect achieved by the use of either coca leaves or powder is not due to cocaine.
The Medical Journal of AustraliaCocaine abuse with hyperthermia, seizures and fatal complications
40 Citations1988Bruce Campbell
The case of a previously‐healthy woman who developed marked hyperthermia after the intravenous self‐administration of cocaine is described, followed by the development of rhabdomyolysis, disseminated intravascular coagulation, acute renal failure, impaired cerebral function and hepatic dysfunction.
Archives of Internal MedicineInfluence of Cocaine, Ethanol, or Their Combination on Epicardial Coronary Arterial Dimensions in Humans
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The combination of intranasal cocaine and intravenous ethanol causes an increase in the determinants of myocardial oxygen demand, however, it also causes a concomitant increase in epicardial coronary arterial diameter.
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34 Citations1988Jan S. Rosenbaum, Margaret E. Billingham +4 more
A catecholamine-induced cardiomyopathy in hearts from pheochromocytoma-bearing rats is demonstrated, whereas maximal contraction of heart muscle, induced by either isoproterenol or calcium chloride, remains intact.
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33 Citations1998Francis J. White
The responses of the knockout mice to cocaine now indicate that the neurotransmitter serotonin was involved in the processes that underlie vulnerability to cocaine addiction, and that it is — through this receptor at least.
British Journal of AddictionEpidemic Cocaine Abuse: America's present, Britain's future?*
33 Citations1988Herbert D. Kleber
The historical setting in which cocaine first became a problem in America at the turn of the century and its recent re-emergence is reviewed and possible interventions that might lessen the problem if adopted are listed.
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30 Citations1997Sophie Besse, Patrick Assayag +6 more
In conclusion, cocaine activates markers of both hemodynamic overload and fibrosis, which may result from direct and/ or indirect effects of the drug such as myocardial ischemia, mechanical overload and/or hypothyroidism.
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During 1994, researchers from a number of different laboratories reported observations that, taken together, may explain what cocaine does to the heart and go a long way toward explaining what causes cardiac arrest in cocaine users.
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PubMed[E. Merck and cocaine. On Sigmund Freud's cocaine studies and their relation to the Darmstadt industry].
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Documents from the archives of the pharmaceutical company, E. Merck, Darmstadt, shed light on research, production, and marketing of cocaine and other coca alkaloids and how it is compared with that of other companies in Germany and abroad.