Rules of Evidence and Clinical Recommendations on the Use of Antithrombotic Agents

The nonexperimental evidence that forms the recalled experiences of seasoned clinicians will tend to overestimate efficacy for the following reasons:.

Abstract

What rules of evidence ought to apply when expert committees meet to generate recommendations for the clinical management of patients? Should only the thoroughly validated results of randomized clinical trials be admissible to avoid or minimize the application of useless or harmful therapy? Or, to maximize the potential benefits to patients (including those possible from unproved remedies), ought a synthesis of the experiences of seasoned clinicians form the basis for such recommendations?