The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury
InjuryPublished 27 December 2012Open access
Andrés M. Rubiano, Á. Sánchez, Glyn Estebanez, Andrew B. Peitzman, Jason L. Sperry, Juan Carlos Puyana
Citations37
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TL;DR
The presence of spontaneous hypothermia at hospital admission is associated with a significant increase in the risk of mortality in patients with severe TBI.
Abstract
The presence of spontaneous hypothermia at hospital admission is associated with a significant increase in the risk of mortality in patients with severe TBI. The benefit of maintaining normothermia in severe TBI patients, the impact of prolonged re-warming in patients with established hypothermia and the introduction of prophylactic measures to complications of hypothermia are key points that require further investigation.
Keywords
Medicine
CHEST JournalCritical Care Medicine
1,999 Citations1971Peter Šafář, Åke Grenvik
An attempt has been made to direct the evolution of critical care medicine based on the author's personal experiences with the development of emergency care and intensive care programs during the past decade, and on review of the available literature.
New England Journal of MedicineLack of Effect of Induction of Hypothermia after Acute Brain Injury
1,382 Citations2001Guy L. Clifton, Emmy R. Miller +10 more
Treatment with hypothermia, with the body temperature reaching 33 degrees C within eight hours after injury, is not effective in improving outcomes in patients with severe brain injury.
JAMAPerioperative Maintenance of Normothermia Reduces the Incidence of Morbid Cardiac Events
1,253 Citations1997Steven M. Frank
BMJPredicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
1,213 Citations2008MRC CRASH Trial Collaborators
Simple prognostic models can be used to obtain valid predictions of relevant outcomes in patients with traumatic brain injury and external validation for unfavourable outcome at six months in high income countries showed that basic and CT models had good discrimination but poorer calibration.
The LancetMild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty
942 Citations1996Harald Schmied, Audra J. Reiter +3 more
The maintenance of intraoperative normothermia reduces blood loss and allogeneic blood requirements in patients undergoing total hip arthroplasty and increases blood loss in the hypothermic patients.
The Journal of Trauma: Injury, Infection, and Critical CareHypothermia in Trauma Victims
708 Citations1987Gregory J. Jurkovich, WILLIAM B. GREISER +2 more
Mortality and the incidence of hypothermia increased with higher ISS, massive fluid resuscitation, and the presence of shock, and within each subgroup the mortality of Hypothermic patients was significantly higher than those who remained warm.
New England Journal of MedicineHypothermia Therapy after Traumatic Brain Injury in Children
690 Citations2008James S. Hutchison, Roxanne Ward +15 more
In children with severe traumatic brain injury, hypothermia therapy that is initiated within 8 hours after injury and continued for 24 hours does not improve the neurologic outcome and may increase mortality.
The LancetInduced hypothermia and fever control for prevention and treatment of neurological injuries
600 Citations2008Kees H. Polderman
Journal of NeurotraumaA Phase II Study of Moderate Hypothermia in Severe Brain Injury
541 Citations1993Guy L. Clifton, Steven J. Allen +7 more
The Journal of Trauma: Injury, Infection, and Critical CareA Systematic Evaluation of the Effect of Temperature on Coagulation Enzyme Activity and Platelet Function
519 Citations2004Alisa S. Wolberg, Zhi Hong Meng +2 more
The results suggest that bleeding observed at mildly reduced temperatures (33 degrees - 37 degrees C) results primarily from a platelet adhesion defect, and not reduced enzyme activity or platelet activation, however, at temperatures below 33 degrees C, both reduced platelet function and enzyme activity likely contribute to the coagulopathy.
StrokeFeasibility and Safety of Moderate Hypothermia After Massive Hemispheric Infarction
432 Citations2001Stefan Schwab, Dimitrios Georgiadis +4 more
The most frequent complications of hypothermic therapy were thrombocytopenia, bradycardia, and pneumonia, and four patients died during hypothermia as a result of severe coagul...
Injury PreventionAn introduction to the Barell body region by nature of injury diagnosis matrix
385 Citations2002Vita Barell, Limor Aharonson‐Daniel +7 more
The Barell injury diagnosis matrix introduces new ideas such as the separation of traumatic brain injury (TBI), into three types, and has the potential to serve as a basic tool in epidemiological and clinical analyses of injury data.
NeurosurgeryPhase II Clinical Trial of Moderate Hypothermia after Severe Traumatic Brain Injury in Children
327 Citations2005P. David Adelson, John Ragheb +8 more
Moderate hypothermia after severe TBI in children was found to be safe relative to standard management and NORM in children of all ages and in children with delay of initiation of treatment up to 24 hours, and functional outcome tended to improve from the 3- to 6-month cognitive assessment in HYPO compared with NORM.
