The Genome Sequence and Evolution of Baculoviruses
Annual Review of EntomologyPublished 2 December 2002
Elisabeth A. Herniou, Julie A. Olszewski, J. S. Cory, David R. O’Reilly
Citations467
SJR quartileQ1
SJR score4.66
SNIP6.73
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TL;DR
Comparative analysis of the complete genome sequences of 13 baculoviruses revealed a core set of 30 genes, 20 of which have known functions, which provided evidence for two putative DNA repair systems and for viral proteins specific for infection of lymantrid hosts.
Abstract
Comparative analysis of the complete genome sequences of 13 baculoviruses revealed a core set of 30 genes, 20 of which have known functions. Phylogenetic analyses of these 30 genes yielded a tree with 4 major groups: the genus Granulovirus (GVs), the group I and II lepidopteran nucleopolyhedroviruses (NPVs), and the dipteran NPV, CuniNPV. These major divisions within the family Baculoviridae were also supported by phylogenies based on gene content and gene order. Gene content mapping has revealed the patterns of gene acquisitions and losses that have taken place during baculovirus evolution, and it has highlighted the fluid nature of baculovirus genomes. The identification of shared protein phylogenetic profiles provided evidence for two putative DNA repair systems and for viral proteins specific for infection of lymantrid hosts. Examination of gene order conservation revealed a core gene cluster of four genes, helicase, lef-5, ac96, and 38K(ac98), whose relative positions are conserved in all baculovirus genomes.
Keywords
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Phylogenetic profiles were constructed for each herpesvirus from the homologous protein families and used to determine conserved functions and genomewide phylogenetic trees and allowed greater insight into the phylogeny of ungulate and murine gammaherpesviruses.
Journal of General VirologyIdentification and characterization of the Cydia pomonella granulovirus cathepsin and chitinase genes.
74 Citations1998Woojin Kang, Michael Tristem +3 more
Phylogenetic trees were constructed for both chitinase and cathepsin sequences from baculoviruses and other species, suggesting both genes were present in an ancestral virus prior to the separation of the two genera.
Journal of VirologyIdentification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation
74 Citations1997Julie A. Olszewski, Lois K. Miller
The defect in a temperature-sensitive mutant of Autographa californica nuclear polyhedrosis virus, tsN1054, was mapped and characterized, and VP1054 is a virus structural protein required for nucleocapsid assembly.
VirologyNucleotide sequence, transcriptional mapping, and temporal expression of the gene encoding p39, a major structural protein of the multicapsid nuclear polyhedrosis virus of Orgyia pseudotsugata
72 Citations1989Gary W. Blissard, Rebecca L. Quant-Russell +2 more
The gene encoding the 39-kDa major structural protein of Orgyia pseudotsugata nuclear polyhedrosis virus (OpMNPV) was sequenced and transcriptionally mapped, and its expression was examined at various times postinfection.
Journal of VirologyIdentification of three late expression factor genes within the 33.8- to 43.4-map-unit region of Autographa californica nuclear polyhedrosis virus
72 Citations1994Albert Lu, Lois K. Miller
Three genes within the 33.8- to 43.4-map-unit region of the A. californica nuclear polyhedrosis virus genome which contribute to expression from promoters of the vp39 major capsid protein and polyhedrin genes are identified.
VirologyA Role for Baculovirus GP41 in Budded Virus Production
71 Citations1997Julie A. Olszewski, Lois K. Miller
Electron microscopy revealed that nucleocapsids were produced but retained in the nucleus of tsB1074-infected cells at 33 degrees, indicating an additional role for GP41 in budded virus formation, and marker rescue mapping and DNA sequencing correlated a single nucleotide substitution within the baculovirus gp41 gene with the temperature-sensitive phenotype of ts B1074.
Proceedings of the National Academy of SciencesThe structural protein ODV-EC27 of <i>Autographa californica</i> nucleopolyhedrovirus is a multifunctional viral cyclin
70 Citations1998Michail Belyavskyi, Sharon C. Braunagel +1 more
It is shown that Autographa californica nucleopolyhedrovirus (AcMNPV) encodes for a multifunctional cyclin that may partially explain the molecular basis of these important characteristics of AcM NPV (baculovirus) infection.
