An Expanded Evaluation of the Relationship of Four Alleles to the Level of Response to Alcohol and the Alcoholism Risk
Alcoholism Clinical and Experimental ResearchPublished 1 January 2005
Xian‐Zhang Hu, Gábor Oroszi, Jeffrey Chun, Tom L. Smith, David Goldman, Marc A. Schuckit
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TL;DR
Support is found for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence.
Abstract
This report strengthens the support for a relationship between the HTTLPR L and GABAAalpha6 Ser385 alleles to low alcohol LR and to alcoholism in a prospectively studied cohort evaluated for LR in young adulthood and before the onset of alcohol dependence.
Keywords
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27 Citations1995Ulrike M. Koechling, Zalman Amit +1 more
The lack of effect of acute alcohol intake on the possible induction of CA further supported the notion that CA may be a viable marker of alcohol intake, rather than the converse.
CellY Do We Drink?
19 Citations1998Laurence H. Tecott, Ulrike Heberlein
The observation of increased ethanol preference in NPY-KO mice raises the possibility that the regulation of reward pathways may be included among the many actions of this neuropeptide.
Human GeneticsAssociation of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men
18 Citations1999Fang Sun, Ikiko Tsuritani +3 more
Journal of Studies on AlcoholBrain alcohol detectability in human subjects with and without a paternal history of alcoholism.
16 Citations2004Tak‐Ming Chiu, Jack H. Mendelson +5 more
Differences in the Subjective High Assessment Scale ratings between the two groups, however, indicate the importance of a genetic influence on the subjective response to alcohol.
Journal of Studies on AlcoholPatterns of drug-related disorders in a prospective study of men chosen for their family history of alcoholism.
11 Citations2004Marc A. Schuckit, George P. Danko +1 more
Disorders related to illicit substances were common in this well-educated, highly functional population of middle-class men, and diagnostic overlap between AUDs and illicit substance-related disorders might reflect concomitant family histories of alcoholism and substance- related conditions and, perhaps, family history of manic depressive disease.
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