Quantitative Studies of Mitoses and DNA‐Synthesizing Cells in Bone Marrow and Blood of Guinea‐Pigs Recovering from Sublethal Whole‐Body Gamma Irradiation*
British Journal of HaematologyPublished 1 July 1963
P.F. Harris, G. Haigh, J. H. Kugler
Citations29
SJR quartileQ1
SJR score1.65
SNIP1.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
Keywords
Biochemistry, Genetics and Molecular Biology
British Journal of HaematologyCytochemical Demonstration and Measurement of Leucocyte Alkaline Phosphatase Activity in Normal and Pathological States by a Modified Azo‐Dye Coupling Technique
189 Citations1958F. G. J. Hayhoe, Daniela Quaglino
The Gomori technique, Wachstein (1946) and Plum (1950) found the alkaline phosphatase activity of blood cells to be confined to the more mature granulocytes, in sharp contrast to inflammatory leucocytoses, leukaenioid reactions and myelofibrosis.
Acta HaematologicaProliferative Potentials of Bone Marrow and Blood Cells Studied by in vitro Uptake of H <sup>3</sup> -Thymidine
154 Citations2009V.P. Bond, Theodor M. Fliedner +4 more
Most striking was the finding of small numbers of labeled large mononuclear cells of different morphological types in the peripheral blood of normal human beings, and an increase in the number of morphologically identical cells in the blood of patients with infection and infectious mononucleosis.
BloodEFFECTS OF X-RAY ON LYMPHOID AND HEMOPOIETIC TISSUES OF ALBINO MICE
109 Citations1948G. Brecher, K. M. Endicott +2 more
Differences in the relative amount of damage to lymphoid and myeloid tissues and in their rates of regeneration were not of sufficient magnitude to indicate a truly selective damage to the lymphoid tissues under the conditions of the authors' expermiments.
Journal of the American Medical AssociationLymphocytes and Mast Cells
78 Citations1960I. Davidsohn
This monograph is an attempt to gather between the covers of a small book what has been written about lymphocytes, mast cells, and certain other cells that supply nutritive materials and regulate protein metabolism.
Experimental Cell ResearchThe culture of lymph nodes in vitro
67 Citations1952O. A. Trowell
It was shown that the lymphocytes would only survive under conditions of good oxygen supply, which meant in practice that the greater part of the surface of the culture had to be in contact with pure oxygen gas.
BMJQuantitative Examination of Bone Marrow in Guinea-pigs After Gamma Irradiation
47 Citations1956P.F. Harris
British Journal of HaematologyThe Influence of Environment on Iron Incorporation and Mitotic Division in a Suspension of Normal Bone Marrow*
40 Citations1960Allan J. Erslev, James Hughes
It seems most likely that the formation of pronormoblasts is controlled by the dcmand for red cells in the body, a demand which probably is relayed to the stem cells of the bone marrow by means of an erythropoietic demand.
BloodMorphologic and Autoradiographic Observations of H3-Thymidine-Labeled Thoracic Duct Lymphocytes Cultured in Vivo
37 Citations1960J. C. Schooley, Irwin R. Berman
It was concluded that some unidentified cells, presumably the largest cells which are normally present in thoracic duct lymph, can be transformed into these other cell types when appropriately stimulated.
Acta HaematologicaThe Mitotic Index of Human Bone Marrow in Healthy Individuals and Irradiated Human Beings
27 Citations2009Theodor M. Fliedner, E. P. Cronkite +3 more
The mitotic index of the bone marrow of 7 healthy individuals was determined in Feulgen stained squash preparations to be 0.9% and it is possible to estimate the average turnover time of the red cell series and that of the white cell series to be in the order of 25 to 75 hours.
NatureHazard of Tritium as a Deoxyribonucleic Acid Label in Man
27 Citations1960R. Oliver, L. G. Lajtha
An increased relative biological effectiveness is to be expected for these low-energy beta-particles compared with gamma radiation, and from observations of radiation effects on cell growth, Pinson and Langham3 have suggested that a value of 1.7 should be used.
BloodThe Lymphocyte-Like Cell in the Marrow of Rats
25 Citations1961Charles Harris
The lymphocyte-like cell of rat marrow is capable of performing as a multipotential cell, and resembles a small lymphocyte, and reacts to the effects of cortisone and thio-TEPA, as do small lymphocytes in other organs, thus should be called aSmall lymphocyte.
Archives of Internal MedicineLymphocyte Production and Turnover
20 Citations1959Seymour Perry
Most authorities now accept 9 to 13 days as the life span of the granulocyte1,2 and perhaps 200 days for the lymphocyte, but one must reconcile this with a large background of sound experimental work, which indicates that circulating mass of lymphocytes turns over very rapidly, implying a short life span.
Novartis Foundation symposiumModels for Lymphocyte and Plasmocyte Formation
12 Citations2008C. P. Leblond, G Sainte-Marie
NatureCells which Synthesize Deoxyribonucleic Acid in Guinea Pig Bone Marrow During Recovery from Whole-Body γ-Irradiation
4 Citations1959P.F. Harris, J. H. Kugler
Findings in these experiments suggested the possibility that the intermediate cells, intermediate in appearance and size between small lymphocytes and blast cells, might be considered as early free stem-cells.