The Journal of Trauma: Injury, Infection, and Critical CareHarbingers of Poor Outcome the Day after Severe Brain Injury: Hypothermia, Hypoxia, and Hypoperfusion
315 Citations2003Élan Jeremitsky, Laurel Omert +3 more
The authors' early management of head-injured patients stresses avoidance and correction of SBIFs at all costs, Nonetheless, SBIF occur frequently in the first 24 hours after traumatic brain injury.
Critical Care MedicineAdmission hypothermia and outcome after major trauma
281 Citations2005Henry E. Wang, Clifton W. Callaway +2 more
Admission hypothermia is independently associated with increased adjusted odds of death after major trauma, and the increase in mortality is not completely attributable to physiologic presentation or injury pattern or severity.
Journal of neurosurgeryEffect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases
274 Citations2000Ji-Yao Jiang, Ming-Kun Yu +1 more
The data produced by this study demonstrate that long-term mild hypothermia therapy significantly improves outcomes in patients with severe TBI.
Survey of AnesthesiologyPerioperative Maintenance of Normothermia Reduces the Incidence of Morbid Cardiac Events
271 Citations1997Steven M. Frank, Lee A. Fleisher +6 more
Journal of NeurotraumaHypothermia Treatment for Traumatic Brain Injury: A Systematic Review and Meta-Analysis
250 Citations2008Kim Peterson, Susan Carson +1 more
An updated meta-analysis of the effects of hypothermia therapy on mortality, favorable neurologic outcome, and associated adverse effects in adults with traumatic brain injury (TBI) for use by BTF/AANS task force supports previous findings that hypothermic therapy constitutes a beneficial treatment of TBI in specific circumstances.
PubMedHypothermia and blood coagulation: dissociation between enzyme activity and clotting factor levels.
192 Citations1990Richard Reed, Arthur Bracey +3 more
Data indicate that the coagulopathy observed during hypothermia is, in part, independent of clotting factor levels, and appears proportional to the number of enzymatic steps involved.
PubMedThe role of hypothermia in the management of severe brain injury: a meta-analysis.
192 Citations2002Odette A. Harris, John M. Colford +2 more
This meta-analysis of randomized controlled trials suggests that hypothermia is not beneficial in the management of severe head injury, and additional studies are justified and urgently needed.
Journal of NeurotraumaThe Importance of Brain Temperature in Patients after Severe Head Injury: Relationship to Intracranial Pressure, Cerebral Perfusion Pressure, Cerebral Blood Flow, and Outcome
166 Citations2002Jens Soukup, Alois Zauner +5 more
Simultaneous monitoring of brain and rectal temperature provides important diagnostic and prognostic information to guide the treatment of patients after severe head injury and the wide differentials that can develop between the brain and core temperature, especially during rapid cooling, strongly supports the use of brain temperature measurement if therapeutic hypothermia is considered for head injury care.
The Journal of Trauma: Injury, Infection, and Critical CareIncidence and Timing of Hypothermia in Trauma Patients Undergoing Operations
163 Citations1991James S. Gregory, Louis Flancbaum +3 more
Hypothermia was associated with lower Trauma Scores, and those patients who were severely hypothermic received more intravenous fluids, however, the impact of fluid infusion was not independent from Trauma Score and did not fully explain the magnitude of the heat loss.
The Journal of UrologyPerioperative Maintenance of Normothermia Reduces the Incidence of Morbid Cardiac Events. A Randomized Clinical Trial
163 Citations1998Steven M. Frank, Lee A. Fleisher +5 more
In patients with cardiac risk factors who are undergoing noncardiac surgery, the perioperative maintenance of normothermia is associated with a reduced incidence of morbid cardiac events and ventricular tachycardia.
Journal of NeurotraumaHypothermia on Admission in Patients with Severe Brain Injury
138 Citations2002Guy L. Clifton, Emmy R. Miller +7 more
The treatment effect was found in all of the four centers, which randomized the majority (80%) of the patients, and it is unclear whether the improved outcome when hypothermia is maintained is a beneficial effect of very early Hypothermia induction or an adverse effect of permitting the patients to rewarm passively.
Surgical Clinics of North AmericaEnvironmental Cold-Induced Injury
131 Citations2007Gregory J. Jurkovich
The incidence of hypothermia is examined, its detrimental effect on trauma patients, and methods of rewarming the hypothermic patient are examined, and the controversial protective roleHypothermia might play in shock, organ transplantation, cardiac arrest, and brain injury is looked at.
Current Pharmaceutical DesignCooling the Injured Brain: How Does Moderate Hypothermia Influence the Pathophysiology of Traumatic Brain Injury
128 Citations2007Juan Sahuquillo, Anna Vilalta
By targeting many of the abnormal neurochemical cascades initiated after TBI, induced hypothermia may modulate neurotoxicity and, consequently, may play a unique role in opening up new therapeutic avenues for treating severe TBI and improving its devastating effects.