Journal of VirologyFurin Is Involved in Baculovirus Envelope Fusion Protein Activation
68 Citations2002Marcel Westenberg, Huálín Wáng +4 more
The envelope fusion protein from group II nucleopolyhedroviruses of baculoviruses has properties similar to those of proteins from a number of vertebrate viruses.
Virus ResearchRecombination as a possible major cause of genetic heterogeneity in Anticarsia gemmatalis nuclear polyhedrosis virus wild populations
67 Citations1992G. Croizier, Helena Camarão Telles Ribeiro
The predominant reassociation of neutral DNA genomic markers following double infection of Sf9 cells by pairs of parental AgMNPVs indicates the potency of intrapopulation genetic recombination in a wild isolate to redistribute DNA sequences in the genetic pool of this virus.
Journal of VirologyCharacterization of the interaction between the baculovirus replication factors LEF-1 and LEF-2
67 Citations1997Jay T. Evans, Douglas J. Leisy +1 more
The Autographa californica multinucleocapsid nuclear polyhedrosis virus has six genes required and three genes stimulatory for transient DNA replication, and the products of two of these genes, LEF-1 and LEf-2, interact in both two-hybrid assays using Saccharomyces cerevisiae and glutathione S-transferase fusion affinity assays.
Virologyp39, a major baculovirus structural protein: Immunocytochemical characterization and genetic location
65 Citations1988Margot Pearson, Rebecca L.Q. Russell +2 more
Using the lambda gt11 insert DNAs and the monoclonal antibodies, the p39 genes and proteins of OpMNPV and Autographa californica NPV were shown to be closely related in size, DNA sequence, and antigenicity.
Journal of VirologyNucleotide sequence and transcriptional analysis of a gene encoding gp41, a structural glycoprotein of the baculovirus Autographa californica nuclear polyhedrosis virus
65 Citations1992M F Whitford, P. Faulkner
A region of the Autographa californica nuclear polyhedrosis virus (AcMNPV) genome encoding the major polyhedron-derived virus structural glycoprotein gp41 is identified and sequenced.
Journal of VirologyGuanylyltransferase Activity of the LEF-4 Subunit of Baculovirus RNA Polymerase
62 Citations1998Linda A. Guarino, Jian‐Ping Jin +1 more
To demonstrate that LEF-4 was the guanylyltransferase, the single subunit was overexpressed in baculovirus-infected cells and was able to covalently bind GMP, although less efficiently than viral RNA polymerase.
VirologyCharacterization of a Baculovirus-Encoded Protein That Is Associated with Infected-Cell Membranes and Budded Virions
57 Citations2001Margot Pearson, Rebecca L.Q. Russell +1 more
The characterization of a LD130 homolog (OP21) from OpMNPV, which also contains gp64, is described, andConfocal immunofluorescence microscopy showed that OP21 and GP64 have a similar pattern of distribution on the membrane of cells infected with OpM NPV, and Immunoelectron microscopy of budded virions showed similar patterns of localization for both OP21.
Baculovirus Structure
55 Citations1997C. Joel Funk, Sharon C. Braunagel +1 more
VirologyCharacterization of P91, a Protein Associated with Virions of anOrgyia pseudotsugataBaculovirus
52 Citations1997Rebecca L.Q. Russell, George F Rohrmann
Fractionation studies employing NP-40 and Western blot analysis indicated that P91 was associated with the capsid structure and localization of P91 by confocal immunofluorescence microscopy showed that the protein was concentrated near the nuclear membrane and at late times p.i. was most concentrated near polyhedra.
Journal of General VirologyCharacterization of the ecdysteroid UDP-glucosyltransferase gene from Mamestra brassicae nucleopolyhedrovirus
50 Citations1996E. E. Clarke, Michael Tristem +2 more
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