British Journal of AnaesthesiaCerebrovascular reactivity during hypothermia and rewarming
127 Citations2007Andrea Lavinio, Ivan Timofeev +9 more
After moderate hypothermia, rewarming exceeding the 37 degrees C threshold is associated with a significant increase in average PRx, indicating temperature-dependent hyperaemic derangement of cerebrovascular reactivity.
RePEc: Research Papers in EconomicsICDPIC: Stata module to provide methods for translating International Classification of Diseases (Ninth Revision) diagnosis codes into standard injury categories and/or scores
122 Citations2010David E. Clark, Turner Osler +1 more
The intention of the ICD Programs for Injury Categorization (ICDPIC) is to provide inexpensive methods for translating International Classification of Diseases (Ninth Revision) diagnosis codes into standard injury categories and/or scores.
NeurosurgeryThe Effect of Hypothermia on the Incidence of Delayed Traumatic Intracerebral Hemorrhage
111 Citations1994Daniel K. Resnick, Donald W. Marion +1 more
The short-term use of hypothermia does not appear to increase the risk for intracranial hemorrhagic complications in head injuries, and the possibility of ahypothermia-induced coagulopathy has not yet been excluded.
American Journal of Physiology-Heart and Circulatory PhysiologyNeuroprotection in hypothermia linked to redistribution of oxygen in brain
97 Citations2003Masaharu Sakoh, Albert Gjedde
The claim that cooling of the brain to 32 degrees C couples both energy metabolism and blood flow to a lower rate of work of the entire tissue is consistent with the claim that hypothermia improves the outcome of acute ischemic stroke, traumatic injury, and inflammation of brain tissue.
Journal of NeurotraumaPosthypothermic Rewarming Considerations following Traumatic Brain Injury
91 Citations2009John T. Povlishock, Enoch P. Wei
Evidence is presented that the rate of posthypothermic rewarming is an important variable for influencing the protective effects of hypothermic intervention following TBI, and multiple lines of clinical evidence suggest the benefits of posttraumatic hypothermia are optimized through the use of slow rewarming.
The American Journal of Emergency MedicineHypothermia-induced coagulopathy during hemorrhagic shock
77 Citations2001Kevin R. Krause, Greg A. Howells +5 more
Clinical Neurology and NeurosurgeryMild hypothermia therapy for patients with severe brain injury
73 Citations2002Roman Gál, Ivan Čundrle +2 more
The results showed that mild therapeutic hypothermia could be useful in improving the outcome and neurological recovery in patients with severe head injuries.
The Journal of Trauma: Injury, Infection, and Critical CareEffect of 35°C Hypothermia on Intracranial Pressure and Clinical Outcome in Patients With Severe Traumatic Brain Injury
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Cooling patients to 35 degrees C is safe and the ICP reduction effects of35 degrees C hypothermia are similar to those of 33 degrees Chypothermia, which is associated with fewer complications and improved outcomes.
The American SurgeonHypothermia-Induced Coagulopathy during Hemorrhagic Shock
63 Citations2000Kevin R. Krause, Greg A. Howells +5 more
It is concluded that when shock and hypothermia occur together, their deleterious effect on hemodynamic and coagulation parameters are additive and it is necessary to aggressively address both shock and Hypothermia when they occur simultaneously.
Journal of neurosurgeryDiscrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial
61 Citations2009Odette A. Harris, Carrie R. Muh +5 more
The cooling cap was not effective in establishing a statistically significant cranial-bladder temperature gradient or in reaching the target intracranial temperature in the majority of patients.
Journal of Leukocyte BiologyGender dimorphism following injury: making the connection from bench to bedside
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The Journal of Trauma: Injury, Infection, and Critical CareMild Hypothermia Reduces Expression of Heat Shock Protein 60 in Leukocytes from Severely Head-Injured Patients
44 Citations2003Naoyuki Hashiguchi, Tadahiko Shiozaki +9 more
Mild hypothermia reduces the expression of Heat shock protein (HSP) 60 in PMNLs from severely head-injured patients, suggesting that mild Hypothermia may suppress innate immunity.
The Journal of Trauma: Injury, Infection, and Critical CareThe Impact of Nontherapeutic Hypothermia on Outcomes After Severe Traumatic Brain Injury
33 Citations2011Agathoklis Konstantinidis, Kenji Inaba +6 more
For patients who have sustained isolated severe TBI, the presence of noninduced, nontherapeutic hypothermia on SICU admission is associated with a significant increase in mortality.
Current Opinion in AnaesthesiologyTherapeutic hypothermia and traumatic brain injury
13 Citations2010C S De Deyne